TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.385 | Formula: C19H18N6O2
H donors: 1 H acceptors: 5 LogP: 2.14 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)c1ccc2c(c1)n1c(nnc1c(n2)C)c1cncc(c1)OC
InChi: 1S/C19H18N6O2/c1-4-21-19(26)12-5-6-15-16(8-12)25-17(11(2)22-15)23-24-18(25)13-7-14(27-3)10-20-9-13/h5-10H,4H2,1-3H3,(H,21,26)
InChiKey: UMJOYABDDYRKPH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 2A, cGMP-stimulated	Starlite/ChEMBL	References
Rattus norvegicus	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	Get druggable targets OG5_135363	All targets in OG5_135363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135549	All targets in OG5_135549

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	712 aa	25.0 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	655 aa	24.1 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	22.7 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	699 aa	25.5 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	30.5 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.8 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	23.5 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	26.5 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.4 %
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	23.5 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	phosphodiesterase 2A, cGMP-stimulated	934 aa	748 aa	27.1 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	679 aa	26.7 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	683 aa	27.5 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	711 aa	26.2 %
Drosophila melanogaster	Phosphodiesterase 6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	684 aa	32.2 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	24.1 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	29.0 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	693 aa	25.3 %
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	24.7 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	29.1 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	25.7 %
Leishmania donovani	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	716 aa	26.0 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.1 %
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	28.9 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	688 aa	29.1 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	30.5 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.2 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	653 aa	23.0 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	672 aa	30.2 %
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	656 aa	30.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Onchocerca volvulus		0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0481	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0285	0.482	0.3133
Schistosoma mansoni	tensin	0.0285	0.482	0.388
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0196	0.2457	0.1089
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0481	1	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0481	1	1
Schistosoma mansoni	tensin	0.0285	0.482	0.388
Leishmania major	hypothetical protein, conserved	0.0196	0.2457	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Echinococcus granulosus	signal transduction protein lnk realted	0.0285	0.482	0.3133
Brugia malayi	Tyrosine-protein kinase PR2	0.0196	0.2457	0.1089
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0285	0.482	0.388
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Echinococcus multilocularis	tensin	0.0285	0.482	0.3133
Brugia malayi	SH2 domain containing protein	0.0481	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0481	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0196	0.2457	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0196	0.2457	1
Schistosoma mansoni	tyrosine protein kinase	0.0196	0.2457	0.1089
Brugia malayi	Tyrosine-protein kinase abl-1	0.0481	1	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0285	0.482	0.3133
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	serine/threonine protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0196	0.2457	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0196	0.2457	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0285	0.482	0.3133
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2457	1
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	SH2 motif	0.0285	0.482	0.3133
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0481	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Toxoplasma gondii	protein kinase	0.0196	0.2457	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0285	0.482	0.3133
Brugia malayi	SH2 domain containing protein	0.0285	0.482	0.388
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	SH2 motif	0.0285	0.482	0.3133
Schistosoma mansoni	suppressor of cytokine signaling	0.0285	0.482	0.388
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2457	1
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2457	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0285	0.482	0.3133
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0481	1	1
Echinococcus multilocularis	N chimaerin	0.0285	0.482	0.3133
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine kinase	0.0481	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0285	0.482	0.3133
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Tensin	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0285	0.482	0.3133
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0196	0.2457	0.5
Echinococcus granulosus	tyrosine kinase	0.0481	1	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0196	0.2457	0.5
Schistosoma mansoni	SH2A	0.0285	0.482	0.388
Loa Loa (eye worm)	TK/DDR protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Trypanosoma cruzi	protein kinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TK family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trypanosoma brucei	protein kinase, putative	0.0196	0.2457	0.5
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Brugia malayi	ephrin receptor 1 precursor	0.0196	0.2457	0.1089
Echinococcus multilocularis	c src tyrosine kinase	0.0481	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0481	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5141	0.4259
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0196	0.2457	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0196	0.2457	0.1089
