Detailed information for compound 1734926

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.49 | Formula: C24H29NO6
  • H donors: 1 H acceptors: 3 LogP: 2.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)/C=C/c1cc(OC)c(c2c1C[C@H]1N(C)CC[C@@]32[C@H]1C=C(C(=O)C3)OC)O
  • InChi: 1S/C24H29NO6/c1-5-31-21(27)7-6-14-10-20(30-4)23(28)22-15(14)11-17-16-12-19(29-3)18(26)13-24(16,22)8-9-25(17)2/h6-7,10,12,16-17,28H,5,8-9,11,13H2,1-4H3/b7-6+/t16-,17+,24-/m0/s1
  • InChiKey: OYVWHFRDNREIIJ-APQOQPOSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Variant SH3 domain containing protein 0.1312 0.3898 0.3266
Echinococcus granulosus tensin 0.1312 0.3898 0.5064
Echinococcus multilocularis tyrosine protein kinase csk 0.0883 0.2055 0.267
Trichomonas vaginalis conserved hypothetical protein 0.0883 0.2055 0.5
Toxoplasma gondii protein kinase 0.0883 0.2055 1
Echinococcus granulosus tyrosine kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) TK/CSK protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus raf serine:threonine protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus signal transduction protein lnk realted 0.1312 0.3898 0.5064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1312 0.3898 0.5064
Trypanosoma brucei protein kinase, putative 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2195 0.7697 1
Echinococcus multilocularis FL cytokine receptor 0.0883 0.2055 0.267
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2195 0.7697 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1312 0.3898 0.5064
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis insulin receptor 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.2195 0.7697 1
Trichomonas vaginalis protein kinase atn1, putative 0.0883 0.2055 0.5
Brugia malayi Protein kinase domain containing protein 0.2195 0.7697 1
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Plasmodium vivax tyrosine kinase-like protein, putative 0.0883 0.2055 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis conserved hypothetical protein 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.2195 0.7697 1
Echinococcus multilocularis SH2 motif 0.1312 0.3898 0.5064
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase csk 0.0883 0.2055 0.267
Toxoplasma gondii protein kinase domain-containing protein 0.0883 0.2055 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0883 0.2055 0.267
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Giardia lamblia Kinase, NEK 0.0883 0.2055 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1312 0.3898 0.5064
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Brugia malayi SH2 domain containing protein 0.1312 0.3898 0.3266
Trichomonas vaginalis protein tyrosine kinase, putative 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0883 0.2055 0.267
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0883 0.2055 0.267
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.2195 0.7697 1
Plasmodium falciparum protein kinase, putative 0.0883 0.2055 0.5
Giardia lamblia Protein 21.1 0.0883 0.2055 1
Schistosoma mansoni tyrosine kinase 0.2195 0.7697 0.7697
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Onchocerca volvulus 0.1312 0.3898 0.3266
Trichomonas vaginalis TK family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0883 0.2055 0.267
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Echinococcus multilocularis tyrosine protein kinase 0.0883 0.2055 0.267
Echinococcus multilocularis heat shock protein 70 0.0883 0.2055 0.267
Trichomonas vaginalis conserved hypothetical protein 0.0883 0.2055 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0883 0.2055 0.267
Echinococcus multilocularis natriuretic peptide receptor 1 0.0883 0.2055 0.267
Trypanosoma brucei Pseudokinase, putative 0.0883 0.2055 0.5
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1312 0.3898 0.3898
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Plasmodium falciparum protein kinase, putative 0.0883 0.2055 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1312 0.3898 0.5064
Brugia malayi SH2 domain containing protein 0.2195 0.7697 1
Onchocerca volvulus 0.2195 0.7697 1
Echinococcus multilocularis activin receptor type 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase Blk 0.2195 0.7697 1
Brugia malayi SH2 domain containing protein 0.1312 0.3898 0.3266
Echinococcus granulosus tyrosine protein kinase pr2 0.0883 0.2055 0.267
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0883 0.2055 0.267
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2195 0.7697 1
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Plasmodium falciparum tyrosine kinase-like protein 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Echinococcus granulosus retinal guanylyl cyclase 2 0.0883 0.2055 0.267
Echinococcus multilocularis receptor type guanylyl cyclase 0.0883 0.2055 0.267
Loa Loa (eye worm) STAT protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0883 0.2055 0.267
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0883 0.2055 0.267
Echinococcus granulosus growth factor receptor bound protein 2 0.1312 0.3898 0.5064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1312 0.3898 0.5064
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0883 0.2055 0.267
Giardia lamblia Kinase, NEK 0.0883 0.2055 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1312 0.3898 0.5064
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus expressed conserved protein 0.1312 0.3898 0.5064
Echinococcus multilocularis NCK adaptor protein 0.1312 0.3898 0.5064
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2195 0.7697 1
Echinococcus multilocularis 0.1312 0.3898 0.5064
Schistosoma mansoni tyrosine kinase 0.2195 0.7697 0.7697
