Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | AGC kinase | 0.0036 | 0.0023 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1132 | 0.1111 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.2259 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.0023 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0111 | 0.2259 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.9683 | 0.9682 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.005 | 0.0436 | 0.0413 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0063 | 0.0833 | 0.0812 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0063 | 0.0833 | 0.3624 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0085 | 0.1494 | 0.6579 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0036 | 0.0023 | 0.5 |
Schistosoma mansoni | atypical protein kinase C | 0.0062 | 0.0788 | 0.3421 |
Brugia malayi | protein kinase C II. | 0.0063 | 0.0833 | 0.6881 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0367 | 0.0345 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.0023 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0062 | 0.0788 | 0.3421 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.2259 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.0367 | 0.1538 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0063 | 0.0833 | 0.3624 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.8919 | 0.8916 |
Echinococcus multilocularis | protein kinase c iota type | 0.0062 | 0.0788 | 0.3421 |
Echinococcus granulosus | protein kinase C gamma type | 0.0085 | 0.1494 | 0.6579 |
Brugia malayi | Protein kinase c protein 2 | 0.0075 | 0.12 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.8919 | 0.8916 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.0367 | 0.1538 |
Onchocerca volvulus | 0.0333 | 0.8919 | 0.5 | |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.0367 | 0.1538 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.0023 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.0023 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.8919 | 0.8916 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0111 | 0.2259 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0063 | 0.0833 | 0.3624 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.0023 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of PKC-theta in human PBMC cells assessed as inhibition of IL-2 after 24 hrs by bead-based FLISA assay | ChEMBL. | 23398373 |
Ki (binding) | = 0.1 nM | Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP | ChEMBL. | 23398373 |
Ki (binding) | < 10 nM | Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 15 mins by spectrophotometry in presence of ATP | ChEMBL. | 23398373 |
Ki (binding) | = 56 nM | Inhibition of PKC alpha (unknown origin) using RRRRRKGSFKRKA as substrate after 15 mins by spectrophotometry in presence of ATP | ChEMBL. | 23398373 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.