Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0411 | 0.0153 | 0.0153 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0922 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0922 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0518 | 0.2217 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0922 | 1 | 1 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0518 | 0.2217 | 0.2217 |
Entamoeba histolytica | p21-activated kinase | 0.0922 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0411 | 0.0153 | 0.0153 |
Schistosoma mansoni | protein kinase | 0.0922 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0518 | 0.2217 | 0.2252 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0518 | 0.2217 | 0.2096 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0518 | 0.2217 | 0.2217 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0922 | 1 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0518 | 0.2217 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0922 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0922 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0922 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0922 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0922 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0518 | 0.2217 | 0.2252 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0914 | 0.9847 | 0.9844 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0779 | 0.7236 | 0.7349 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0922 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0518 | 0.2217 | 0.2217 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.9847 | 1 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0779 | 0.7236 | 0.7236 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.051 | 0.2064 | 0.2064 |
Trichomonas vaginalis | STE family protein kinase | 0.0922 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0411 | 0.0153 | 0.0153 |
Entamoeba histolytica | protein kinase, putative | 0.0411 | 0.0153 | 0.0153 |
Schistosoma mansoni | protein kinase | 0.0922 | 1 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0411 | 0.0153 | 0.0153 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0922 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.1 nM | Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assay | ChEMBL. | 23067318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.