Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0467 | 0.3746 | 0.3621 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0197 | 0.0526 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1011 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0466 | 0.3731 | 0.3605 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0466 | 0.3731 | 0.9957 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0141 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0197 | 0.0526 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0141 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0467 | 0.3746 | 0.3621 |
Schistosoma mansoni | protein kinase | 0.0467 | 0.3746 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0466 | 0.3731 | 0.3605 |
Brugia malayi | Neuronal symmetry protein 1 | 0.0467 | 0.3746 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0467 | 0.3746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.3738 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (functional) | = 1 nM | Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of serotonin-induced cAMP accumulation by HTRF assay | ChEMBL. | 22926225 |
Ki (binding) | = 0.3 nM | Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr | ChEMBL. | 22926225 |
Ki (binding) | = 51 nM | Binding affinity to human dopamine D2L receptor expressed in HEK293 cells after 1 hr | ChEMBL. | 22926225 |
Ki (binding) | = 240 nM | Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr | ChEMBL. | 22926225 |
Ki (binding) | = 436 nM | Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr | ChEMBL. | 22926225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.