Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0139 | 0.3022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2141 | 0.2141 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0055 | 0.0787 | 0.0787 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Trypanosoma brucei | phospholipase A1, putative | 0.0402 | 1 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.0032 | 0.018 | 0.0596 |
Brugia malayi | WGR domain containing protein | 0.0076 | 0.136 | 0.136 |
Leishmania major | phospholipase A1, putative | 0.0402 | 1 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0066 | 0.1087 | 0.3596 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0144 | 0.3166 | 0.5 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0076 | 0.136 | 0.4501 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0402 | 1 | 1 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0139 | 0.3022 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0076 | 0.136 | 0.4501 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.136 | 0.136 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0184 | 0.4225 | 0.3316 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0184 | 0.4225 | 0.3316 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0076 | 0.136 | 0.4501 |
Echinococcus granulosus | WGR domain containing protein | 0.0043 | 0.0479 | 0.1586 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0043 | 0.0479 | 0.1586 |
Brugia malayi | WGR domain containing protein | 0.0139 | 0.3022 | 0.3022 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0139 | 0.3022 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0139 | 0.3022 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 39 nM | Inhibition of human plasma Lp-PLA2 using 2- thio-PAF as substrate incubated for 20 mins prior to substrate addition measured after 1 hr | ChEMBL. | 23333209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.