TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.923 | Formula: C23H24ClN5O
H donors: 0 H acceptors: 3 LogP: 4.46 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC1CCN(CC1)Cc1ccc2c(c1)n1c(nnc1c(n2)C)c1ccccc1Cl
InChi: 1S/C23H24ClN5O/c1-15-22-26-27-23(18-5-3-4-6-19(18)24)29(22)21-13-16(7-8-20(21)25-15)14-28-11-9-17(30-2)10-12-28/h3-8,13,17H,9-12,14H2,1-2H3
InChiKey: UZSLMTQHJNJZLV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 2A, cGMP-stimulated	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	Get druggable targets OG5_135363	All targets in OG5_135363

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	716 aa	26.0 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.2 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.1 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	30.5 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	26.5 %
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	28.9 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	24.1 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	653 aa	23.0 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	30.5 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	699 aa	25.5 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.8 %
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	23.5 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	25.7 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	23.5 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	672 aa	30.2 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	655 aa	24.1 %
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	24.7 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	693 aa	25.3 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	679 aa	26.7 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	phosphodiesterase 2A, cGMP-stimulated	934 aa	748 aa	27.1 %
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	712 aa	25.0 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	683 aa	27.5 %
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	656 aa	30.9 %
Drosophila melanogaster	Phosphodiesterase 6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	684 aa	32.2 %
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	29.0 %
Leishmania donovani	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	688 aa	29.1 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	22.7 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	711 aa	26.2 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.4 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	29.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.086	0.5655	0.5458
Loa Loa (eye worm)	TK/ROR protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0582	0.3576	1
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Brugia malayi	Protein kinase domain containing protein	0.1442	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0582	0.3576	0.2379
Echinococcus multilocularis	SH2 domain containing protein 7	0.086	0.5655	0.4845
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.086	0.5655	0.3235
Echinococcus multilocularis	SH2 motif	0.086	0.5655	0.4845
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0582	0.3576	0.2379
Echinococcus granulosus	tyrosine protein kinase csk	0.0582	0.3576	0.2379
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	SH2 domain containing protein 7	0.086	0.5655	0.4845
Giardia lamblia	Protein 21.1	0.0582	0.3576	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1442	1	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0582	0.3576	0.2379
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.086	0.5655	0.4845
Trichomonas vaginalis	conserved hypothetical protein	0.0582	0.3576	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0582	0.3576	0.2379
Echinococcus granulosus	tyrosine protein kinase Blk	0.1442	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.086	0.5655	0.5458
Echinococcus multilocularis	SHC transforming protein 3	0.086	0.5655	0.4845
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1442	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.086	0.5655	0.4845
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1442	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	SH2 domain containing protein	0.1442	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Schistosoma mansoni	tyrosine kinase	0.1442	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0582	0.3576	0.3285
Schistosoma mansoni	growth factor receptor-bound protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1442	1	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0582	0.3576	0.2379
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.086	0.5655	0.4845
Onchocerca volvulus		0.1442	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.086	0.5655	0.4845
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0582	0.3576	1
Trichomonas vaginalis	conserved hypothetical protein	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	ephrin type A receptor 4 A	0.0582	0.3576	0.2379
Echinococcus multilocularis	tyrosine protein kinase	0.0582	0.3576	0.2379
Plasmodium falciparum	protein kinase, putative	0.0582	0.3576	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0582	0.3576	0.5
Brugia malayi	SH2 domain containing protein	0.086	0.5655	0.5458
Echinococcus granulosus	suppressor of cytokine signaling 7	0.086	0.5655	0.4845
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0582	0.3576	0.3285
