Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.3781 | 0.3781 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.3781 | 0.5 |
Brugia malayi | hypothetical protein | 0.0183 | 0.3781 | 1 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Brugia malayi | BTB/POZ domain containing protein | 0.0001 | 0.0003 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0479 | 0.9972 | 0.9972 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.3781 | 0.5 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0479 | 0.9972 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0479 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0481 | 1 | 1 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Brugia malayi | Kelch-like protein X | 0.0001 | 0.0003 | 0.0007 |
Echinococcus granulosus | kelch protein 3 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0479 | 0.9972 | 0.9972 |
Echinococcus multilocularis | kelch protein 3 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 12 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 18 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 12 | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0479 | 0.9972 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0183 | 0.3781 | 0.3781 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | Klhl5 protein | 0.0001 | 0.0003 | 1 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0003 | 0.0007 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.3781 | 0.5 |
Echinococcus granulosus | kelch protein 10 | 0.0001 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Loa Loa (eye worm) | ring canal kelch protein | 0.0001 | 0.0003 | 1 |
Echinococcus granulosus | kelch protein 18 | 0.0001 | 0.0003 | 0.0003 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0003 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0001 | 0.0003 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0183 | 0.3781 | 0.3792 |
Echinococcus multilocularis | kelch protein 10 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0183 | 0.3781 | 0.3781 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 5 uM | Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay | ChEMBL. | 23116168 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23116168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.