Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast activation protein, alpha | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | Dipeptidyl peptidase 9 | fibroblast activation protein, alpha | 735 aa | 597 aa | 24.5 % |
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0377 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.2718 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.3746 | 0.3746 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.1027 | 0.0784 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.5329 | 0.4794 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0377 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.3746 | 0.632 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.3746 | 0.3149 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0087 | 0.1027 | 0.1027 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.3746 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.1027 | 0.0784 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.1027 | 0.0784 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.3746 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.1027 | 0.0784 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.3746 | 0.632 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3746 | 0.3812 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.5329 | 0.4794 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.5329 | 0.5329 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.3746 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.3746 | 0.303 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0.0796 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.1027 | 0.0784 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 0.5329 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.5329 | 0.5424 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 0.5329 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.3746 | 0.303 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0371 | 0.9825 | 1 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0366 | 0.9659 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0.0796 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 54 nM | Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | ChEMBL. | 23594271 |
IC50 (binding) | = 1800 nM | Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | ChEMBL. | 23594271 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.