TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.453 | Formula: C23H24FN3O3
H donors: 1 H acceptors: 1 LogP: 4.15 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1N1CCOCC1)Nc1nccc(c1)c1cc(F)ccc1OC
InChi: 1S/C23H24FN3O3/c1-28-21-6-3-17(24)14-19(21)16-7-8-25-23(13-16)26-18-4-5-20(22(15-18)29-2)27-9-11-30-12-10-27/h3-8,13-15H,9-12H2,1-2H3,(H,25,26)
InChiKey: RFZDGPIOKDAECB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TRAF2 and NCK interacting kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Serine/threonine-protein kinase mig-15, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma mansoni	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128641	All targets in OG5_128641
Brugia malayi	probable protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus granulosus	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma mansoni	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus granulosus	serine:threonine protein kinase mig 15	Get druggable targets OG5_128641	All targets in OG5_128641
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	Mitogen-activated protein kinase kinase kinase kinase 4, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus multilocularis		Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	Serine/threonine-protein kinase mig-15, putative	Get druggable targets OG5_128641	All targets in OG5_128641

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	shc transforming protein	0.0149	0.4483	0.4493
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0149	0.4483	0.4493
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine kinase	0.0094	0.1241	0.1241
Echinococcus granulosus	integrin linked protein kinase	0.0094	0.1241	0.1241
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.1241	0.1244
Brugia malayi	SH2 domain containing protein	0.0149	0.4483	0.371
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0149	0.4483	0.4493
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.1241	0.5
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0094	0.1241	0.1244
Echinococcus multilocularis	c src tyrosine kinase	0.0243	0.9978	1
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	hypothetical protein	0.0149	0.4483	0.4483
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0094	0.1241	0.1241
Trypanosoma brucei	protein kinase, putative	0.0094	0.1263	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0243	0.9978	0.9978
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0149	0.4483	0.371
Echinococcus multilocularis	protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	tyrosine protein kinase shark	0.0243	0.9978	0.9978
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0149	0.4483	0.4493
Loa Loa (eye worm)	TK/FER protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/CSK protein kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	tensin	0.0149	0.4483	0.4493
Onchocerca volvulus		0.0149	0.4483	0.371
Echinococcus granulosus	SHC transforming protein 3	0.0149	0.4483	0.4483
Brugia malayi	SH2 domain containing protein	0.0243	0.9978	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0094	0.1241	0.1241
Echinococcus granulosus	receptor type guanylyl cyclase	0.0094	0.1241	0.1241
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0149	0.4483	0.4493
Onchocerca volvulus		0.0243	0.9978	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0243	0.9978	0.9978
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	protein kinase	0.0094	0.1263	0.1266
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Giardia lamblia	Protein 21.1	0.0094	0.1241	0.5
Echinococcus granulosus	expressed conserved protein	0.0149	0.4483	0.4483
Echinococcus multilocularis	tyrosine protein kinase shark	0.0243	0.9978	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0149	0.4505	0.3735
Echinococcus multilocularis	tyrosine kinase	0.0243	0.9978	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0149	0.4483	0.4493
Brugia malayi	SH2 domain containing protein	0.0149	0.4483	0.371
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0149	0.4483	0.4493
Brugia malayi	SRC-1	0.0243	0.9978	1
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0094	0.1241	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0094	0.1241	0.1241
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0094	0.1263	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0094	0.1241	0.1244
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0149	0.4483	0.4493
Loa Loa (eye worm)	TK/FAK protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	SH2 motif	0.0149	0.4483	0.4483
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	insulin receptor	0.0094	0.1241	0.1244
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0149	0.4483	0.4493
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Echinococcus multilocularis	tensin	0.0149	0.4483	0.4493
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0243	0.9978	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Schistosoma mansoni	tensin	0.0149	0.4483	0.4493
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0149	0.4483	0.4483
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0149	0.4483	0.4483
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Brugia malayi	SH2 domain containing protein	0.0149	0.4483	0.371
Brugia malayi	Protein kinase domain containing protein	0.0243	0.9978	1
Brugia malayi	Variant SH3 domain containing protein	0.0149	0.4483	0.371
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0149	0.4483	0.4493
Echinococcus multilocularis	epidermal growth factor receptor	0.0094	0.1241	0.1244
Echinococcus granulosus	protein kinase	0.0094	0.1241	0.1241
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.1241	0.5
Onchocerca volvulus		0.0243	0.9978	1
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0149	0.4483	0.4493
