Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0124 | 0.1257 | 0.1257 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0248 | 0.0248 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0096 | 0.0845 | 0.0766 |
Brugia malayi | Matrixin family protein | 0.0136 | 0.1423 | 0.1349 |
Onchocerca volvulus | 0.0716 | 1 | 1 | |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0068 | 0.0429 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0068 | 0.0429 | 0.0347 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.0248 | 0.0165 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0096 | 0.0845 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0248 | 0.0248 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0068 | 0.0429 | 0.5 |
Onchocerca volvulus | 0.008 | 0.0594 | 0.0355 | |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0056 | 0.0248 | 0.0248 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0716 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0082 | 0.063 | 0.0582 |
Leishmania major | hypothetical protein, conserved | 0.0716 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0085 | 0.0085 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0716 | 1 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0124 | 0.1257 | 0.1035 |
Loa Loa (eye worm) | AStacin protease | 0.006 | 0.0311 | 0.0311 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0716 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0136 | 0.1423 | 0.1423 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0594 | 0.0544 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0124 | 0.1257 | 0.1035 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0679 | 0.9454 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0204 | 0.2432 | 0.2367 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0787 | 0.0787 |
Loa Loa (eye worm) | lipase | 0.0716 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.0248 | 0.0165 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0096 | 0.0845 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0429 | 0.0429 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0716 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0204 | 0.2432 | 0.2367 |
Trypanosoma brucei | lipase domain protein, putative | 0.0716 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.0248 | 0.0165 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0716 | 1 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0056 | 0.0248 | 0.0174 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.0248 | 0.0165 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0716 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0716 | 1 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.008 | 0.0594 | 0.0514 |
Echinococcus granulosus | Tolloid protein 1 | 0.0096 | 0.0845 | 0.0766 |
Mycobacterium ulcerans | hydrolase | 0.0068 | 0.0429 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0679 | 0.9454 | 0.9449 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0248 | 0.0248 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0679 | 0.9454 | 0.9449 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 13 % | Cytotoxicity against human HepG2 cells assessed as cellular growth at 50 uM incubated for 1 hr prior to TNF alpha stimulation measured after 48 hrs by SRB assay | ChEMBL. | 23219854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.