Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0527 | 0.2208 | 0.2086 |
Trichomonas vaginalis | STE family protein kinase | 0.0937 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0419 | 0.0154 | 0.0154 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0937 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0419 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0527 | 0.2208 | 0.2242 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0937 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0937 | 1 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0419 | 0.0154 | 0.0154 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0937 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0797 | 0.7336 | 0.7336 |
Schistosoma mansoni | protein kinase | 0.0937 | 1 | 1 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0527 | 0.2208 | 0.2208 |
Entamoeba histolytica | protein kinase, putative | 0.0419 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0929 | 0.9846 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0527 | 0.2208 | 0.5 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0527 | 0.2208 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.0937 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0937 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0937 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0527 | 0.2208 | 0.2208 |
Trichomonas vaginalis | STE family protein kinase | 0.0937 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0419 | 0.0154 | 0.0154 |
Entamoeba histolytica | protein kinase, putative | 0.0937 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0527 | 0.2208 | 0.2242 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0527 | 0.2208 | 0.2208 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0519 | 0.2054 | 0.2054 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0937 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0797 | 0.7336 | 0.745 |
Entamoeba histolytica | p21-activated kinase | 0.0937 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0937 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0929 | 0.9846 | 0.9844 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0937 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 63 % | Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 25 uM measured on day 3 by Alamar Blue assay relative to 100 pM GLP2 | ChEMBL. | 22944117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.