TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 329.478 | Formula: C24H27N
H donors: 1 H acceptors: 0 LogP: 5.88 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: NCCCC(c1cccc(c1)CC)(c1ccccc1)c1ccccc1
InChi: 1S/C24H27N/c1-2-20-11-9-16-23(19-20)24(17-10-18-25,21-12-5-3-6-13-21)22-14-7-4-8-15-22/h3-9,11-16,19H,2,10,17-18,25H2,1H3
InChiKey: IXVMCANTGMOZNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinesin family member 11	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	kinesin family 1	Get druggable targets OG5_128460	All targets in OG5_128460
Cryptosporidium hominis	kinesin-like boursin	Get druggable targets OG5_128460	All targets in OG5_128460
Candida albicans	kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein	Get druggable targets OG5_128460	All targets in OG5_128460
Entamoeba histolytica	kinesin, putative	Get druggable targets OG5_128460	All targets in OG5_128460
Plasmodium yoelii	Kinesin motor domain, putative	Get druggable targets OG5_128460	All targets in OG5_128460
Schistosoma mansoni	kinesin eg-5	Get druggable targets OG5_128460	All targets in OG5_128460
Plasmodium vivax	kinesin-5	Get druggable targets OG5_128460	All targets in OG5_128460
Giardia lamblia	Kinesin-5	Get druggable targets OG5_128460	All targets in OG5_128460
Loa Loa (eye worm)	kinesin-like protein KLP2	Get druggable targets OG5_128460	All targets in OG5_128460
Plasmodium falciparum	kinesin-5	Get druggable targets OG5_128460	All targets in OG5_128460
Toxoplasma gondii	kinesin motor domain-containing protein	Get druggable targets OG5_128460	All targets in OG5_128460
Neospora caninum	hypothetical protein	Get druggable targets OG5_128460	All targets in OG5_128460
Plasmodium knowlesi	kinesin-5, putative	Get druggable targets OG5_128460	All targets in OG5_128460
Echinococcus multilocularis	kinesin family 1	Get druggable targets OG5_128460	All targets in OG5_128460
Cryptosporidium parvum	kinesin-like boursin, putative	Get druggable targets OG5_128460	All targets in OG5_128460
Schistosoma japonicum	ko:K10398 kinesin family member 11, putative	Get druggable targets OG5_128460	All targets in OG5_128460
Candida albicans	kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein	Get druggable targets OG5_128460	All targets in OG5_128460
Plasmodium berghei	kinesin-5, putative	Get druggable targets OG5_128460	All targets in OG5_128460
Brugia malayi	Kinesin motor domain containing protein	Get druggable targets OG5_128460	All targets in OG5_128460

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0088
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0014	0.0059	0.0961
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0014	0.0059	0.0218
Loa Loa (eye worm)	cytochrome P450 family protein	0.0038	0.0329	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0309	0.0975
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0047	0.0479
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0088
Trichomonas vaginalis	helicase, putative	0.0013	0.0047	0.0479
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Echinococcus multilocularis	nibrin	0.0011	0.0028	0.0028
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0353	0.0437
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.0137	0.1439	1
Trichomonas vaginalis	mercuric reductase, putative	0.0014	0.0059	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0057	0.055	0.1732
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0028	0.0088
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0059	0.0218
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0059	0.0218
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0061	0.0075
Schistosoma mansoni	hypothetical protein	0.0215	0.2325	0.2875
Schistosoma mansoni	topbp1	0.0011	0.0028	0.0035
Echinococcus multilocularis	Niemann Pick C1 protein	0.0109	0.1131	0.1131
Echinococcus multilocularis	dnaJ subfamily B	0.0341	0.3732	0.3732
Loa Loa (eye worm)	histone methyltransferase	0.0017	0.0099	0.0313
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Schistosoma mansoni	cpg binding protein	0.0059	0.0567	0.0702
Echinococcus multilocularis	protein patched	0.0047	0.0431	0.0431
Giardia lamblia	Kinesin-5	0.0032	0.0267	1
Entamoeba histolytica	hypothetical protein	0.004	0.0353	0.2949
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0014	0.0059	0.069
Echinococcus multilocularis	Niemann Pick C1 protein	0.0156	0.1657	0.1657
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.009	0.0914	0.8837
Echinococcus granulosus	microtubule associated protein 2	0.0728	0.8086	1
Echinococcus multilocularis	expressed conserved protein	0.0102	0.1057	0.1057
Entamoeba histolytica	hypothetical protein	0.004	0.0353	0.2949
Leishmania major	ferric reductase, putative	0.0137	0.1439	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0109	0.1131	0.3564
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0059	0.0218
Schistosoma mansoni	hypothetical protein	0.0045	0.0412	0.051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0496	0.1564
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0059	1
Leishmania major	trypanothione reductase	0.0039	0.0348	0.2094
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0028	0.0000032534
Echinococcus multilocularis	protein dispatched 1	0.0053	0.0506	0.0506
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0059	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0353	0.0437
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.009	0.0914	0.8837
Mycobacterium tuberculosis	Probable oxidoreductase	0.01	0.1027	1
Echinococcus multilocularis	neuropeptide s receptor	0.0385	0.4231	0.4231
Trichomonas vaginalis	glutathione reductase, putative	0.0014	0.0059	0.0761
Echinococcus multilocularis	kinesin family 1	0.0247	0.2686	0.2686
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0088
Echinococcus granulosus	tumor protein p63	0.0374	0.4112	0.5085
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0348	0.2985
Brugia malayi	Kinesin motor domain containing protein	0.0032	0.0267	0.084
