Detailed information for compound 1732989

Basic information

Technical information
  • TDR Targets ID: 1732989
  • Name: 1-[6-[[4-(4-fluorophenyl)-1-methylpiperidin-4 -yl]methoxymethyl]-4-(trifluoromethyl)pyridin -2-yl]piperidine-4-carbonitrile
  • MW: 490.536 | Formula: C26H30F4N4O
  • H donors: 0 H acceptors: 2 LogP: 4.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1CCN(CC1)c1nc(COCC2(CCN(CC2)C)c2ccc(cc2)F)cc(c1)C(F)(F)F
  • InChi: 1S/C26H30F4N4O/c1-33-12-8-25(9-13-33,20-2-4-22(27)5-3-20)18-35-17-23-14-21(26(28,29)30)15-24(32-23)34-10-6-19(16-31)7-11-34/h2-5,14-15,19H,6-13,17-18H2,1H3
  • InChiKey: SPLKTVKAAPXPPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[6-[[4-(4-fluorophenyl)-1-methyl-4-piperidyl]methoxymethyl]-4-(trifluoromethyl)-2-pyridyl]piperidine-4-carbonitrile
  • 1-[6-[[4-(4-fluorophenyl)-1-methyl-4-piperidinyl]methoxymethyl]-4-(trifluoromethyl)-2-pyridyl]-4-piperidinecarbonitrile
  • 1-[6-[[4-(4-fluorophenyl)-1-methyl-4-piperidyl]methoxymethyl]-4-(trifluoromethyl)-2-pyridyl]isonipecotonitrile
  • 1-[6-[[4-(4-fluorophenyl)-1-methyl-piperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridin-2-yl]piperidine-4-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0143 0.1104 0.2586
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0143 0.1104 0.2149
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0196 0.1698 0.2796
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0143 0.1104 0.1104
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Loa Loa (eye worm) serotonin transporter b 0.0073 0.032 0.0526
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1566 0.3309
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2667 0.5638
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0143 0.1104 0.2149
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0143 0.1104 0.2586
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0143 0.1104 0.2333
Echinococcus granulosus serotonin transporter 0.0073 0.032 0.032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0506 0.517 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0143 0.1104 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0143 0.1104 0.2149
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.036 0.3535 0.3535
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0287 0.2715 0.6359
Loa Loa (eye worm) hypothetical protein 0.0339 0.33 0.5433
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2667 0.5638
Plasmodium vivax phosphodiesterase gamma, putative 0.0143 0.1104 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0001 0.0001
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0426 0.427 0.9024
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0426 0.427 0.9024
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.032 0.0622
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0426 0.427 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Toxoplasma gondii hypothetical protein 0.0283 0.2667 0.3916
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0287 0.2715 0.5738
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0143 0.1104 0.1438
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0426 0.427 0.9024
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0426 0.427 1
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2667 0.5638
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.032 0.0526
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0937 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.036 0.3535 0.4605
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.018 0.1518 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Onchocerca volvulus 0.0073 0.032 1
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1104 0.2586
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0426 0.427 0.9024
Loa Loa (eye worm) hypothetical protein 0.0448 0.452 0.7441
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0047 0.0091
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0503 0.5137 0.5137
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 0.2333
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0143 0.1104 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0426 0.427 0.8311
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.032 0.0622
Loa Loa (eye worm) hypothetical protein 0.0073 0.032 0.0526
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0143 0.1104 0.1104
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 1
Echinococcus multilocularis serotonin transporter 0.0073 0.032 0.032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.073 0.7677 0.7677
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0001 0.0002
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0339 0.33 0.5433
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0503 0.5137 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.073 0.7677 0.7677
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0047 0.0091
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0467 0.4731 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0503 0.5137 0.5137
Leishmania major cAMP-specific phosphodiesterase, putative 0.0143 0.1104 0.2586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Leishmania major hypothetical protein, conserved 0.0143 0.1104 0.2586
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0287 0.2715 0.5738
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0143 0.1104 0.1438
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0426 0.427 0.9024
Loa Loa (eye worm) hypothetical protein 0.0587 0.6075 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.073 0.7677 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0143 0.1104 0.2586
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1104 0.2586
Loa Loa (eye worm) hypothetical protein 0.0073 0.032 0.0526
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0339 0.33 0.4299
Plasmodium falciparum phosphodiesterase gamma, putative 0.0143 0.1104 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.036 0.3535 0.5819
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0196 0.1698 0.2796
Loa Loa (eye worm) hypothetical protein 0.0143 0.1104 0.1817
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0143 0.1104 0.1104
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0467 0.4731 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0426 0.427 0.427
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0426 0.427 0.9024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0339 0.33 0.6425
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0143 0.1104 0.1438
Loa Loa (eye worm) hypothetical protein 0.0503 0.5137 0.8456
Plasmodium falciparum phosphodiesterase delta, putative 0.0143 0.1104 1
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1104 0.2586
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 0.2333
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0143 0.1104 0.2149
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0426 0.427 0.9024
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0143 0.1104 0.1104
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0001 0.0001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0143 0.1104 0.2149
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0503 0.5137 0.5137
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.032 0.0416
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0143 0.1104 0.1104
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0143 0.1104 0.2149
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0503 0.5137 0.5137
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1104 0.2586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Leishmania major protein kinase, putative 0.005 0.0066 0.0154
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0426 0.427 0.9024
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.018 0.1518 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 0.2333
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0375 0.3703 0.7208
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0426 0.427 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0143 0.1104 0.2333
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.032 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0426 0.427 0.427
Loa Loa (eye worm) hypothetical protein 0.0196 0.1698 0.2796
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.032 0.0526
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1104 0.2586
Mycobacterium leprae conserved hypothetical protein 0.0139 0.1057 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0146 0.1137 0.0195
Loa Loa (eye worm) hypothetical protein 0.0375 0.3703 0.6095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Leishmania major hypothetical protein, conserved 0.0143 0.1104 0.2586
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0503 0.5137 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0467 0.4731 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0143 0.1104 0.2586
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0282 0.2659 0.5619
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0375 0.3703 0.4823
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1104 0.2586
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.1057 0.2233
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0426 0.427 1
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1104 0.2333
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0282 0.2659 0.5619
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.036 0.3535 0.3535
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0143 0.1104 0.1104
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0044 0 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0426 0.427 0.9024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.1104 0.0115
Loa Loa (eye worm) PDE1B protein 0.0143 0.1104 0.1817
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0426 0.427 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0143 0.1104 0.2333
Trichomonas vaginalis conserved hypothetical protein 0.0467 0.4731 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0426 0.427 0.9024
Loa Loa (eye worm) hypothetical protein 0.0073 0.032 0.0526
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0143 0.1104 0.2333
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1566 0.3309
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0143 0.1104 0.2586
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1104 0.2333
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0143 0.1104 0.2333
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0143 0.1104 0.2149
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0282 0.2659 0.5619

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.4 nM Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cell membranes after 1 hr by scintillation counting analysis ChEMBL. 23253443
IC50 (binding) = 13 nM Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis ChEMBL. 23253443
IC50 (binding) = 7.7 uM Inhibition of human ERG ChEMBL. 23253443

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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