Plasmodium falciparum	tyrosine kinase-like protein	0.0582	0.3576	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1442	1	1
Schistosoma mansoni	shc transforming protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	AGC family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	activin receptor type	0.0582	0.3576	0.2379
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0582	0.3576	0.3285
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.1442	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0582	0.3576	0.3285
Giardia lamblia	Kinase, NEK	0.0582	0.3576	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0582	0.3576	0.2379
Schistosoma mansoni	tyrosine kinase	0.1442	1	1
Entamoeba histolytica	SH2 domain containing protein	0.086	0.5655	0.3235
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Brugia malayi	hypothetical protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	protein kinase	0.0582	0.3576	0.2379
Echinococcus granulosus	tyrosine protein kinase Src42A	0.086	0.5655	0.4845
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0582	0.3576	0.3285
Brugia malayi	Protein kinase domain containing protein	0.1442	1	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	insulin receptor	0.0582	0.3576	0.2379
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase csk	0.0582	0.3576	0.2379
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0582	0.3576	0.2379
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0582	0.3576	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0582	0.3576	0.2379
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.086	0.5655	0.5458
Leishmania major	hypothetical protein, conserved	0.0582	0.3576	0.5
Echinococcus granulosus	tyrosine kinase	0.0582	0.3576	0.2379
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0582	0.3576	0.2379
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Brugia malayi	STAT protein, DNA binding domain containing protein	0.086	0.5655	0.5458
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Brugia malayi	integrin-linked kinase	0.0582	0.3576	0.3285
Echinococcus multilocularis	epidermal growth factor receptor	0.0582	0.3576	0.2379
Schistosoma mansoni	adapter molecule crk	0.086	0.5655	0.5458
Onchocerca volvulus		0.1442	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1442	1	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Onchocerca volvulus		0.086	0.5655	0.3235
Loa Loa (eye worm)	TK/EPH protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Trypanosoma brucei	protein kinase, putative	0.0582	0.3576	0.5
Plasmodium falciparum	protein kinase, putative	0.0582	0.3576	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0582	0.3576	0.2379
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Echinococcus multilocularis	NCK adaptor protein	0.086	0.5655	0.4845
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Brugia malayi	C-terminal src kinase protein 1	0.0582	0.3576	0.3285
Echinococcus granulosus	activin receptor type	0.0582	0.3576	0.2379
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.086	0.5655	0.5458
Echinococcus granulosus	suppressor of cytokine signaling 6	0.086	0.5655	0.4845
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1442	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.086	0.5655	0.5458
Echinococcus multilocularis	heat shock protein 70	0.0582	0.3576	0.2379
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.086	0.5655	0.4845
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1442	1	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus granulosus	receptor type guanylyl cyclase	0.0582	0.3576	0.2379
Echinococcus granulosus	integrin linked protein kinase	0.0582	0.3576	0.2379
Schistosoma mansoni	signal transduction protein lnk-related	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	transfer RNA-Thr	0.0582	0.3576	0.2379
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	tensin	0.086	0.5655	0.5458
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.086	0.5655	0.4845
Echinococcus granulosus	insulin receptor	0.0582	0.3576	0.2379
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0582	0.3576	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Brugia malayi	Variant SH3 domain containing protein	0.086	0.5655	0.5458
Echinococcus multilocularis	protein kinase	0.0582	0.3576	0.2379
Echinococcus multilocularis	tyrosine protein kinase csk	0.0582	0.3576	0.2379
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.086	0.5655	0.4845
Brugia malayi	SH2 domain containing protein	0.086	0.5655	0.5458
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.086	0.5655	0.4845
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0582	0.3576	0.5
Schistosoma mansoni	tensin-related	0.086	0.5655	0.5458
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Brugia malayi	hypothetical protein	0.1442	1	1
Trichomonas vaginalis	TK family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK protein kinase	0.1442	1	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0582	0.3576	0.2379
Echinococcus multilocularis	activated cdc42 kinase 1	0.0582	0.3576	0.2379
Schistosoma mansoni	tyrosine protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.086	0.5655	0.5458
Echinococcus granulosus	tyrosine protein kinase Srms	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0582	0.3576	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	tensin	0.086	0.5655	0.4845
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0582	0.3576	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0582	0.3576	0.2379