Brugia malayi	Sex muscle abnormal protein 5	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/ABL protein kinase	0.0481	1	1
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Brugia malayi	hypothetical protein	0.0481	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0481	1	1
Loa Loa (eye worm)	SRC-1	0.0481	1	1
Schistosoma mansoni	tensin	0.0285	0.482	0.388
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine kinase	0.0481	1	1
Onchocerca volvulus		0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0481	1	1
Trichomonas vaginalis	STE family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus multilocularis	NCK adaptor protein	0.0285	0.482	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Giardia lamblia	Kinase, NEK	0.0196	0.2457	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus multilocularis	SHC transforming protein 3	0.0285	0.482	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0481	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0285	0.482	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0481	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0196	0.2457	0.1089
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0285	0.482	0.388
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Brugia malayi	SH2 domain containing protein	0.0285	0.482	0.388
Brugia malayi	Variant SH3 domain containing protein	0.0285	0.482	0.388
Echinococcus granulosus	expressed conserved protein	0.0285	0.482	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Echinococcus multilocularis	SH2 motif	0.0285	0.482	0.3133
Loa Loa (eye worm)	SH2 domain-containing protein	0.0285	0.482	0.388
Giardia lamblia	Kinase	0.0196	0.2457	0.5
Brugia malayi	Protein kinase domain containing protein	0.0481	1	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0313	0.556	0.4754
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0196	0.2457	0.1089
Brugia malayi	SH2 domain containing protein	0.0285	0.482	0.388
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Schistosoma mansoni	serine/threonine protein kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tensin	0.0285	0.482	0.3133
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0196	0.2457	1
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Brugia malayi	hypothetical protein	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0481	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0285	0.482	0.388
Schistosoma mansoni	GTPase activating protein	0.0285	0.482	0.388
Echinococcus granulosus	tyrosine protein kinase Blk	0.0481	1	1
Echinococcus granulosus	NCK adaptor protein	0.0285	0.482	0.3133
Brugia malayi	SH2 domain containing protein	0.0285	0.482	0.388
Echinococcus granulosus	tensin	0.0285	0.482	0.3133
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0196	0.2457	0.5
Onchocerca volvulus		0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Onchocerca volvulus		0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Leishmania major	protein kinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/EPH protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0196	0.2457	0.1089
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0285	0.482	0.388
Loa Loa (eye worm)	TK/FER protein kinase	0.0196	0.2457	0.1089
Brugia malayi	Variant SH3 domain containing protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	hypothetical protein	0.0285	0.482	0.388
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0481	1	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Brugia malayi	SRC-1	0.0481	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0196	0.2457	0.1089
Plasmodium falciparum	protein kinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0285	0.482	0.388
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0481	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0196	0.2457	0.1089
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0481	1	1
Brugia malayi	SH2 domain containing protein	0.0285	0.482	0.388
Brugia malayi	SH2 domain containing protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Raf kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	protein tyrosine kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Onchocerca volvulus		0.0285	0.482	0.3133
Echinococcus multilocularis		0.0285	0.482	0.3133
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0285	0.482	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Brugia malayi	RhoGAP domain containing protein	0.0285	0.482	0.388
Schistosoma mansoni	tensin-related	0.0285	0.482	0.388
Loa Loa (eye worm)	STAT protein	0.0285	0.482	0.388
Echinococcus granulosus	c src tyrosine kinase	0.0481	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2457	1
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0481	1	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0481	1	1
Schistosoma mansoni	nck2/grb4	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0481	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0196	0.2457	0.1089
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0285	0.482	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0285	0.482	0.388
Loa Loa (eye worm)	TK/FER protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/FER protein kinase	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Entamoeba histolytica	protein kinase, putative	0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0196	0.2457	0.1089
Onchocerca volvulus		0.0481	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0285	0.482	0.388
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0196	0.2457	0.1089
Leishmania major	protein kinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0196	0.2457	0.1089
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0285	0.482	0.3133
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0285	0.482	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Schistosoma mansoni	signal transduction protein lnk-related	0.0285	0.482	0.388
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0285	0.482	0.3133
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0313	0.556	0.4114
Onchocerca volvulus		0.0481	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0285	0.482	0.388
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0196	0.2457	0.1089
Onchocerca volvulus		0.0285	0.482	0.3133
Echinococcus granulosus	tyrosine protein kinase shark	0.0481	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0285	0.482	0.3133
Echinococcus multilocularis	tyrosine protein kinase shark	0.0481	1	1
Schistosoma mansoni	hypothetical protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Schistosoma mansoni	hypothetical protein	0.0285	0.482	0.388
