Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0765 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0083 | 0.1045 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0083 | 0.1045 | 1 |
Schistosoma mansoni | protein kinase | 0.0765 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0765 | 1 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0765 | 1 | 0.5 |
Trypanosoma brucei | Forkhead Kinase, putative | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0765 | 1 | 1 |
Leishmania major | serine-threonine protein kinase-like protein | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against extended-spectrum beta-lactamase-producing Escherichia coli isolate 12-2 | ChEMBL. | 23402878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.