Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sterol O-acyltransferase 1 | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | sterol O-acyltransferase 1 | 492 aa | 413 aa | 25.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0179 | 0.4107 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Brugia malayi | Protein kinase domain | 0.024 | 0.7379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.7252 | 0.7252 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0179 | 0.4107 | 0.2691 |
Schistosoma mansoni | serine/threonine protein kinase | 0.014 | 0.2043 | 0.2043 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.6749 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.029 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.014 | 0.2043 | 0.2043 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.014 | 0.2043 | 0.5 |
Brugia malayi | diacylglycerol acyltransferase | 0.0179 | 0.4107 | 0.5566 |
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0179 | 0.4107 | 0.4107 |
Schistosoma mansoni | protein kinase | 0.024 | 0.7379 | 0.7379 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.014 | 0.2043 | 0.2043 |
Entamoeba histolytica | p21-activated kinase | 0.024 | 0.7379 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.7379 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.014 | 0.2043 | 0.5 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.024 | 0.7379 | 0.6749 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.014 | 0.2043 | 0.2768 |
Giardia lamblia | Kinase, STE STE20 | 0.024 | 0.7379 | 0.5 |
Schistosoma mansoni | protein kinase | 0.024 | 0.7379 | 0.7379 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.029 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.024 | 0.7379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0179 | 0.4107 | 0.4107 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0179 | 0.4107 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0179 | 0.4107 | 0.5 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.014 | 0.2043 | 0.2043 |
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.7379 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.6749 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0179 | 0.4107 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1359 | 0.1359 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.014 | 0.2043 | 0.2768 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 0.7274 | 0.9857 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.7274 | 0.7274 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0179 | 0.4107 | 0.4107 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.024 | 0.7379 | 0.7379 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 1.3 % | Fraction unbound in human plasma at 37 degC by LC-UV/MS method based equilibrium dialysis method | ChEMBL. | 23116186 |
IC50 (binding) | = 0.03 uM | Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography | ChEMBL. | 23116186 |
IC50 (binding) | = 2.4 uM | Inhibition of human ACAT1 by liquid scintillography | ChEMBL. | 23116186 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.