Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Alpha/beta hydrolase family, putative | 0.0127 | 0.0089 | 0.0218 |
Mycobacterium leprae | POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) | 0.0077 | 0 | 0.5 |
Mycobacterium leprae | Probable homoserine o-acetyltransferase MetA | 0.0077 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible haloalkane dehalogenase | 0.0097 | 0.0036 | 0.0037 |
Brugia malayi | hydrolase, alpha/beta fold family protein | 0.0127 | 0.0089 | 0.0218 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2361 | 0.4101 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2361 | 0.4101 | 1 |
Loa Loa (eye worm) | lipase | 0.2361 | 0.4101 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0192 | 0.0467 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0127 | 0.0089 | 0.0091 |
Trypanosoma brucei | Alpha/beta hydrolase family, putative | 0.0127 | 0.0089 | 0.0218 |
Echinococcus multilocularis | abhydrolase domain containing protein 11 | 0.0184 | 0.0192 | 0.0467 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.2361 | 0.4101 | 1 |
Mycobacterium leprae | Probable exported protease | 0.0077 | 0 | 0.5 |
Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0077 | 0 | 0.5 |
Giardia lamblia | ENC6 protein | 0.0077 | 0 | 0.5 |
Brugia malayi | Lipase family protein | 0.2361 | 0.4101 | 1 |
Entamoeba histolytica | alpha/beta hydrolase domain protein, putative | 0.0077 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 0.0036 | 0.0037 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0127 | 0.0089 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.2361 | 0.4101 | 1 |
Onchocerca volvulus | 0.2361 | 0.4101 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0097 | 0.0036 | 0.0037 |
Leishmania major | hypothetical protein, conserved | 0.2361 | 0.4101 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.557 | 0.9862 | 1 |
Plasmodium vivax | alpha/beta hydrolase, putative | 0.0184 | 0.0192 | 1 |
Mycobacterium tuberculosis | Probable haloalkane dehalogenase | 0.0097 | 0.0036 | 0.0037 |
Mycobacterium ulcerans | hydrolase | 0.0127 | 0.0089 | 0.0089 |
Schistosoma mansoni | family S33 non-peptidase homologue (S33 family) | 0.0184 | 0.0192 | 1 |
Echinococcus granulosus | abhydrolase domain containing protein 11 | 0.0184 | 0.0192 | 0.0467 |
Trypanosoma cruzi | Alpha/beta hydrolase family, putative | 0.0127 | 0.0089 | 0.0218 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.0089 | 0.0218 |
Mycobacterium leprae | POSSIBLE SECRETED PROTEASE | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.2361 | 0.4101 | 1 |
Mycobacterium leprae | Probable exported protease | 0.0077 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.2361 | 0.4101 | 1 |
Plasmodium falciparum | alpha/beta hydrolase, putative | 0.0184 | 0.0192 | 1 |
Entamoeba histolytica | alpha/beta hydrolase fold protein, putative | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.2361 | 0.4101 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.2361 | 0.4101 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.