Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Sus scrofa | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 376 aa | 25.5 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Candida albicans | similar to putative d-amino acid oxidase | D-amino-acid oxidase | 347 aa | 390 aa | 23.3 % |
Onchocerca volvulus | Unconventional prefoldin RPB5 interactor 1 homolog | D-amino-acid oxidase | 347 aa | 351 aa | 30.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0058 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0058 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | 0.0058 | 0 | 0.5 | |
Echinococcus granulosus | FTZ F1 alpha | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0058 | 0 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.039 | 0.4764 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0058 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.039 | 0.4764 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0058 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4764 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0058 | 0 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0058 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0058 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0058 | 0 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.039 | 0.4764 | 0.4764 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0058 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0058 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0058 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0058 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0357 | 0.4297 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0058 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay | ChEMBL. | 23243487 |
IC50 (binding) | = 0.8 uM | Inhibition of human recombinant DAAO expressed in HEK293 cells using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay | ChEMBL. | 23243487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.