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Brugia malayi	Protein kinase domain containing protein	0.0243	0.9978	1
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Echinococcus multilocularis	heat shock protein 70	0.0094	0.1241	0.1244
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0149	0.4483	0.4493
Schistosoma mansoni	nck2/grb4	0.0149	0.4483	0.4493
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0243	0.9978	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0094	0.1263	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0243	0.9978	0.9978
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	protein tyrosine kinase	0.0094	0.1241	0.1241
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0094	0.1241	0.1244
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0149	0.4483	0.371
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0149	0.4483	0.4483
Schistosoma mansoni	tensin-related	0.0149	0.4483	0.4493
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	ephrin receptor	0.0094	0.1241	0.1244
Brugia malayi	SH2 domain containing protein	0.0149	0.4483	0.371
Schistosoma mansoni	tyrosine kinase	0.0243	0.9978	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0149	0.4483	0.4483
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0094	0.1241	0.1241
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0094	0.1241	0.1244
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0243	0.9978	1
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0149	0.4483	0.4483
Loa Loa (eye worm)	STAT protein	0.0149	0.4483	0.4493
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0149	0.4483	0.4483
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0094	0.1241	0.1244
Echinococcus granulosus	tyrosine protein kinase Srms	0.0243	0.9978	0.9978
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0094	0.1241	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0149	0.4483	0.371
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0094	0.1241	0.1244
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0243	0.9978	0.9978
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0102	0.1755	0.1755
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0094	0.1241	0.1241
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0094	0.1241	0.1244
Plasmodium vivax	protein kinase, putative	0.0094	0.1241	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0243	0.9978	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Schistosoma mansoni	serine/threonine RGC	0.0094	0.1241	0.1244
Echinococcus multilocularis	SH2 domain containing protein 7	0.0149	0.4483	0.4493
Echinococcus granulosus	signal transduction protein lnk realted	0.0149	0.4483	0.4483
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Onchocerca volvulus		0.0243	0.9978	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0243	0.9978	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0149	0.4483	0.4493
Echinococcus granulosus	insulin receptor	0.0094	0.1241	0.1241
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0094	0.1241	0.1241
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0094	0.1241	0.1244
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0094	0.1241	0.1241
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Giardia lamblia	Kinase, NEK	0.0094	0.1241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Trichomonas vaginalis	protein kinase atn1, putative	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0243	0.9978	0.9978
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	ephrin receptor	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	tyrosine kinase	0.0243	0.9978	1
Echinococcus multilocularis	SH2 motif	0.0149	0.4483	0.4493
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0094	0.1241	0.1241
Loa Loa (eye worm)	TK/FER protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0094	0.1241	0.1244
Brugia malayi	Protein kinase domain containing protein	0.0243	0.9978	1
Brugia malayi	hypothetical protein	0.0243	0.9978	1
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0149	0.4483	0.4483
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	growth factor receptor-bound protein	0.0149	0.4483	0.4493
Loa Loa (eye worm)	TK protein kinase	0.0243	0.9978	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0243	0.9978	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Onchocerca volvulus		0.0149	0.4483	0.371
Schistosoma mansoni	tyrosine protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0094	0.1241	0.1241
Echinococcus multilocularis	SH2 motif	0.0149	0.4483	0.4493
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1755	0.1759
Schistosoma mansoni	hypothetical protein	0.0149	0.4483	0.4493
Echinococcus granulosus	raf serine:threonine protein kinase	0.0094	0.1241	0.1241
Loa Loa (eye worm)	TK/ACK protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0094	0.1241	0.1241
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0243	0.9978	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	SH2 motif	0.0149	0.4483	0.4483
Echinococcus multilocularis	tyrosine protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0243	0.9978	1
Brugia malayi	Variant SH3 domain containing protein	0.0149	0.4483	0.371
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0094	0.1241	0.1241
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0094	0.1241	0.5
Echinococcus granulosus	NCK adaptor protein	0.0149	0.4483	0.4483
Echinococcus multilocularis	tyrosine protein kinase csk	0.0094	0.1241	0.1244
Echinococcus multilocularis	tensin	0.0149	0.4483	0.4493
Brugia malayi	Protein kinase domain containing protein	0.0243	0.9978	1
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0243	0.9978	0.9978
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0094	0.1241	0.1241
Loa Loa (eye worm)	TK/FER protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/EPH protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	SH2 domain-containing protein	0.0149	0.4483	0.4493