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0582	0.3576	0.2379
Trichomonas vaginalis	STE family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Brugia malayi	protein-tyrosine kinase	0.1442	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	0.1452	0.1065
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Giardia lamblia	Kinase, NEK	0.0582	0.3576	0.5
Echinococcus multilocularis	SH2 motif	0.086	0.5655	0.4845
Schistosoma mansoni	tyrosine kinase	0.1442	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0582	0.3576	0.2379
Trichomonas vaginalis	conserved hypothetical protein	0.0582	0.3576	1
Schistosoma mansoni	ephrin receptor	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK/FAK protein kinase	0.0582	0.3576	0.3285
Brugia malayi	Raf kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	SH2 domain containing adapter protein F	0.086	0.5655	0.4845
Loa Loa (eye worm)	TK/FER protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	STAT protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Schistosoma mansoni	nck2/grb4	0.086	0.5655	0.5458
Toxoplasma gondii	STE kinase	0.0582	0.3576	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0582	0.3576	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Onchocerca volvulus		0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0582	0.3576	0.3285
Schistosoma mansoni	growth factor receptor-bound protein	0.086	0.5655	0.5458
Brugia malayi	Protein kinase domain containing protein	0.1442	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Brugia malayi	SH2 domain containing protein	0.086	0.5655	0.5458
Brugia malayi	SH2 domain containing protein	0.086	0.5655	0.5458
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0313	0.1571	0.1188
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1442	1	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.086	0.5655	0.5458
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0582	0.3576	0.2379
Echinococcus granulosus	N chimaerin	0.086	0.5655	0.4845
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0582	0.3576	0.2379
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0582	0.3576	0.2379
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0582	0.3576	0.2379
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1442	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0582	0.3576	0.2379
Brugia malayi	Protein kinase domain containing protein	0.1442	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0582	0.3576	0.2379
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0582	0.3576	0.2379
Trichomonas vaginalis	CAMK family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0582	0.3576	0.2379
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0582	0.3576	0.2379
Brugia malayi	SH2 domain containing protein	0.086	0.5655	0.5458
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.086	0.5655	0.3235
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1442	1	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine kinase	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0582	0.3576	0.2379
Loa Loa (eye worm)	TK/FER protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	SRC-1	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Echinococcus granulosus	protein kinase	0.0582	0.3576	0.2379
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.086	0.5655	0.5458
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.086	0.5655	0.4845
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Onchocerca volvulus		0.1442	1	1
Giardia lamblia	Kinase	0.0582	0.3576	0.5
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Onchocerca volvulus		0.086	0.5655	0.3235
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0582	0.3576	0.2379
Echinococcus multilocularis	FL cytokine receptor	0.0582	0.3576	0.2379
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0582	0.3576	0.5
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.1442	1	1
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0582	0.3576	0.2379
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1442	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0582	0.3576	1
Echinococcus granulosus	c src tyrosine kinase	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Schistosoma mansoni	hypothetical protein	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0582	0.3576	0.5
Onchocerca volvulus		0.1442	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0582	0.3576	0.2379
Echinococcus multilocularis	tyrosine kinase	0.0582	0.3576	0.2379
Schistosoma mansoni	hypothetical protein	0.086	0.5655	0.5458
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.086	0.5655	0.5458
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0582	0.3576	0.2379
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	integrin linked protein kinase	0.0582	0.3576	0.2379
Echinococcus multilocularis	SH2 motif	0.086	0.5655	0.4845
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	Tensin	0.086	0.5655	0.5458
Schistosoma mansoni	serine/threonine protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.086	0.5655	0.5458
Echinococcus granulosus	raf serine:threonine protein kinase	0.0582	0.3576	0.2379
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0582	0.3576	0.2379
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.1442	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	suppressor of cytokine signaling	0.086	0.5655	0.5458
