Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.32 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (binding) | = 0.48 uM | Concentration required for in vitro inhibition of thymidylate synthase | ChEMBL. | 2231606 |
IC50 (binding) | = 0.48 uM | Concentration required for in vitro inhibition of thymidylate synthase | ChEMBL. | 2231606 |
IC50 (functional) | = 125 uM | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | ChEMBL. | 2231606 |
IC50 (functional) | = 125 uM | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | ChEMBL. | 2231606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.