Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | sortilin, putative | 0.0423 | 0.6401 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.043 | 0.6533 | 1 |
Schistosoma mansoni | sortilin | 0.03 | 0.418 | 0.418 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.1009 | 0.1009 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.7358 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0623 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0476 | 0.7358 | 0.7358 |
Brugia malayi | Muscleblind-like protein | 0.0476 | 0.7358 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0067 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0623 | 1 | 1 |
Onchocerca volvulus | 0.0067 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.7358 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0067 | 0 | 0.5 |
Onchocerca volvulus | 0.0067 | 0 | 0.5 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0067 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0067 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0067 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0476 | 0.7358 | 0.7358 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0067 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0067 | 0 | 0.5 |
Toxoplasma gondii | sortilin, putative | 0.0423 | 0.6401 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0067 | 0 | 0.5 |
Onchocerca volvulus | 0.0067 | 0 | 0.5 | |
Echinococcus granulosus | sortilin | 0.0423 | 0.6401 | 0.6401 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0654 | 0.0654 |
Mycobacterium ulcerans | beta-lactamase | 0.0067 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0067 | 0 | 0.5 |
Plasmodium falciparum | sortilin | 0.0423 | 0.6401 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0067 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0067 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0654 | 0.0654 |
Mycobacterium ulcerans | hypothetical protein | 0.0067 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0476 | 0.7358 | 0.7358 |
Echinococcus multilocularis | sortilin | 0.0423 | 0.6401 | 0.6401 |
Trichomonas vaginalis | esterase, putative | 0.0067 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.