Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0369 | 1 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0369 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0369 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0369 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0369 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0369 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0369 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0369 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.81 uM | Inhibition of AChE (unknown origin) using acetylthiocholine iodide substrate by Ellman's method based spectrophotometry | ChEMBL. | 23454132 |
IC50 (binding) | = 11.81 uM | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | ChEMBL. | 23570788 |
IC50 (binding) | = 54.04 uM | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride substrate by Ellman's method based spectrophotometry | ChEMBL. | 23454132 |
IC50 (binding) | = 54.04 uM | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | ChEMBL. | 23570788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.