Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0084 | 0.2066 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0084 | 0.2066 | 0.2066 |
Onchocerca volvulus | 0.0084 | 0.2066 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.0657 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0068 | 0.1212 | 0.5868 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0176 | 0.7064 | 0.7064 |
Loa Loa (eye worm) | cathepsin B | 0.0068 | 0.1212 | 0.0866 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0058 | 0.0657 | 0.093 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0084 | 0.2066 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0068 | 0.1212 | 0.5868 |
Onchocerca volvulus | 0.0084 | 0.2066 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0084 | 0.2066 | 0.2924 |
Loa Loa (eye worm) | fibroinase | 0.0084 | 0.2066 | 0.2198 |
Onchocerca volvulus | Cathepsin F homolog | 0.0084 | 0.2066 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0084 | 0.2066 | 0.2198 |
Brugia malayi | Cathepsin L-like precursor | 0.0084 | 0.2066 | 0.2924 |
Echinococcus multilocularis | cathepsin b | 0.0176 | 0.7064 | 0.7064 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Echinococcus granulosus | cathepsin b | 0.0176 | 0.7064 | 0.7064 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.0657 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.0657 | 0.093 |
Plasmodium vivax | vivapain-2 | 0.0084 | 0.2066 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0084 | 0.2066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.7064 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0058 | 0.0657 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0084 | 0.2066 | 0.0971 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.0657 | 0.093 |
Echinococcus multilocularis | cysteine protease | 0.0084 | 0.2066 | 0.2066 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0084 | 0.2066 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0068 | 0.1212 | 0.1716 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0084 | 0.2066 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.0068 | 0.1212 | 0.5 |
Onchocerca volvulus | 0.0084 | 0.2066 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0084 | 0.2066 | 0.2066 |
Echinococcus granulosus | cathepsin b | 0.0176 | 0.7064 | 0.7064 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0084 | 0.2066 | 0.2924 |
Onchocerca volvulus | Cathepsin L homolog | 0.0084 | 0.2066 | 1 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0084 | 0.2066 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0084 | 0.2066 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0084 | 0.2066 | 0.2924 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0084 | 0.2066 | 0.2066 |
Giardia lamblia | Cathepsin B precursor | 0.0068 | 0.1212 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0058 | 0.0657 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0084 | 0.2066 | 0.2066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0084 | 0.2066 | 1 |
Onchocerca volvulus | 0.0084 | 0.2066 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0084 | 0.2066 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0084 | 0.2066 | 0.2198 |
Onchocerca volvulus | 0.0084 | 0.2066 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0068 | 0.1212 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0084 | 0.2066 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0084 | 0.2066 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0084 | 0.2066 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0084 | 0.2066 | 0.2924 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 0.7064 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0084 | 0.2066 | 0.2066 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0084 | 0.2066 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0084 | 0.2066 | 0.0971 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Plasmodium vivax | vivapain-2 | 0.0084 | 0.2066 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0084 | 0.2066 | 0.2198 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0068 | 0.1212 | 0.1716 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0084 | 0.2066 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0176 | 0.7064 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2066 | 0.2198 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0084 | 0.2066 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.023 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0084 | 0.2066 | 0.2924 |
Echinococcus granulosus | cathepsin l1 | 0.0058 | 0.0657 | 0.0657 |
Onchocerca volvulus | 0.0084 | 0.2066 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0058 | 0.0657 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0084 | 0.2066 | 0.2924 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0176 | 0.7064 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0084 | 0.2066 | 0.2066 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0084 | 0.2066 | 0.2066 |
Onchocerca volvulus | 0.0084 | 0.2066 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0084 | 0.2066 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0084 | 0.2066 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0084 | 0.2066 | 0.2198 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0058 | 0.0657 | 0.093 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 0.7064 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 0.7064 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0176 | 0.7064 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0084 | 0.2066 | 0.2066 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.023 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate at 100 ug/ml preincubated with enzyme for 10 mins prior to substrate addition by Ellman's colorimetric method | ChEMBL. | 23380475 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.