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0038	0.0333	0.105
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0061	0.0061
Brugia malayi	Cytochrome P450 family protein	0.0038	0.0329	0.1036
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0496	0.1564
Echinococcus granulosus	neuropeptide receptor A26	0.0385	0.4231	0.5233
Plasmodium falciparum	thioredoxin reductase	0.0014	0.0059	0.0961
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Echinococcus multilocularis	tumor protein p63	0.0374	0.4112	0.4112
Echinococcus multilocularis	microtubule associated protein 2	0.0728	0.8086	0.8086
Echinococcus granulosus	expressed conserved protein	0.0102	0.1057	0.1307
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.0333	0.0412
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0348	0.1096
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0028	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Toxoplasma gondii	kinesin motor domain-containing protein	0.0032	0.0267	0.2243
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0333	0.0412
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0014	0.0059	0.069
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0431	1
Schistosoma mansoni	topbp1	0.0011	0.0028	0.0035
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0051	0.0473	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0028	0.000008579
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0018	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0431	0.1359
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0059	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0047	0.0479
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0348	0.0348
Mycobacterium tuberculosis	Probable dehydrogenase	0.009	0.0914	0.8837
Schistosoma mansoni	hypothetical protein	0.0045	0.0412	0.051
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0059	0.0218
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.0333	0.0333
Echinococcus granulosus	Niemann Pick C1 protein	0.0109	0.1131	0.1399
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0028	0.0035
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.0333	0.0333
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0028	0.000008579
Schistosoma mansoni	hypothetical protein	0.0017	0.0092	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0154	0.164	0.5167
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0088
Mycobacterium tuberculosis	Probable reductase	0.009	0.0914	0.8837
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.0137	0.1439	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0028	0.000008579
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.01	0.1027	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0051	0.0473	0.0586
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0014	0.0059	0.069
Schistosoma mansoni	microtubule-associated protein tau	0.0728	0.8086	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0521	0.1642
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.009	0.0914	0.8837
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0014	0.0059	0.1287
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0092	0.0114
Echinococcus granulosus	Niemann Pick C1 protein	0.0156	0.1657	0.2049
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0088
Schistosoma mansoni	cpg binding protein	0.0059	0.0567	0.0702
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0051	0.0473	1
Trypanosoma brucei	ferric reductase transmembrane protein, putative	0.0137	0.1439	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0051	0.0473	0.0586
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0088
Onchocerca volvulus		0.0055	0.0521	0.1642
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0051	0.0473	0.0586
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0496	0.1564
Onchocerca volvulus		0.0011	0.0028	0.0088
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0051	0.0473	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0333	0.0412
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0014	0.0059	0.0961
Schistosoma mansoni	hypothetical protein	0.0017	0.0092	0.0114
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0059	0.0059
Schistosoma mansoni	DNA ligase IV	0.0011	0.0028	0.0035
Echinococcus granulosus	neuropeptide s receptor	0.0385	0.4231	0.5233
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0032	0.0267	0.084
Schistosoma mansoni	kinesin eg-5	0.0032	0.0267	0.033
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0018	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0051	0.0473	0.4283
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.0532	0.1675
Echinococcus granulosus	cpg binding protein	0.0059	0.0567	0.0702
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0092	0.0092
Brugia malayi	Thioredoxin reductase	0.0039	0.0348	0.1096
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0106	0.1092	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0092	0.0114
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0028	0.0000031374
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.0431	0.0534
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0028	0.0088
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0014	0.0059	0.0289
Brugia malayi	CXXC zinc finger family protein	0.0056	0.0532	0.1675
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0097	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0088
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0047	0.0479
Entamoeba histolytica	hypothetical protein	0.0039	0.0343	0.2859
Echinococcus multilocularis	neuropeptide receptor A26	0.0385	0.4231	0.4231
Echinococcus granulosus	kinesin family 1	0.0247	0.2686	0.3322
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0047	0.0479
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0348	0.1096
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0028	0.0088
Entamoeba histolytica	hypothetical protein	0.004	0.0353	0.2949
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0059	0.0218