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.086	0.5655	0.5458
Onchocerca volvulus		0.086	0.5655	0.3235
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1442	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0582	0.3576	1
Leishmania major	protein kinase, putative	0.0582	0.3576	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.086	0.5655	0.3235
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	hypothetical protein	0.086	0.5655	0.5458
Schistosoma mansoni	tyrosine kinase	0.1442	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Schistosoma mansoni	suppressor of cytokine signaling	0.086	0.5655	0.5458
Brugia malayi	hypothetical protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	tyrosine protein kinase	0.0582	0.3576	0.2379
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0582	0.3576	0.2379
Schistosoma mansoni	protein tyrosine kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Echinococcus multilocularis	growth factor receptor bound protein 2	0.086	0.5655	0.4845
Trichomonas vaginalis	conserved hypothetical protein	0.0582	0.3576	1
Brugia malayi	SH2 domain containing protein	0.1442	1	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0582	0.3576	0.2379
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.086	0.5655	0.4845
Schistosoma mansoni	tensin	0.086	0.5655	0.5458
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.086	0.5655	0.5458
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	vav2	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Toxoplasma gondii	protein kinase	0.0582	0.3576	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	kinase suppressor of Ras 1	0.0582	0.3576	0.2379
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	protein tyrosine kinase	0.0582	0.3576	0.2379
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	serine/threonine protein kinase	0.0582	0.3576	0.3285
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0582	0.3576	0.2379
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0582	0.3576	0.5
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK/FER protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	serine/threonine protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0582	0.3576	0.3285
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0582	0.3576	0.2379
Brugia malayi	hypothetical protein	0.0582	0.3576	0.3285
Echinococcus granulosus	hypothetical protein	0.086	0.5655	0.4845
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	protein tyrosine kinase	0.0582	0.3576	0.2379
Echinococcus multilocularis	tyrosine protein kinase shark	0.1442	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0582	0.3576	0.3285
Leishmania major	protein kinase, putative	0.0582	0.3576	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0582	0.3576	0.3285
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Toxoplasma gondii	protein kinase domain-containing protein	0.0582	0.3576	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0582	0.3576	0.2379
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Onchocerca volvulus		0.086	0.5655	0.3235
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0582	0.3576	0.2379
Trypanosoma cruzi	protein kinase, putative	0.0582	0.3576	0.5
Echinococcus multilocularis	tensin	0.086	0.5655	0.4845
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1442	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0582	0.3576	0.3285
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0582	0.3576	0.2379
Echinococcus granulosus	SH2 motif	0.086	0.5655	0.4845
Loa Loa (eye worm)	TK/FER protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0582	0.3576	0.5
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.086	0.5655	0.4845
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0582	0.3576	0.2379
Brugia malayi	Sex muscle abnormal protein 5	0.086	0.5655	0.5458
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0582	0.3576	0.3285
Onchocerca volvulus		0.086	0.5655	0.3235
Brugia malayi	SH2 domain containing protein	0.086	0.5655	0.5458
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Brugia malayi	Receptor family ligand binding region containing protein	0.0582	0.3576	0.3285
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0582	0.3576	0.2379
Schistosoma mansoni	SH2A	0.086	0.5655	0.5458
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Trichomonas vaginalis	protein kinase atn1, putative	0.0582	0.3576	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus multilocularis	c src tyrosine kinase	0.1442	1	1
Echinococcus granulosus	expressed conserved protein	0.086	0.5655	0.4845
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Brugia malayi	Tyrosine-protein kinase abl-1	0.1442	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.086	0.5655	0.4845
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0582	0.3576	0.2379
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Brugia malayi	ephrin receptor 1 precursor	0.0582	0.3576	0.3285
Brugia malayi	cytokine inducible SH2-containing protein 5	0.086	0.5655	0.5458
Loa Loa (eye worm)	TK/DDR protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0582	0.3576	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.086	0.5655	0.5458
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Plasmodium vivax	protein kinase, putative	0.0582	0.3576	0.5
Echinococcus granulosus	tyrosine kinase	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Schistosoma mansoni	ephrin receptor	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Entamoeba histolytica	protein kinase, putative	0.086	0.5655	0.3235
