Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0.00010709 | 0.000208378 | 0.000208821 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0.00010709 | 0.000208378 | 0.000208378 |
Schistosoma mansoni | hypothetical protein | 0.00010709 | 0.000208378 | 0.000208378 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0460211 | 0.997881 | 0.997881 |
Entamoeba histolytica | hypothetical protein | 0.0165905 | 0.358378 | 0.5 |
Brugia malayi | BTB/POZ domain containing protein | 0.00010709 | 0.000208378 | 0.000581449 |
Echinococcus granulosus | kelch protein 3 | 0.00010709 | 0.000208378 | 0.000208821 |
Entamoeba histolytica | hypothetical protein | 0.0165905 | 0.358378 | 0.5 |
Echinococcus granulosus | kelch protein 18 | 0.00010709 | 0.000208378 | 0.000208821 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.00010709 | 0.000208378 | 1 |
Echinococcus granulosus | kelch protein 10 | 0.000106946 | 0.000205258 | 0.000205694 |
Schistosoma mansoni | hypothetical protein | 0.00010709 | 0.000208378 | 0.000208378 |
Brugia malayi | Kelch-like protein X | 0.00010709 | 0.000208378 | 0.000581449 |
Entamoeba histolytica | hypothetical protein | 0.0165905 | 0.358378 | 0.5 |
Onchocerca volvulus | 0.0000974998 | 0 | 0.5 | |
Echinococcus multilocularis | kelch protein 12 | 0.00010709 | 0.000208378 | 0.000208378 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0460211 | 0.997881 | 1 |
Echinococcus multilocularis | kelch protein 10 | 0.000106946 | 0.000205258 | 0.000205258 |
Loa Loa (eye worm) | ring canal kelch protein | 0.00010709 | 0.000208378 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0165905 | 0.358378 | 0.5 |
Echinococcus multilocularis | kelch protein 18 | 0.00010709 | 0.000208378 | 0.000208378 |
Schistosoma mansoni | hypothetical protein | 0.000106946 | 0.000205258 | 0.000205258 |
Brugia malayi | Kelch motif family protein | 0.00010709 | 0.000208378 | 0.000581449 |
Schistosoma mansoni | hypothetical protein | 0.000106946 | 0.000205258 | 0.000205258 |
Schistosoma mansoni | hypothetical protein | 0.0461187 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.000106946 | 0.000205258 | 0.000205258 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0460211 | 0.997881 | 0.997881 |
Echinococcus granulosus | kelch protein 12 | 0.00010709 | 0.000208378 | 0.000208821 |
Brugia malayi | Kelch motif family protein | 0.00010709 | 0.000208378 | 0.000581449 |
Echinococcus multilocularis | kelch protein 3 | 0.00010709 | 0.000208378 | 0.000208378 |
Onchocerca volvulus | 0.0000974998 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.00010709 | 0.000208378 | 0.000208378 |
Loa Loa (eye worm) | Klhl5 protein | 0.00010709 | 0.000208378 | 1 |
Onchocerca volvulus | 0.0000974998 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0165905 | 0.358378 | 0.358378 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0461187 | 1 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0460211 | 0.997881 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0460211 | 0.997881 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0165905 | 0.358378 | 0.358378 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0165905 | 0.358378 | 0.359139 |
Brugia malayi | hypothetical protein | 0.0165905 | 0.358378 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0165905 | 0.358378 | 0.358378 |
Schistosoma mansoni | hypothetical protein | 0.00010709 | 0.000208378 | 0.000208378 |
Onchocerca volvulus | 0.0000974998 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10043 nM | Antimalarial activity against multidrug-sensitive Plasmodium falciparum NF54 | ChEMBL. | 23189922 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 23189922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.