Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.00892737 | 0.522996 | 0.522996 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.00688851 | 0.376343 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00688851 | 0.376343 | 1 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0155589 | 1 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.00892737 | 0.522996 | 0.522996 |
Loa Loa (eye worm) | haspin protein kinase | 0.00892737 | 0.522996 | 0.522996 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0155589 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155589 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0155589 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155589 | 1 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.00688851 | 0.376343 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.00688851 | 0.376343 | 0.376343 |
Schistosoma mansoni | hypothetical protein | 0.0155589 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00688851 | 0.376343 | 1 |
Brugia malayi | GSG2 | 0.00892737 | 0.522996 | 0.522996 |
Echinococcus granulosus | dual specificity | 0.00688851 | 0.376343 | 0.376343 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.00892737 | 0.522996 | 0.522996 |
Entamoeba histolytica | protein kinase, putative | 0.00688851 | 0.376343 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00688851 | 0.376343 | 1 |
Plasmodium falciparum | conserved protein, unknown function | 0.0155589 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00688851 | 0.376343 | 0.376343 |
Onchocerca volvulus | 0.0155589 | 1 | 0.5 | |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.00688851 | 0.376343 | 0.376343 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.00892737 | 0.522996 | 0.522996 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00688851 | 0.376343 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00688851 | 0.376343 | 1 |
Onchocerca volvulus | 0.0155589 | 1 | 0.5 | |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.00892737 | 0.522996 | 0.522996 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.00688851 | 0.376343 | 1 |
Echinococcus multilocularis | dual specificity | 0.00688851 | 0.376343 | 0.376343 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0155589 | 1 | 1 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.00688851 | 0.376343 | 1 |
Schistosoma mansoni | hypothetical protein | 0.00892737 | 0.522996 | 0.522996 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00688851 | 0.376343 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.00688851 | 0.376343 | 1 |
Echinococcus granulosus | dual specificity | 0.00688851 | 0.376343 | 0.376343 |
Loa Loa (eye worm) | haspin protein kinase | 0.00897191 | 0.5262 | 0.5262 |
Echinococcus multilocularis | dual specificity | 0.00688851 | 0.376343 | 0.376343 |
Brugia malayi | hypothetical protein | 0.00892737 | 0.522996 | 0.522996 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.00892737 | 0.522996 | 0.522996 |
Echinococcus granulosus | dual specificity | 0.00688851 | 0.376343 | 0.376343 |
Toxoplasma gondii | hypothetical protein | 0.0155589 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.00688851 | 0.376343 | 0.376343 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 77 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 24 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax | ChEMBL. | 23260352 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 23260352 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.