Detailed information for compound 1718895

Basic information

Technical information
  • TDR Targets ID: 1718895
  • Name: 12H-quinoxalino[3,2-b][1,4]benzoxazine
  • MW: 235.241 | Formula: C14H9N3O
  • H donors: 1 H acceptors: 2 LogP: 3.22 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc2c(c1)Oc1c(N2)nc2c(n1)cccc2
  • InChi: 1S/C14H9N3O/c1-2-6-10-9(5-1)15-13-14(17-10)18-12-8-4-3-7-11(12)16-13/h1-8H,(H,15,16)
  • InChiKey: DVVDOLPZDYBCBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • AG-690/12884246
  • STOCK1S-93095
  • ZINC00161597
  • SR-01000516619-2
  • 12H-5-Oxa-6,11,12-triaza-naphthacene
  • BAS 00534726

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dihydroorotate dehydrogenase (quinone) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania mexicana dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania major dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium yoelii dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Babesia bovis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei gambiense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium berghei dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium falciparum dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Theileria parva dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania donovani dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma congolense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania infantum dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530 Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma mansoni dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Neospora caninum dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma japonicum ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative Get druggable targets OG5_127289 All targets in OG5_127289
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP dihydroorotate dehydrogenase (quinone) 395 aa 361 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.042 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0021 0.0021
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.02 0.1133 0.3704
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1718 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0021 0.0021
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.042 0.042
Schistosoma mansoni thyroid hormone receptor 0.001 0.0021 0.0188
Schistosoma mansoni dep domain containing protein 0.0009 0.0014 0.0127
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0073 0.0237
Brugia malayi hypothetical protein 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0021 0.0188
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 0.1133 0.1133
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0073 0.1727
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0223 0.1968
Schistosoma mansoni dihydroorotate dehydrogenase 0.02 0.1133 1
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0073 0.0641
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0021 0.0508
Trypanosoma cruzi kinesin, putative 0.0019 0.0073 0.0237
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0014 0.0343
Echinococcus multilocularis hypothetical protein 0.0019 0.0073 0.1727
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.053 0.3058 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0329 0.2901
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0021 0.0021
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0021 0.0021
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0014 0.0343
Loa Loa (eye worm) hypothetical protein 0.0062 0.0329 0.0329
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0021 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0021 0.0021
Echinococcus granulosus GPCR family 2 0.0015 0.0053 0.127
Schistosoma mansoni calpain (C02 family) 0.0019 0.0073 0.0641
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 0.1133 0.1133
Loa Loa (eye worm) hypothetical protein 0.0175 0.0985 0.0985
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0073 0.0237
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1718 1 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0014 0.0343
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0014 0.0014
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0078 0.042 0.1375
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0014 0.0343
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.1718 1 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0021 0.0508
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0223 0.5301
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0053 0.127
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1718 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0021 0.0021
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.042 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0021 0.0508
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0014 0.0014
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1718 1 1
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0021 0.0021
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0073 0.0641
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.02 0.1133 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.042 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0073 0.0237
Brugia malayi DIX domain containing protein 0.0009 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0021 0.0021
Schistosoma mansoni dishevelled 0.0009 0.0014 0.0127
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0078 0.042 0.042
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0021 0.0508
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0021 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0471
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0223 0.1968
Schistosoma mansoni coup transcription factor 0.001 0.0021 0.0188
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0021 0.0188
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0223 0.0223
Entamoeba histolytica protein kinase, putative 0.0019 0.0073 0.0073
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0021 0.0021
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0347 0.8257
Trypanosoma cruzi hypothetical protein, conserved 0.053 0.3058 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1718 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0073 0.0237
Brugia malayi calpain family protein 1 0.0062 0.0329 0.0329
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0014 0.0343
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.042 0.042
Brugia malayi calpain 7 0.0019 0.0073 0.0073
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0021 0.0508
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.02 0.1133 0.3551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0021 0.0021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0021 0.0508
Onchocerca volvulus 0.001 0.0021 0.0021
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.02 0.1133 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0246 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0021 0.0021
Schistosoma mansoni thyroid hormone receptor 0.001 0.0021 0.0188
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0223 0.1968
Trypanosoma cruzi kinesin, putative 0.0019 0.0073 0.0237
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.02 0.1133 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0223 0.5301
Loa Loa (eye worm) calpain family protein 1 0.0044 0.022 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0021 0.0021