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0149	0.4483	0.4483
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0149	0.4483	0.371
Loa Loa (eye worm)	TK/FER protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0094	0.1241	0.1244
Echinococcus granulosus	tyrosine kinase	0.0243	0.9978	0.9978
Loa Loa (eye worm)	TK/INSR protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/RYK protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0243	0.9978	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0094	0.1241	0.1241
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0094	0.1263	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0243	0.9978	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	protein tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Entamoeba histolytica	protein kinase, putative	0.0149	0.4505	0.3735
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0243	0.9978	1
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.1241	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0094	0.1263	0.0025
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0094	0.1241	0.1244
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0243	0.9978	1
Brugia malayi	SH2 domain containing protein	0.0149	0.4483	0.371
Schistosoma mansoni	tyrosine kinase	0.0243	0.9978	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Leishmania major	protein kinase, putative	0.0094	0.1263	1
Echinococcus granulosus	epidermal growth factor receptor	0.0094	0.1241	0.1241
Entamoeba histolytica	SH2 domain containing protein	0.0149	0.4483	0.371
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	epidermal growth factor receptor	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/DDR protein kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0243	0.9978	1
Schistosoma mansoni	tyrosine kinase	0.0243	0.9978	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0149	0.4483	0.4493
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0094	0.1241	0.1244
Loa Loa (eye worm)	SH2 domain-containing protein	0.0149	0.4483	0.4493
Echinococcus granulosus	activated cdc42 kinase 1	0.0094	0.1241	0.1241
Schistosoma mansoni	tyrosine kinase	0.0243	0.9978	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0094	0.1241	0.1241
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0243	0.9978	0.9978
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0149	0.4483	0.4493
Echinococcus multilocularis		0.0149	0.4483	0.4493
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0149	0.4483	0.4483
Loa Loa (eye worm)	TK/ROR protein kinase	0.0094	0.1241	0.1244
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0149	0.4483	0.371
Schistosoma mansoni	adapter molecule crk	0.0149	0.4483	0.4493
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0149	0.4483	0.4493
Echinococcus multilocularis	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0094	0.1241	0.1244
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0094	0.1263	1
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0094	0.1241	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0094	0.1241	0.1244
Brugia malayi	Variant SH3 domain containing protein	0.0149	0.4483	0.371
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0243	0.9978	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0094	0.1241	0.1241
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.1241	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0094	0.1241	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0094	0.1241	0.1244
Plasmodium falciparum	protein kinase, putative	0.0094	0.1263	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0149	0.4483	0.371
Echinococcus multilocularis	protein tyrosine kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	tensin	0.0149	0.4483	0.4483
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Brugia malayi	SH2 domain containing protein	0.0149	0.4483	0.371
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0094	0.1241	0.1244
Onchocerca volvulus		0.0149	0.4483	0.371
Loa Loa (eye worm)	TK/FER protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	natriuretic peptide receptor 1	0.0094	0.1241	0.1241
Brugia malayi	SH2 domain containing protein	0.0243	0.9978	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0149	0.4483	0.4493
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	tyrosine kinase	0.0243	0.9978	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0094	0.1241	0.1241
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	GTPase activating protein	0.0149	0.4483	0.4493
Echinococcus granulosus	ephrin type A receptor 4 A	0.0094	0.1241	0.1241
Brugia malayi	Tensin	0.0149	0.4483	0.371
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0094	0.1241	0.1241
Schistosoma mansoni	hypothetical protein	0.0149	0.4483	0.4493
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0243	0.9978	1
Onchocerca volvulus		0.0149	0.4483	0.371
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0243	0.9978	1
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0149	0.4483	0.4493
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	SH2 motif	0.0149	0.4483	0.4493
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.1241	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0149	0.4483	0.4493
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0094	0.1241	0.1241
Echinococcus multilocularis	N chimaerin	0.0149	0.4483	0.4493
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0149	0.4483	0.4493
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus granulosus	activin receptor type	0.0094	0.1263	0.1263
Schistosoma mansoni	protein kinase	0.0094	0.1263	0.1266
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0243	0.9978	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0149	0.4483	0.4493
