Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0168 | 0.2397 | 0.381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Echinococcus multilocularis | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0103 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.9356 | 0.9356 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0234 | 0.4539 | 0.7214 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.2388 | 0.3795 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Onchocerca volvulus | 0.0333 | 0.7801 | 0.5 | |
Brugia malayi | protein kinase C II. | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0287 | 0.6292 | 0.6292 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.2388 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0168 | 0.2397 | 0.381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 nM | Inhibition of PKCdelta by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 0.1 nM | Inhibition of PKCtheta by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 0.2 nM | Inhibition of PKCbeta-1 by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 0.4 nM | Inhibition of PKCalpha by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 0.7 nM | Inhibition of PKCepsilon by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 1.7 nM | Inhibition of PKCeta by scintillation proximity assay | ChEMBL. | 21797275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.