Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Fatty acid elongase | ELOVL fatty acid elongase 6 | 265 aa | 259 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0197 | 0.1747 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0137 | 0.0977 | 0.1791 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0197 | 0.1747 | 0.1747 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0487 | 0.5455 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0197 | 0.1747 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0137 | 0.0977 | 0.1791 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0197 | 0.1747 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0197 | 0.1747 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0553 | 0.6292 | 0.6292 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0197 | 0.1747 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0197 | 0.1747 | 0.3202 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0137 | 0.0977 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0487 | 0.5455 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0137 | 0.0977 | 0.1791 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0487 | 0.5455 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0843 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0843 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0843 | 1 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.029 | 0.2938 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0197 | 0.1747 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0487 | 0.5455 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0197 | 0.1747 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0171 | 0.1409 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0977 | 0.5592 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0843 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0487 | 0.5455 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0197 | 0.1747 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0197 | 0.1747 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0137 | 0.0977 | 0.1791 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0843 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0843 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0977 | 0.5592 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0197 | 0.1747 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0197 | 0.1747 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0197 | 0.1747 | 0.1747 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0197 | 0.1747 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1750 nM | Inhibition of human ELOVL6 expressed in Pichia pastoris SND1168 | ChEMBL. | 19522500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.