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/Met protein kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0149	0.4483	0.4493
Echinococcus granulosus	tyrosine kinase	0.0243	0.9978	0.9978
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0243	0.9978	0.9978
Echinococcus granulosus	c src tyrosine kinase	0.0243	0.9978	0.9978
Echinococcus granulosus	tyrosine protein kinase	0.0094	0.1241	0.1241
Schistosoma mansoni	hypothetical protein	0.0094	0.1241	0.1244
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0094	0.1241	0.1244
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.1241	0.1244
Brugia malayi	hypothetical protein	0.0149	0.4483	0.371
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0094	0.1241	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0094	0.1241	0.1241
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0094	0.1241	0.1241
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0243	0.9978	0.9978
Schistosoma mansoni	tensin-related	0.0149	0.4483	0.4493
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Brugia malayi	Protein kinase domain containing protein	0.0243	0.9978	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0094	0.1263	1
Schistosoma mansoni	protein kinase	0.0103	0.1777	0.1781
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0094	0.1241	0.5
Onchocerca volvulus		0.0243	0.9978	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0094	0.1241	0.1244
Echinococcus multilocularis	protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK protein kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	N chimaerin	0.0149	0.4483	0.4483
Onchocerca volvulus		0.0243	0.9978	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Brugia malayi	SH2 domain containing protein	0.0149	0.4483	0.371
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0243	0.9978	0.9978
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0094	0.1263	0.1263
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0243	0.9978	1
Loa Loa (eye worm)	SRC-1	0.0243	0.9978	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0149	0.4483	0.4493
Brugia malayi	protein-tyrosine kinase	0.0243	0.9978	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0094	0.1241	0.1244
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0243	0.9978	0.9978
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0094	0.1241	0.1244
Echinococcus multilocularis	activin receptor type	0.0094	0.1263	0.1266
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0094	0.1241	0.1244
Echinococcus granulosus	growth factor receptor bound protein 2	0.0149	0.4483	0.4483
Schistosoma mansoni	protein kinase	0.0094	0.1263	0.1266
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0243	0.9978	0.9978
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Schistosoma mansoni	SH2A	0.0149	0.4483	0.4493
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0243	0.9978	1
Echinococcus multilocularis	NCK adaptor protein	0.0149	0.4483	0.4493
Brugia malayi	Sex muscle abnormal protein 5	0.0149	0.4483	0.371
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0149	0.4483	0.4493
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0094	0.1241	0.1241
Trichomonas vaginalis	STE family protein kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0094	0.1241	0.1244
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0094	0.1241	0.1241
Schistosoma mansoni	tyrosine kinase	0.0094	0.1241	0.1244
Brugia malayi	RhoGAP domain containing protein	0.0149	0.4483	0.371
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0149	0.4483	0.4493
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0094	0.1241	0.1244
Giardia lamblia	Kinase	0.0094	0.1241	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0149	0.4483	0.4493
Schistosoma mansoni	vav2	0.0149	0.4483	0.4493
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0243	0.9978	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Schistosoma mansoni	tensin	0.0149	0.4483	0.4493
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0149	0.4483	0.371
Echinococcus multilocularis	tyrosine protein kinase csk	0.0094	0.1241	0.1244
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Onchocerca volvulus		0.0243	0.9978	1
Trichomonas vaginalis	TK family protein kinase	0.0094	0.1241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Echinococcus granulosus	kinase suppressor of Ras 1	0.0094	0.1241	0.1241
Brugia malayi	probable protein kinase	0.0103	0.1777	0.0613
Echinococcus multilocularis	transfer RNA-Thr	0.0094	0.1241	0.1244
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0149	0.4483	0.4483
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1241	0.1244
Echinococcus granulosus	activated cdc42 kinase 1	0.0094	0.1241	0.1241
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0094	0.1241	0.1244
Echinococcus multilocularis	FL cytokine receptor	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/FER protein kinase	0.0243	0.9978	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	TK/FER protein kinase	0.0094	0.1241	0.1244
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0149	0.4483	0.4493
Schistosoma mansoni	protein kinase	0.0094	0.1241	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4483	0.4493
Giardia lamblia	Kinase, NEK	0.0094	0.1241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0094	0.1241	0.5
Onchocerca volvulus		0.0149	0.4483	0.371
Onchocerca volvulus		0.0149	0.4483	0.371
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0243	0.9978	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0149	0.4483	0.4493
Echinococcus multilocularis	SHC transforming protein 3	0.0149	0.4483	0.4493

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 118 nM	Inhibition of TNIK (unknown origin) by ADP glo luminescent assay	ChEMBL.	23232060

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2312151

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1736918