Detailed information for compound 1734853

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.475 | Formula: C23H24N6O3
  • H donors: 1 H acceptors: 5 LogP: 2.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cc(ccc1OC)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)n1cncc1
  • InChi: 1S/C23H24N6O3/c1-15-13-32-10-9-29(15)22-18-4-5-19(16-3-6-20(31-2)17(11-16)12-30)25-21(18)26-23(27-22)28-8-7-24-14-28/h3-8,11,14-15,30H,9-10,12-13H2,1-2H3/t15-/m0/s1
  • InChiKey: BMOBPUAXMGRSJZ-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.4072 0.6922
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.3615 0.6145
Brugia malayi hypothetical protein 0.0038 0.3149 0.3149
Brugia malayi Nuclear hormone receptor family member nhr-41 0.008 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.3149 0.3149
Schistosoma mansoni nuclear receptor 0.0038 0.3149 0.3149
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.3149 0.3149
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.008 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.232 0.3945
Onchocerca volvulus Protein ultraspiracle homolog 0.008 1 1
Schistosoma mansoni nuclear hormone receptor 0.008 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.008 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 1 1
Onchocerca volvulus 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1811 0.3078
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.3883 0.3883
Brugia malayi nuclear hormone receptor 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.2969 0.5047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1811 0.3078
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0708 0.1204
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.3883 0.3883
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.3149 0.3149
Brugia malayi Nuclear hormone receptor family member nhr-49 0.008 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.5883 1
Brugia malayi nuclear receptor RXR 0.0042 0.3883 0.3883
Schistosoma mansoni Tr4/Tr2 (homologue) 0.008 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.3149 0.3149
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.2268 0.3855
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.3149 0.3149
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.3149 0.3149
Brugia malayi nuclear receptor NHR-88 0.008 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.4079 0.6934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.008 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.1218 0.207
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.008 1 1
Brugia malayi steroid hormone receptor 0.008 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.4072 0.6922
Brugia malayi Nuclear hormone receptor family member nhr-3 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.3883 0.3883
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.3615 0.6145
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.3615 0.6145
Schistosoma mansoni coup transcription factor 0.008 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.008 1 1
Schistosoma mansoni thyroid hormone receptor 0.008 1 1
Brugia malayi tailless protein 0.0038 0.3149 0.3149
Schistosoma mansoni RAR-like nuclear receptor 0.008 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Echinococcus multilocularis thyroid hormone receptor alpha 0.008 1 1
Brugia malayi nuclear receptor RXR 0.0038 0.3149 0.3149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.008 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.3149 0.3149
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.5883 0.5883
Onchocerca volvulus Bile acid receptor homolog 0.008 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.3149 0.3149
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.3149 0.3149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.008 1 1
Brugia malayi ecdysone receptor 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.4072 0.6922
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.3149 0.3149
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.5883 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.5883 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.3883 0.3883
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.5883 1
Brugia malayi Nuclear hormone receptor E75 0.0038 0.3149 0.3149
Echinococcus multilocularis FTZ F1 alpha 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1811 0.3078
Schistosoma mansoni nuclear hormone receptor 0.0038 0.3149 0.3149
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.5883 0.5883
Brugia malayi Nuclear hormone receptor E75 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.3615 0.6145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1804 0.3066
Echinococcus granulosus FTZ F1 alpha 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.232 0.3945
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.3883 0.3883
Brugia malayi Steroid receptor seven-up type 2 0.008 1 1
Schistosoma mansoni zinc finger protein 0.0038 0.3149 0.3149
Brugia malayi photoreceptor-specific nuclear receptor 0.008 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.3149 0.3149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.008 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.3149 0.3149
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.3883 0.3883
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.008 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.008 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.2268 0.3855
Brugia malayi Nuclear hormone receptor-like 1 0.008 1 1
Brugia malayi hypothetical protein 0.0042 0.3883 0.3883
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.5883 0.5883
Loa Loa (eye worm) hypothetical protein 0.0042 0.3883 0.3883
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.4079 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.3615 0.6145
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.3883 0.3883
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.4589 0.78
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.3149 0.3149
Brugia malayi Nuclear hormone receptor family member nhr-1 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.5883 1
Echinococcus granulosus ecdysone induced protein 78C 0.008 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.008 1 1
Brugia malayi nuclear receptor NHR-67 0.0038 0.3149 0.3149
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Brugia malayi hypothetical protein 0.0042 0.3883 0.3883
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.3615 0.6145
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.5883 1
Loa Loa (eye worm) DR-78 0.0038 0.3149 0.3149
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.5883 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.008 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.3149 0.3149
Brugia malayi conserved hypotetical protein 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1811 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.232 0.3945
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.3149 0.3149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1804 0.3066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1804 0.3066
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.5883 0.5883
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.4072 0.6922
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.008 1 1
Schistosoma mansoni nuclear hormone receptor 0.0038 0.3149 0.3149
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.5883 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.3149 0.3149
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.3149 0.3149
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.4072 0.6922
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.4079 0.6934
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.2778 0.4722
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.3883 0.3883
Brugia malayi nuclear receptor NHR-88 0.0038 0.3149 0.3149
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.3883 0.3883
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Schistosoma mansoni thyroid hormone receptor 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.5883 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.008 1 1
Loa Loa (eye worm) hypothetical protein 0.008 1 1
Giardia lamblia GTOR 0.0054 0.5883 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.008 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.3883 0.3883
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.3615 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.3149 0.3149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 1 1
Brugia malayi nuclear hormone receptor 0.008 1 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.5883 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.5883 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.3883 0.3883
Schistosoma mansoni nuclear receptor 0.0038 0.3149 0.3149
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Loa Loa (eye worm) steroid hormone receptor 0.008 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.3615 0.6145
Schistosoma mansoni retinoic acid receptor RXR 0.008 1 1
Brugia malayi hypothetical protein 0.0038 0.3149 0.3149
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.5883 0.5883
Loa Loa (eye worm) hypothetical protein 0.0038 0.3149 0.3149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.3149 0.3149

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 87 nM BindingDB_Patents: Alternative Enzyme Assay. The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibit phosphorylation by recombinant mTOR.Test compounds were prepared as 10 mM stock solutions in DMSO and diluted into water as required to give a range of final assay concentrations. Aliquots (2 ul) of each compound dilution were placed into a well of a Greiner 384-well low volume (LV) white polystyrene plate (Greiner Bio-one). A 10 ul mixture of recombinant purified mTOR enzyme, 1 uM biotinylated peptide substrate (Biotin-Ahx-Lys-Lys-Ala-Asn-Gln-Val-Phe-Leu-Gly-Phe-Thr-Tyr-Val-Ala-Pro-Ser-Val-Leu-Glu-Ser-Val-Lys-Glu-NH2; Bachem UK Ltd), ATP (20 uM) in a buffer solution [comprising Tris-HCl pH7.4 buffer (50 mM), EGTA (0.1 mM), bovine serum albumin (0.5 mg/ml), DTT (1.25 mM) and manganese chloride (10 mM)] were added to the assay plates and incubated with compound for 2 hours at room temperature. ChEMBL. No reference
IC50 (binding) > 32 uM Inhibition of human ERG ChEMBL. 23375793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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