Echinococcus multilocularis integrin linked protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase csk 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Echinococcus multilocularis growth factor receptor bound protein 2 0.1312 0.3898 0.5064
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Schistosoma mansoni tyrosine kinase 0.2195 0.7697 0.7697
Loa Loa (eye worm) protein kinase domain-containing protein 0.0883 0.2055 0.267
Onchocerca volvulus 0.1312 0.3898 0.3266
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1312 0.3898 0.5064
Schistosoma mansoni tyrosine protein kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Echinococcus multilocularis SH2 motif 0.1312 0.3898 0.5064
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1312 0.3898 0.5064
Schistosoma mansoni serine/threonine protein kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.2195 0.7697 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0883 0.2055 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus granulosus integrin linked protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1312 0.3898 0.5064
Echinococcus granulosus tyrosine protein kinase Src64B 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni GTPase activating protein 0.1312 0.3898 0.3898
Schistosoma mansoni hypothetical protein 0.1312 0.3898 0.3898
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Schistosoma mansoni ephrin receptor 0.0883 0.2055 0.2055
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1312 0.3898 0.5064
Brugia malayi tRNA modification GTPase TrmE family protein 0.1312 0.3898 0.3266
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Onchocerca volvulus 0.1312 0.3898 0.3266
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2195 0.7697 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0883 0.2055 0.267
Schistosoma mansoni suppressor of cytokine signaling 0.1312 0.3898 0.3898
Schistosoma mansoni SH2A 0.1312 0.3898 0.3898
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0883 0.2055 0.2055
Echinococcus multilocularis protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/ROR protein kinase 0.0883 0.2055 0.267
Echinococcus multilocularis kinase suppressor of Ras 1 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.1312 0.3898 0.3266
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Plasmodium vivax protein kinase, putative 0.0883 0.2055 0.5
Echinococcus granulosus SH2 domain containing protein 7 0.1312 0.3898 0.5064
Echinococcus granulosus SH2 domain containing adapter protein F 0.1312 0.3898 0.5064
Echinococcus multilocularis tyrosine protein kinase csk 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) TK/EGFR protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1312 0.3898 0.5064
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1312 0.3898 0.3898
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis transfer RNA-Thr 0.0883 0.2055 0.267
Loa Loa (eye worm) serine/threonine protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2195 0.7697 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2195 0.7697 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2195 0.7697 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.2195 0.7697 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2195 0.7697 1
Schistosoma mansoni serine/threonine protein kinase 0.0883 0.2055 0.2055
Echinococcus multilocularis tyrosine protein kinase Blk 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus natriuretic peptide receptor 1 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/FER protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/FER protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) SH2 domain-containing protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0883 0.2055 0.267
Toxoplasma gondii STE kinase 0.0883 0.2055 1
Plasmodium falciparum protein kinase, putative 0.0883 0.2055 0.5
Onchocerca volvulus 0.2195 0.7697 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0883 0.2055 0.267
Trichomonas vaginalis AGC family protein kinase 0.0883 0.2055 0.5
Trypanosoma cruzi protein kinase, putative 0.0883 0.2055 0.5
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) TK/EPH protein kinase 0.0883 0.2055 0.267
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1312 0.3898 0.5064
Echinococcus multilocularis epidermal growth factor receptor 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2195 0.7697 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1312 0.3898 0.3898
Echinococcus granulosus kinase suppressor of Ras 1 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Echinococcus multilocularis SHC transforming protein 3 0.1312 0.3898 0.5064
Echinococcus granulosus tyrosine protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/FAK protein kinase 0.0883 0.2055 0.267
Echinococcus multilocularis protein kinase 0.0883 0.2055 0.267
Schistosoma mansoni protein tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus granulosus receptor type guanylyl cyclase 0.0883 0.2055 0.267
Trichomonas vaginalis conserved hypothetical protein 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine kinase 0.2195 0.7697 1
Echinococcus multilocularis c src tyrosine kinase 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus granulosus activated cdc42 kinase 1 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni tyrosine kinase 0.2195 0.7697 0.7697
Loa Loa (eye worm) TK/FER protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.1312 0.3898 0.3898
Schistosoma mansoni hypothetical protein 0.0883 0.2055 0.2055
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase Fyn 0.2195 0.7697 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1312 0.3898 0.5064
Giardia lamblia Kinase 0.0883 0.2055 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Onchocerca volvulus 0.2195 0.7697 1
