Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0005 | 0.0083 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.016 | 0.249 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0005 | 0.0035 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0005 | 0.0005 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0725 | 0.3056 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.003 | 0.0196 |
Echinococcus granulosus | calpain 7 C02 family | 0.002 | 0.0045 | 0.0293 |
Echinococcus multilocularis | calpain 5 | 0.002 | 0.0045 | 0.0293 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0081 | 0.0305 | 0.4743 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0066 | 0.0242 | 0.3751 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.003 | 0.0465 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.016 | 0.1051 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0005 | 0.0035 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0005 | 0.0083 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.016 | 0.1051 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0005 | 0.0035 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0167 | 0.0673 | 0.441 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | calpain (C02 family) | 0.002 | 0.0045 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0005 | 0.0035 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.2351 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.0256 | 0.3974 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.002 | 0.0045 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0178 | 0.0178 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.016 | 0.016 |
Onchocerca volvulus | 0.2351 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0005 | 0.0005 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.2351 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | calpain 5 | 0.002 | 0.0045 | 0.0045 |
Echinococcus granulosus | calpain 5 | 0.002 | 0.0045 | 0.0293 |
Echinococcus granulosus | calpain A | 0.0069 | 0.0256 | 0.1677 |
Echinococcus granulosus | calpain A | 0.002 | 0.0045 | 0.0293 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0005 | 0.0083 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0167 | 0.0673 | 0.441 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0066 | 0.0242 | 0.0242 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.002 | 0.0045 | 0.0695 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.003 | 0.0196 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.2351 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0242 | 0.0242 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0005 | 0.0035 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.016 | 0.016 |
Brugia malayi | Cache domain containing protein | 0.0074 | 0.0276 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0329 | 0.5108 |
Plasmodium vivax | calpain, putative | 0.002 | 0.0045 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0005 | 0.0035 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | calpain 7 (C02 family) | 0.002 | 0.0045 | 0.0293 |
Schistosoma mansoni | serine-rich repeat protein | 0.0086 | 0.0329 | 0.5108 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0005 | 0.0083 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.003 | 0.003 |
Echinococcus granulosus | calpain | 0.002 | 0.0045 | 0.0293 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.016 | 0.249 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0367 | 0.1526 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0005 | 0.0005 |
Leishmania major | hypothetical protein, conserved | 0.0725 | 0.3056 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0005 | 0.0083 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0069 | 0.0256 | 0.1677 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0005 | 0.0005 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0005 | 0.0035 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0005 | 0.0083 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.003 | 0.0465 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0178 | 0.0178 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0005 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.003 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0178 | 0.0178 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0005 | 0.0005 |
Brugia malayi | calpain family protein 1 | 0.0066 | 0.0242 | 0.0242 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0005 | 0.0083 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.2351 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0046 | 0.0158 | 0.0158 | |
Echinococcus multilocularis | calpain A | 0.0069 | 0.0256 | 0.1677 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.002 | 0.0045 | 0.0695 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0005 | 0.0035 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.0256 | 0.1677 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0005 | 0.0035 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.2351 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0005 | 0.0035 |
Onchocerca volvulus | 0.001 | 0.0005 | 0.0005 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0178 | 0.0178 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.016 | 0.249 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.003 | 0.0196 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.1626 | 0.6906 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.016 | 0.1051 |
Echinococcus multilocularis | hypothetical protein | 0.002 | 0.0045 | 0.0293 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0005 | 0.0005 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0005 | 0.0035 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.0256 | 0.3974 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | calpain | 0.002 | 0.0045 | 0.0293 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.003 | 0.0465 |
Loa Loa (eye worm) | calpain | 0.002 | 0.0045 | 0.0045 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0725 | 0.3056 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.2351 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0367 | 0.1526 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | calpain C (C02 family) | 0.002 | 0.0045 | 0.0695 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0046 | 0.0158 | 0.1037 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0005 | 0.0035 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0005 | 0.0035 |
Brugia malayi | calpain 5 | 0.002 | 0.0045 | 0.0045 |
Brugia malayi | calpain 7 | 0.002 | 0.0045 | 0.0045 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0747 | 0.0747 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0005 | 0.0035 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.003 | 0.0196 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0005 | 0.0005 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.003 | 0.0196 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.011 | 0.1702 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.2351 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0005 | 0.0083 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0005 | 0.0005 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0005 | 0.0035 |
Brugia malayi | N-terminal motif family protein | 0.0184 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0046 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0276 | 0.0276 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.016 | 0.0644 | 1 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0005 | 0.0005 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.2351 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.003 | 0.003 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0005 | 0.0083 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0005 | 0.0035 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.2351 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0725 | 0.3056 | 1 |
Brugia malayi | calpain family protein 1 | 0.0066 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.003 | 0.003 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0184 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0005 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0158 | 0.0158 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0005 | 0.0083 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.2351 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0005 | 0.0035 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0005 | 0.0005 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.003 | 0.0196 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.016 | 0.1051 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.2351 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0005 | 0.0083 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0005 | 0.0083 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of human recombinant SIRT1 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant SIRT2 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.