Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.036 | 0.883 | 0.8457 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.5867 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.5867 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.036 | 0.883 | 0.883 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.883 | 0.883 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.5867 | 1 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0184 | 0.3826 | 0.1855 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3624 | 0.1027 |
Echinococcus granulosus | geminin | 0.0168 | 0.3367 | 0.5 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Leishmania major | phospholipase A1, putative | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.3827 | 0.3827 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0402 | 1 | 1 |
Giardia lamblia | DNA repair protein RAD52 | 0.0345 | 0.8384 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.5867 | 1 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0184 | 0.3826 | 0.1855 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.5867 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3367 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0256 | 0.5867 | 0.5867 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0256 | 0.5867 | 0.5867 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0345 | 0.8384 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.036 | 0.883 | 0.8457 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3367 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0402 | 1 | 1 |
Trypanosoma brucei | phospholipase A1, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.5867 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0168 | 0.3367 | 0.125 |
Echinococcus multilocularis | geminin | 0.0168 | 0.3367 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.036 | 0.883 | 0.8457 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3624 | 0.1027 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0402 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26 nM | Inhibition of human plasma Lp-PLA2 using 2- thio-PAF as substrate incubated for 20 mins prior to substrate addition measured after 1 hr | ChEMBL. | 23333209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.