Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 735 aa | 23.7 % |
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 608 aa | 26.0 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.9 % |
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 629 aa | 26.4 % |
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 589 aa | 27.8 % |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 714 aa | 26.5 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 741 aa | 25.6 % |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 720 aa | 24.7 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 722 aa | 47.6 % | |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 630 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor | 0.0123 | 0.1406 | 0.1406 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0356 | 0.9035 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.2557 | 0.028 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0385 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0152 | 0.2371 | 0.3107 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0158 | 0.2557 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0158 | 0.2557 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0262 | 0.5964 | 0.4578 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0313 | 0.7629 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0158 | 0.2557 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0158 | 0.2557 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0158 | 0.2557 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0158 | 0.2557 | 0.3352 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0262 | 0.5964 | 0.4578 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.2557 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2557 | 0.2557 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0283 | 0.6665 | 0.8736 |
Loa Loa (eye worm) | glutamate receptor | 0.0313 | 0.7629 | 0.7629 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.2013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0262 | 0.5964 | 0.5392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.039 uM | Inhibition of pig PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide substrate | ChEMBL. | 23121075 |
IC50 (binding) | > 100 uM | Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 23121075 |
IC50 (binding) | > 100 uM | Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 23121075 |
IC50 (binding) | > 100 uM | Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique | ChEMBL. | 23121075 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.