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus protein tyrosine kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Onchocerca volvulus 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1312 0.3898 0.5064
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1312 0.3898 0.5064
Echinococcus multilocularis signal transduction protein lnk realted 0.1312 0.3898 0.5064
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) RGC/RGC protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Brugia malayi SH2 domain containing protein 0.1312 0.3898 0.3266
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0883 0.2055 0.5
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Echinococcus multilocularis epidermal growth factor receptor 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/ABL protein kinase 0.2195 0.7697 1
Trichomonas vaginalis conserved hypothetical protein 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Schistosoma mansoni tensin 0.1312 0.3898 0.3898
Echinococcus granulosus epidermal growth factor receptor 0.0883 0.2055 0.267
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Brugia malayi protein-tyrosine kinase 0.2195 0.7697 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0883 0.2055 0.267
Trypanosoma brucei Flagellum attachment zone protein 20 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0883 0.2055 0.267
Trichomonas vaginalis CAMK family protein kinase 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Brugia malayi SRC-1 0.2195 0.7697 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.1312 0.3898 0.5064
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1312 0.3898 0.5064
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Echinococcus granulosus N chimaerin 0.1312 0.3898 0.5064
Echinococcus granulosus tyrosine protein kinase HCK 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0883 0.2055 0.2055
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1312 0.3898 0.3898
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.1312 0.3898 0.3898
Onchocerca volvulus 0.2195 0.7697 1
Onchocerca volvulus 0.1312 0.3898 0.3266
Schistosoma mansoni ephrin receptor 0.0883 0.2055 0.2055
Loa Loa (eye worm) TK/ALK protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Brugia malayi Variant SH3 domain containing protein 0.1312 0.3898 0.3266
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni vav2 0.1312 0.3898 0.3898
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Schistosoma mansoni tensin 0.1312 0.3898 0.3898
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0883 0.2055 0.267
Echinococcus granulosus SHC transforming protein 3 0.1312 0.3898 0.5064
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis conserved hypothetical protein 0.0883 0.2055 0.5
Leishmania major protein kinase, putative 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0883 0.2055 0.267
Schistosoma mansoni adapter molecule crk 0.1312 0.3898 0.3898
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Entamoeba histolytica SH2 domain containing protein 0.1312 0.3898 0.3266
Echinococcus granulosus suppressor of cytokine signaling 7 0.1312 0.3898 0.5064
Brugia malayi SH2 domain containing protein 0.1312 0.3898 0.3266
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Echinococcus multilocularis SH2 domain containing protein 7 0.1312 0.3898 0.5064
Brugia malayi Sex muscle abnormal protein 5 0.1312 0.3898 0.3266
Brugia malayi SH2 domain containing protein 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni nck2/grb4 0.1312 0.3898 0.3898
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0883 0.2055 0.267
Brugia malayi SH2 domain containing protein 0.1312 0.3898 0.3266
Brugia malayi RhoGAP domain containing protein 0.1312 0.3898 0.3266
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0883 0.2055 0.5
Loa Loa (eye worm) hypothetical protein 0.2195 0.7697 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/FER protein kinase 0.2195 0.7697 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1312 0.3898 0.5064
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2195 0.7697 0.7697
Schistosoma mansoni hypothetical protein 0.1312 0.3898 0.3898
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1312 0.3898 0.3266
Echinococcus multilocularis tyrosine protein kinase Srms 0.2195 0.7697 1
Brugia malayi Variant SH3 domain containing protein 0.1312 0.3898 0.3266
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus ephrin type A receptor 4 A 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Leishmania major hypothetical protein, conserved 0.0883 0.2055 0.5
Echinococcus granulosus activin receptor type 0.0883 0.2055 0.267
Loa Loa (eye worm) TK/DDR protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0883 0.2055 0.267
Brugia malayi SH2 domain containing protein 0.1312 0.3898 0.3266
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Brugia malayi Protein kinase domain containing protein 0.2195 0.7697 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus SH2 motif 0.1312 0.3898 0.5064
Echinococcus multilocularis tyrosine protein kinase shark 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus granulosus hypothetical protein 0.1312 0.3898 0.5064
Schistosoma mansoni tensin 0.1312 0.3898 0.3898
Schistosoma mansoni serine/threonine protein kinase 0.0883 0.2055 0.2055
Schistosoma mansoni tensin-related 0.1312 0.3898 0.3898
Schistosoma mansoni signal transduction protein lnk-related 0.1312 0.3898 0.3898
Trypanosoma cruzi protein kinase, putative 0.0883 0.2055 0.5
Schistosoma mansoni tyrosine kinase 0.2195 0.7697 0.7697
Echinococcus multilocularis tyrosine kinase 0.2195 0.7697 1
Loa Loa (eye worm) TK/FER protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Brugia malayi hypothetical protein 0.2195 0.7697 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1312 0.3898 0.3898
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus c src tyrosine kinase 0.2195 0.7697 1
