Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | kinase protein | 0.0186 | 0.9825 | 0.9825 |
Mycobacterium ulcerans | hypothetical protein | 0.002 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0057 | 0.2191 | 0.272 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0186 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0057 | 0.2191 | 0.2191 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase | 0.0057 | 0.2191 | 0.2191 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0156 | 0.8052 | 0.8052 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.0156 | 0.8052 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0156 | 0.8052 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0156 | 0.8052 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0156 | 0.8052 | 1 |
Schistosoma mansoni | protein kinase | 0.0156 | 0.8052 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0186 | 0.9825 | 0.9825 |
Brugia malayi | MAP kinase sur-1 | 0.0057 | 0.2191 | 0.2191 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase 7 | 0.0186 | 0.9825 | 0.9825 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0156 | 0.8052 | 0.8052 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0057 | 0.2191 | 0.2191 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.0156 | 0.8052 | 1 |
Echinococcus granulosus | 3'partial|mitogen activated protein kinase kinase kinase | 0.0186 | 0.9825 | 0.9825 |
Echinococcus granulosus | 5'partial|3'partial|mitogen activated protein kinase kinase kinase | 0.0186 | 0.9825 | 0.9825 |
Echinococcus multilocularis | kinase protein | 0.0186 | 0.9825 | 0.9825 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0189 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.0156 | 0.8052 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0057 | 0.2191 | 0.2191 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0186 | 0.9825 | 0.9825 |
Loa Loa (eye worm) | TKL/MLK/TAK1 protein kinase | 0.0189 | 1 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0189 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0156 | 0.8052 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0057 | 0.2191 | 0.5 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0156 | 0.8052 | 0.8052 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0156 | 0.8052 | 0.8052 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0057 | 0.2191 | 0.2191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.