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine kinase	0.1442	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	SHC transforming protein 3	0.086	0.5655	0.4845
Echinococcus granulosus	NCK adaptor protein	0.086	0.5655	0.4845
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0582	0.3576	0.3285
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0582	0.3576	0.2379
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0582	0.3576	0.2379
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	RhoGAP domain containing protein	0.086	0.5655	0.5458
Schistosoma mansoni	tensin-related	0.086	0.5655	0.5458
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1442	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.086	0.5655	0.5458
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1442	1	1
Echinococcus granulosus	SH2 motif	0.086	0.5655	0.4845
Onchocerca volvulus		0.1442	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0582	0.3576	0.2379
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.086	0.5655	0.4845
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1442	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0582	0.3576	0.2379
Echinococcus granulosus	tyrosine protein kinase Lyn	0.1442	1	1
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	serine/threonine RGC	0.0582	0.3576	0.3285
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	GTPase activating protein	0.086	0.5655	0.5458
Plasmodium falciparum	protein kinase, putative	0.0582	0.3576	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Brugia malayi	Guanylyl cyclase protein 23	0.0582	0.3576	0.3285
Brugia malayi	Variant SH3 domain containing protein	0.086	0.5655	0.5458
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Trypanosoma cruzi	protein kinase, putative	0.0582	0.3576	0.5
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK/Met protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1442	1	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	TK/FER protein kinase	0.1442	1	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein kinase HCK	0.0582	0.3576	0.2379
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Schistosoma mansoni	tyrosine kinase	0.0582	0.3576	0.3285
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trypanosoma brucei	Pseudokinase, putative	0.0582	0.3576	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Onchocerca volvulus		0.086	0.5655	0.3235
Brugia malayi	SRC-1	0.1442	1	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus granulosus	epidermal growth factor receptor	0.0582	0.3576	0.2379
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0582	0.3576	0.3285
Schistosoma mansoni	tensin	0.086	0.5655	0.5458
Echinococcus multilocularis		0.086	0.5655	0.4845
Brugia malayi	Variant SH3 domain containing protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0582	0.3576	1
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Brugia malayi	Variant SH3 domain containing protein	0.086	0.5655	0.5458
Brugia malayi	Protein kinase domain containing protein	0.0582	0.3576	0.3285
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.086	0.5655	0.5458
Loa Loa (eye worm)	TK/INSR protein kinase	0.0582	0.3576	0.3285
Schistosoma mansoni	protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein kinase shark	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.086	0.5655	0.5458
Loa Loa (eye worm)	TK protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	activated cdc42 kinase 1	0.0582	0.3576	0.2379
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1442	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0582	0.3576	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0582	0.3576	0.2379
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0582	0.3576	0.2379
Echinococcus granulosus	tensin	0.086	0.5655	0.4845
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0582	0.3576	0.2379
Echinococcus multilocularis	signal transduction protein lnk realted	0.086	0.5655	0.4845
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.086	0.5655	0.4845
Schistosoma mansoni	serine/threonine protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	growth factor receptor bound protein 2	0.086	0.5655	0.4845
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0582	0.3576	0.3285
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0582	0.3576	0.2379
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0582	0.3576	0.3285
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0582	0.3576	0.2379
Echinococcus granulosus	signal transduction protein lnk realted	0.086	0.5655	0.4845
Loa Loa (eye worm)	hypothetical protein	0.0582	0.3576	0.3285
Brugia malayi	SH2 domain containing protein	0.086	0.5655	0.5458
Trichomonas vaginalis	TKL family protein kinase	0.0582	0.3576	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0582	0.3576	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0256	0.1145	0.0744
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1442	1	1
Echinococcus multilocularis	N chimaerin	0.086	0.5655	0.4845

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 15 nM	Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay	ChEMBL.	23260348
IC50 (binding)	= 39 nM	Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay	ChEMBL.	23260348

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2313241

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1736765