Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Agaricus bisporus | Tyrosinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Onchocerca volvulus | 0.0806 | 0.1012 | 0.5 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0806 | 0.1012 | 0.03 |
Loa Loa (eye worm) | glutamate receptor | 0.1402 | 0.2364 | 0.2364 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0806 | 0.1012 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1595 | 0.28 | 0.2229 |
Onchocerca volvulus | 0.0806 | 0.1012 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.4771 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0806 | 0.1012 | 0.1012 |
Brugia malayi | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.2007 | 0.3733 | 0.3236 |
Loa Loa (eye worm) | carboxylesterase | 0.0806 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Echinococcus granulosus | acetylcholinesterase | 0.4771 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0806 | 0.1012 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0806 | 0.1012 | 0.1012 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.1727 | 0.3099 | 0.2321 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0806 | 0.1012 | 0.03 |
Schistosoma mansoni | acetylcholinesterase | 0.0806 | 0.1012 | 0.03 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0806 | 0.1012 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.4771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Brugia malayi | Carboxylesterase family protein | 0.4771 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.4771 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0806 | 0.1012 | 0.03 |
Echinococcus granulosus | carboxylesterase 5A | 0.4771 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.4771 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0684 | 0.0735 | 0.0735 |
Onchocerca volvulus | 0.0806 | 0.1012 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0806 | 0.1012 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.1727 | 0.3099 | 0.3099 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.2214 | 0.4203 | 0.3743 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1727 | 0.3099 | 0.2321 |
Echinococcus granulosus | acetylcholinesterase | 0.4771 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0806 | 0.1012 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0806 | 0.1012 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1402 | 0.2364 | 0.2364 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.4771 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1175 | 0.1848 | 0.1202 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0806 | 0.1012 | 0.03 |
Onchocerca volvulus | 0.0806 | 0.1012 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0806 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.4771 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.1175 | 0.1848 | 0.093 |
Brugia malayi | Carboxylesterase family protein | 0.0806 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Brugia malayi | Carboxylesterase family protein | 0.0806 | 0.1012 | 0.1012 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.1271 | 0.2065 | 0.2065 |
Echinococcus multilocularis | acetylcholinesterase | 0.4771 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0806 | 0.1012 | 0.03 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.1175 | 0.1848 | 0.093 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0806 | 0.1012 | 0.5 |
Onchocerca volvulus | 0.0806 | 0.1012 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.4771 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0552 | 0.0436 | 0.0436 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13.1 uM | Inhibition of mushroom tyrosinase assessed as reduction in diphenolase activity using L-DOPA substrate pre-incubated for 20 mins at 30 degC | ChEMBL. | 23391365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.