Loa Loa (eye worm)	TK/FER protein kinase	0.0196	0.2457	0.1089
Onchocerca volvulus		0.0285	0.482	0.3133
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Brugia malayi	integrin-linked kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0285	0.482	0.3133
Trypanosoma cruzi	protein kinase, putative	0.0196	0.2457	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK protein kinase	0.0481	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Onchocerca volvulus		0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Loa Loa (eye worm)	SH2 domain-containing protein	0.0285	0.482	0.388
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0285	0.482	0.3133
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0285	0.482	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	ephrin receptor	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine kinase	0.0481	1	1
Brugia malayi	SH2 domain containing protein	0.0481	1	1
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0285	0.482	0.3133
Schistosoma mansoni	growth factor receptor-bound protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0196	0.2457	0.5
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	hypothetical protein	0.0481	1	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0481	1	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/INSR protein kinase	0.0196	0.2457	0.1089
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2457	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.4055	0.2977
Schistosoma mansoni	tyrosine kinase	0.0481	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0285	0.482	0.388
Brugia malayi	Guanylyl cyclase protein 23	0.0196	0.2457	0.1089
Echinococcus granulosus	SHC transforming protein 3	0.0285	0.482	0.3133
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0481	1	1
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0285	0.482	0.3133
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0313	0.556	0.4114
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0196	0.2457	0.1089
Schistosoma mansoni	shc transforming protein	0.0285	0.482	0.388
Brugia malayi	protein-tyrosine kinase	0.0481	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0481	1	1
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0196	0.2457	0.1089
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0196	0.2457	0.5
Schistosoma mansoni	ephrin receptor	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Brugia malayi	Variant SH3 domain containing protein	0.0285	0.482	0.388
Schistosoma mansoni	tensin-related	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0481	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK/FER protein kinase	0.0481	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Trypanosoma brucei	Pseudokinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0285	0.482	0.388
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0285	0.482	0.388
Plasmodium vivax	protein kinase, putative	0.0196	0.2457	0.5
Schistosoma mansoni	vav2	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0285	0.482	0.388
Schistosoma mansoni	serine/threonine protein kinase	0.0196	0.2457	0.1089
Onchocerca volvulus		0.0481	1	1
Echinococcus granulosus	SH2 motif	0.0285	0.482	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0481	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0285	0.482	0.3133
Echinococcus granulosus	SH2 domain containing protein 7	0.0285	0.482	0.3133
Echinococcus granulosus	N chimaerin	0.0285	0.482	0.3133
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0481	1	1
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Onchocerca volvulus		0.0481	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0196	0.2457	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Brugia malayi	Protein kinase domain containing protein	0.0481	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0481	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0481	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0196	0.2457	1
Brugia malayi	SH2 domain containing protein	0.0285	0.482	0.388
Loa Loa (eye worm)	TK/ALK protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	C-terminal src kinase protein 1	0.0196	0.2457	0.1089
Echinococcus granulosus	SH2 motif	0.0285	0.482	0.3133
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2457	1
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	SH2 domain containing protein 7	0.0285	0.482	0.3133
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0481	1	1
Schistosoma mansoni	hypothetical protein	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0481	1	1
Echinococcus granulosus	hypothetical protein	0.0285	0.482	0.3133
Giardia lamblia	Kinase, NEK	0.0196	0.2457	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.482	0.388
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0285	0.482	0.3133
Schistosoma mansoni	serine/threonine RGC	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Plasmodium falciparum	protein kinase, putative	0.0196	0.2457	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0196	0.2457	0.1089
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0481	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0196	0.2457	0.1089
Loa Loa (eye worm)	TK protein kinase	0.0196	0.2457	0.1089
Plasmodium falciparum	tyrosine kinase-like protein	0.0196	0.2457	0.5
Brugia malayi	hypothetical protein	0.0196	0.2457	0.1089
Echinococcus granulosus	tyrosine kinase	0.0481	1	1
Plasmodium falciparum	protein kinase, putative	0.0196	0.2457	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	tyrosine kinase	0.0481	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0196	0.2457	1
Toxoplasma gondii	STE kinase	0.0196	0.2457	0.5
Giardia lamblia	Protein 21.1	0.0196	0.2457	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0285	0.482	0.388
Schistosoma mansoni	adapter molecule crk	0.0285	0.482	0.388
Trichomonas vaginalis	TKL family protein kinase	0.0196	0.2457	1
Brugia malayi	Protein kinase domain containing protein	0.0481	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0285	0.482	0.3133
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2457	1
Schistosoma mansoni	protein kinase	0.0196	0.2457	0.1089

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.9 nM	Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay	ChEMBL.	23260348
IC50 (binding)	= 50 nM	Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay	ChEMBL.	23260348

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2313257

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1737503