Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0179 | 0.4107 | 0.5 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.014 | 0.2043 | 0.2043 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.6749 |
Schistosoma mansoni | serine/threonine protein kinase | 0.014 | 0.2043 | 0.2043 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.014 | 0.2043 | 0.2768 |
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0179 | 0.4107 | 0.4107 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.014 | 0.2043 | 0.2043 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0179 | 0.4107 | 0.5 |
Entamoeba histolytica | p21-activated kinase | 0.024 | 0.7379 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0179 | 0.4107 | 0.4107 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.7379 |
Schistosoma mansoni | protein kinase | 0.024 | 0.7379 | 0.7379 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0179 | 0.4107 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.024 | 0.7379 | 0.5 |
Brugia malayi | Protein kinase domain | 0.024 | 0.7379 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.024 | 0.7379 | 0.7379 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.014 | 0.2043 | 0.2768 |
Schistosoma mansoni | protein kinase | 0.024 | 0.7379 | 0.7379 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1359 | 0.1359 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0179 | 0.4107 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.014 | 0.2043 | 0.2043 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.7274 | 0.7274 |
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.6749 |
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.024 | 0.7379 | 0.6749 |
Entamoeba histolytica | protein kinase, putative | 0.024 | 0.7379 | 1 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.029 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.014 | 0.2043 | 0.5 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.029 | 1 | 1 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0179 | 0.4107 | 0.4107 |
Trichomonas vaginalis | STE family protein kinase | 0.024 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 0.7274 | 0.9857 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0179 | 0.4107 | 0.2691 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.024 | 0.7379 | 0.7379 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.7252 | 0.7252 |
Brugia malayi | diacylglycerol acyltransferase | 0.0179 | 0.4107 | 0.5566 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.014 | 0.2043 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.17 uM | Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography | ChEMBL. | 23116186 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.