Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0085 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0147 | 0.1941 | 1 |
Echinococcus granulosus | jun protein | 0.009 | 0.0964 | 0.4965 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0085 | 0.0085 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.009 | 0.0964 | 0.4965 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0085 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0147 | 0.1941 | 0.1941 |
Toxoplasma gondii | hypothetical protein | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0073 | 0.0676 | 0.3482 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0085 | 0.0439 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0085 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.1941 | 1 |
Echinococcus multilocularis | jun protein | 0.009 | 0.0964 | 0.4965 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0267 | 0.3996 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0922 | 0.0922 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0147 | 0.1941 | 0.1941 |
Onchocerca volvulus | 0.0071 | 0.0634 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0085 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0619 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0634 | 0.0634 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0676 | 0.3482 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0085 | 0.5 |
Leishmania major | squalene monooxygenase-like protein | 0.0267 | 0.3996 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0085 | 0.0439 |
Echinococcus granulosus | carbonic anhydrase II | 0.0147 | 0.1941 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0267 | 0.3996 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.1941 | 1 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0267 | 0.3996 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0147 | 0.1941 | 0.1941 |
Brugia malayi | bZIP transcription factor family protein | 0.009 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0147 | 0.1941 | 0.1941 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0085 | 0.0439 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.009 | 0.0964 | 0.4965 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 5 nM | Inhibitory activity against human carbonic anhydrase II using pH stat assay | ChEMBL. | 1920359 |
IC50 (functional) | = 5 nM | Inhibitory activity against human carbonic anhydrase II using pH stat assay | ChEMBL. | 1920359 |
logD (ADMET) | = 1.47 | Partition coefficient (logD7.4) | ChEMBL. | 1920359 |
pKa | = 8.05 | Dissociation constant (pKa) (determined in 30% EtOH/water) | ChEMBL. | 1920359 |
S | = 0.92 mg ml-1 | Solubility (buffer pH 7.4) | ChEMBL. | 1920359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.