Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | peter pan protein, putative | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | peter pan protein, putative | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0068 | 1 | 0.5 |
Onchocerca volvulus | Peter pan protein homolog | 0.0068 | 1 | 0.5 |
Echinococcus multilocularis | peter pan | 0.0068 | 1 | 1 |
Echinococcus granulosus | peter pan | 0.0068 | 1 | 1 |
Giardia lamblia | Peter pan protein | 0.0068 | 1 | 0.5 |
Trichomonas vaginalis | ssf, putative | 0.0068 | 1 | 0.5 |
Toxoplasma gondii | brix domain-containing protein | 0.0068 | 1 | 0.5 |
Trypanosoma brucei | brix domain containing protein, putative | 0.0068 | 1 | 0.5 |
Loa Loa (eye worm) | brix domain-containing protein | 0.0068 | 1 | 0.5 |
Plasmodium falciparum | BRIX domain, putative | 0.0068 | 1 | 0.5 |
Entamoeba histolytica | brix domain containing protein | 0.0068 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | peter pan protein, putative | 0.0068 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 88 uM | Inhibition of human thrombin using fluorogenic Cbz-Gly-Gly-Arg-NH-Mec as substrate measured over 400 secs by spectrophotometry | ChEMBL. | 23026080 |
Ki (binding) | = 208 uM | Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrophotometry | ChEMBL. | 23026080 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.