Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Average (functional) | = 31 % | In vivo inhibition of ornithine de-carboxylase (ODC) activity induced by 12-0-tetradecanoylphorbol 13-acetate (TPA) in mouse skin | ChEMBL. | 7932527 |
Average (functional) | = 31 % | In vivo inhibition of ornithine de-carboxylase (ODC) activity induced by 12-0-tetradecanoylphorbol 13-acetate (TPA) in mouse skin | ChEMBL. | 7932527 |
Control (functional) | = 68 % | Inhibition of TPA-induced ODC activity as percentage of the average no. of papillomas / mouse in groups of control mice was determined using papilloma assay | ChEMBL. | 7932527 |
Control (functional) | = 68 % | Inhibition of TPA-induced ODC activity as percentage of the average no. of papillomas / mouse in groups of control mice was determined using papilloma assay | ChEMBL. | 7932527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.