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0092	0.0291
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0348	1
Schistosoma mansoni	patched 1	0.0047	0.0431	0.0534
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.0099	0.0099
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.009	0.0914	0.8873
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0051	0.0473	0.3004
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0059	0.0218
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.0431	0.0431
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0348	0.043
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0014	0.0059	0.0961
Schistosoma mansoni	hypothetical protein	0.0017	0.0092	0.0114
Echinococcus granulosus	nibrin	0.0011	0.0028	0.0035
Echinococcus granulosus	GPCR family 2	0.0017	0.0092	0.0114
Plasmodium falciparum	kinesin-5	0.0032	0.0267	0.7463
Toxoplasma gondii	aldehyde dehydrogenase	0.0051	0.0473	0.4187
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.01	0.1027	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0059	0.0185
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0059	0.0218
Schistosoma mansoni	hypothetical protein	0.004	0.0353	0.0437
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0109	0.1131	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0059	0.0073
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0047	0.0479
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0059	0.0218
Treponema pallidum	hypothetical protein	0.0039	0.0343	1
Echinococcus multilocularis	cpg binding protein	0.0059	0.0567	0.0567
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0038	0.0333	0.105
Brugia malayi	Blistered cuticle protein 3	0.0291	0.3173	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0092	0.0291
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0051	0.0473	0.0473
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0061	0.0075
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.0099	0.0123
Schistosoma mansoni	cpg binding protein	0.0056	0.0532	0.0657
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0496	0.1564
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0353	0.0353
Brugia malayi	hypothetical protein	0.004	0.0353	0.1113
Schistosoma mansoni	hypothetical protein	0.0341	0.3732	0.4615
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0014	0.0059	0.0218
Brugia malayi	CHE-14 protein	0.0047	0.0431	0.1359
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Brugia malayi	glutathione reductase	0.0039	0.0348	0.1096
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0309	0.0975
Trypanosoma brucei	trypanothione reductase	0.0039	0.0348	0.2266
Loa Loa (eye worm)	blistered cuticle protein 3	0.0291	0.3173	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0118	0.1234	0.1526
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0047	0.0479
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0348	0.3006
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1131	0.3564
Schistosoma mansoni	cellular tumor antigen P53	0.0055	0.0521	0.0644
Toxoplasma gondii	NADPH-glutathione reductase	0.0014	0.0059	0.0289
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0047	0.0479
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0014	0.0059	0.0961
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0092	0.0092
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.0431	0.1359
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0059	0.0218
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0059	0.0218
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0047	0.0479
Plasmodium falciparum	glutathione reductase	0.0039	0.0348	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0092	0.0114
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0092	0.0291
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.0431	0.0534
Trypanosoma cruzi	trypanothione reductase, putative	0.0014	0.0059	0.0218
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0111	0.115	0.1422
Brugia malayi	topoisomerase	0.0011	0.0028	0.0088
Schistosoma mansoni	hypothetical protein	0.0045	0.0412	0.051
Onchocerca volvulus		0.0056	0.0532	0.1675
Schistosoma mansoni	hypothetical protein	0.0036	0.0309	0.0383
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0092	0.0092
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.01	0.1027	1
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0348	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0092	0.0291
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0333	0.0412
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0061	0.0061
Echinococcus granulosus	dnaJ subfamily B	0.0341	0.3732	0.4615
Entamoeba histolytica	kinesin, putative	0.0032	0.0267	0.2163
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0348	1
Treponema pallidum	NADH oxidase	0.0014	0.0059	0.0974
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0047	0.0479
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.0333	0.0412
Entamoeba histolytica	hypothetical protein	0.004	0.0353	0.2949
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.009	0.0914	0.8837
Plasmodium falciparum	glutathione reductase	0.0014	0.0059	0.0961
Plasmodium vivax	kinesin-5	0.0032	0.0267	0.7463
Onchocerca volvulus	Dual oxidase homolog	0.0291	0.3173	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0059	0.0073
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0061	0.0075
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0045	0.0412	0.051
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0348	0.2266

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= 305 nM	Growth inhibition of human K562 cells after 72 hrs by Alamar blue assay	ChEMBL.	23394180
Ki (binding)	= 6.4 nM	Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (DE3) by pyruvate kinase/lactate dehydrogenase-coupled assay	ChEMBL.	23394180

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2325432

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1728406