Leishmania major dihydroorotate dehydrogenase 0.02 0.1133 0.3551
Onchocerca volvulus 0.0044 0.022 0.022
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.042 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.053 0.3058 1
Brugia malayi nuclear hormone receptor 0.001 0.0021 0.0021
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0021 0.0508
Schistosoma mansoni hypothetical protein 0.0033 0.0157 0.1385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0021 0.0508
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0021 0.0508
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0021 0.0508
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0021 0.0188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0246 0.0246
Loa Loa (eye worm) calpain 0.0019 0.0073 0.0073
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0014 0.0014
Brugia malayi nuclear receptor NHR-88 0.001 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor 0.001 0.0021 0.0188
Brugia malayi steroid hormone receptor 0.001 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0471
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0053 0.127
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0073 0.0641
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.053 0.3058 0.3058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0021 0.0021
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0073 0.0641
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.042 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0021 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0053 0.127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0021 0.0508
Brugia malayi calpain 5 0.0019 0.0073 0.0073
Leishmania major hypothetical protein, conserved 0.053 0.3058 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0021 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0021 0.0021
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0347 0.3065
Loa Loa (eye worm) hypothetical protein 0.0062 0.0329 0.0329
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0053 0.127
Echinococcus granulosus calpain A 0.0066 0.0347 0.8257
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0021 0.0188
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0021 0.0188
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0073 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0021 0.0021
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0014 0.0127
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0021 0.0188
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.053 0.3058 0.3058
Onchocerca volvulus 0.1718 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0073 0.0237
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.042 0.042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0073 0.0237
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0471
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0073 0.1727
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Brugia malayi Zinc finger, C2H2 type family protein 0.0078 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0044 0.022 0.022
Echinococcus multilocularis calpain 0.0019 0.0073 0.1727
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0223 0.0223
Brugia malayi hypothetical protein 0.0009 0.0014 0.0014
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0014 0.0343
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0053 0.0053
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0021 0.0508
Echinococcus multilocularis calpain A 0.0066 0.0347 0.8257
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1718 1 1
Echinococcus granulosus calpain 5 0.0019 0.0073 0.1727
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0021 0.0021
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.02 0.1133 0.5
Brugia malayi N-terminal motif family protein 0.0175 0.0985 0.0985
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.1718 1 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0347 0.8257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0053 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0223 0.5301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0223 0.5301
Loa Loa (eye worm) hypothetical protein 0.0044 0.022 0.022
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.02 0.1133 0.3704
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0246 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0021 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0021 0.0188
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0471
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0021 0.0508
Onchocerca volvulus 0.0009 0.0014 0.0014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0073 0.0237
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0021 0.0188
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0073 0.0237
Schistosoma mansoni dishevelled 0.0009 0.0014 0.0127
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.022 0.5235
Echinococcus multilocularis calpain 5 0.0019 0.0073 0.1727
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Plasmodium falciparum dihydroorotate dehydrogenase 0.02 0.1133 0.5
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1718 1 1
Loa Loa (eye worm) calpain family protein 1 0.0062 0.0329 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0021 0.0021
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.042 0.042
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0073 0.0237
Loa Loa (eye worm) calpain 5 0.0019 0.0073 0.0073
Brugia malayi ecdysteroid receptor 0.001 0.0021 0.0021
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0053 0.0053
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0985 0.0985
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1718 1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0014 0.0343
Brugia malayi calpain family protein 1 0.0062 0.0329 0.0329
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0021 0.0021
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1189 0.6906 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0347 0.3065
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0078 0.042 0.042
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0014 0.0127
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0014 0.0343
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0157 0.0157
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0014 0.0343
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.1718 1 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0014 0.0343
Echinococcus multilocularis GPCR, family 2 0.0015 0.0053 0.127
Echinococcus granulosus FTZ F1 alpha 0.001 0.0021 0.0508
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0014 0.0127
Echinococcus granulosus calpain A 0.0019 0.0073 0.1727
Echinococcus granulosus calpain 0.0019 0.0073 0.1727
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0021 0.0508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0021 0.0508
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.02 0.1133 0.3704

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18.28 uM Inhibition of human DHODH expressed in Escherichia coli BL21(DE3) using L-dihydroorotate as substrate after 10 mins by DCIP dye reduction assay ChEMBL. 22984987
Inhibition (binding) < 20 % Inhibition of Plasmodium falciparum DHODH expressed in Escherichia coli BL21 (DE3) using L-dihydroorotate as substrate at 10 uM after 10 mins by DCIP dye reduction assay ChEMBL. 22984987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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