Trichomonas vaginalis conserved hypothetical protein 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0883 0.2055 0.267
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0883 0.2055 0.267
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0883 0.2055 1
Schistosoma mansoni serine/threonine protein kinase 0.0883 0.2055 0.2055
Brugia malayi Variant SH3 domain containing protein 0.1312 0.3898 0.3266
Loa Loa (eye worm) TK/ACK protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1312 0.3898 0.5064
Echinococcus granulosus insulin receptor 0.0883 0.2055 0.267
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1312 0.3898 0.3266
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2195 0.7697 1
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Brugia malayi Protein kinase domain containing protein 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus granulosus retinal guanylyl cyclase 2 0.0883 0.2055 0.267
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Onchocerca volvulus 0.1312 0.3898 0.3266
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine kinase 0.0883 0.2055 0.267
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1312 0.3898 0.3266
Schistosoma mansoni shc transforming protein 0.1312 0.3898 0.3898
Loa Loa (eye worm) RGC/RGC protein kinase 0.0883 0.2055 0.267
Brugia malayi Protein kinase domain containing protein 0.2195 0.7697 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0883 0.2055 0.267
Onchocerca volvulus 0.1312 0.3898 0.3266
Echinococcus multilocularis SH2 motif 0.1312 0.3898 0.5064
Echinococcus granulosus NCK adaptor protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) SH2 domain-containing protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Echinococcus multilocularis N chimaerin 0.1312 0.3898 0.5064
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus multilocularis tensin 0.1312 0.3898 0.5064
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2195 0.7697 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0883 0.2055 0.267
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0883 0.2055 0.5
Entamoeba histolytica protein kinase, putative 0.1312 0.3898 0.3266
Brugia malayi hypothetical protein 0.1312 0.3898 0.3266
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0883 0.2055 0.267
Onchocerca volvulus 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0883 0.2055 0.267
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Brugia malayi Protein kinase domain containing protein 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0883 0.2055 0.5
Brugia malayi Tensin 0.1312 0.3898 0.3266
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0883 0.2055 0.267
Echinococcus granulosus protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus activated cdc42 kinase 1 0.0883 0.2055 0.267
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1312 0.3898 0.5064
Echinococcus multilocularis raf serine:threonine protein kinase 0.0883 0.2055 0.267
Trichomonas vaginalis STE family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni protein kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) TK protein kinase 0.2195 0.7697 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1312 0.3898 0.3266
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0883 0.2055 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0883 0.2055 1
Schistosoma mansoni tyrosine kinase 0.2195 0.7697 0.7697
Echinococcus granulosus SH2 motif 0.1312 0.3898 0.5064
Echinococcus multilocularis protein KINase family member (kin 25) 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0883 0.2055 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0883 0.2055 0.267
Schistosoma mansoni serine/threonine RGC 0.0883 0.2055 0.2055
Echinococcus multilocularis protein tyrosine kinase 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine kinase 0.2195 0.7697 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2195 0.7697 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0883 0.2055 0.5
Loa Loa (eye worm) TK protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase shark 0.2195 0.7697 1
Echinococcus multilocularis tensin 0.1312 0.3898 0.5064
Loa Loa (eye worm) hypothetical protein 0.1312 0.3898 0.5064
Loa Loa (eye worm) RGC/RGC protein kinase 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase ABL1 0.2195 0.7697 1
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Echinococcus granulosus epidermal growth factor receptor 0.0883 0.2055 0.267
Leishmania major protein kinase, putative 0.0883 0.2055 0.5
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.1312 0.3898 0.5064
Loa Loa (eye worm) SRC-1 0.2195 0.7697 1
Schistosoma mansoni tensin-related 0.1312 0.3898 0.3898
Brugia malayi cytokine inducible SH2-containing protein 5 0.1312 0.3898 0.3266
Echinococcus granulosus tyrosine protein kinase Fyn 0.2195 0.7697 1
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0883 0.2055 0.2055
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2195 0.7697 1
Brugia malayi SH2 domain containing protein 0.1312 0.3898 0.3266
Schistosoma mansoni tyrosine kinase 0.0883 0.2055 0.2055
Loa Loa (eye worm) RGC/RGC protein kinase 0.0883 0.2055 0.267
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2195 0.7697 1
Schistosoma mansoni suppressor of cytokine signaling 0.1312 0.3898 0.3898
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) hypothetical protein 0.0883 0.2055 0.267
Trichomonas vaginalis TKL family protein kinase 0.0883 0.2055 0.5
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0883 0.2055 0.267

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) > 100 uM Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 24 hrs by MTT assay ChEMBL. 23357309

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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