Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | D-amino acid oxidase | Starlite/ChEMBL | References |
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Rattus norvegicus | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to putative d-amino acid oxidase | D-amino-acid oxidase | 346 aa | 388 aa | 22.2 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino acid oxidase | 345 aa | 381 aa | 23.4 % |
Onchocerca volvulus | Unconventional prefoldin RPB5 interactor 1 homolog | D-amino-acid oxidase | 346 aa | 350 aa | 31.1 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 346 aa | 382 aa | 24.1 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0361 | 0.188 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0584 | 0.3331 | 1 |
Schistosoma mansoni | d-amino acid oxidase | 0.0584 | 0.3331 | 0.3331 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0361 | 0.188 | 1 |
Echinococcus granulosus | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0361 | 0.188 | 0.188 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0584 | 0.3331 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Giardia lamblia | Hypothetical protein | 0.0361 | 0.188 | 1 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0536 | 0.3014 | 1 |
Loa Loa (eye worm) | deoxynucleoside kinase | 0.0361 | 0.188 | 0.5644 |
Giardia lamblia | Hypothetical protein | 0.0361 | 0.188 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0361 | 0.188 | 1 |
Giardia lamblia | Deoxynucleoside kinase | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Echinococcus multilocularis | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0361 | 0.188 | 0.188 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0361 | 0.188 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0361 | 0.188 | 0.188 |
Giardia lamblia | Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative | 0.0361 | 0.188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0584 | 0.3331 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0361 | 0.188 | 1 |
Brugia malayi | Deoxynucleoside kinase family protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0361 | 0.188 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0361 | 0.188 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0361 | 0.188 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 nM | Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
IC50 (binding) | = 4.4 nM | Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
IC50 (binding) | = 5.6 nM | Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
IC50 (binding) | = 8.8 nM | Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.