Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-myristoyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 0.403423 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0215982 | 0.403423 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 0.403423 | 0.5 |
Echinococcus granulosus | neuroglian | 0.00389751 | 0.037433 | 0.0428724 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 0.403423 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 0.403423 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0215982 | 0.403423 | 0.390601 |
Giardia lamblia | CDC72 | 0.0215982 | 0.403423 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0504511 | 1 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.00310464 | 0.0210393 | 0.0521521 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0504511 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.00490965 | 0.0583605 | 0.0976015 |
Schistosoma mansoni | nephrin | 0.00389751 | 0.037433 | 0.0927886 |
Loa Loa (eye worm) | hypothetical protein | 0.00490965 | 0.0583605 | 0.0381233 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0471272 | 0.931273 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.00411678 | 0.0419668 | 0.104027 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0215982 | 0.403423 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00490965 | 0.0583605 | 0.0381233 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0215982 | 0.403423 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00411678 | 0.0419668 | 0.0213772 |
Echinococcus multilocularis | neuroglian | 0.00389751 | 0.037433 | 0.0428724 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 0.403423 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 0.403423 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.00490965 | 0.0583605 | 0.0976015 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.00310464 | 0.0210393 | 0.0521521 |
Schistosoma mansoni | N-myristoyltransferase | 0.0215982 | 0.403423 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.00411678 | 0.0419668 | 0.0547291 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0215982 | 0.403423 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.00310464 | 0.0210393 | 0.0521521 |
Leishmania major | N-myristoyl transferase, putative | 0.0215982 | 0.403423 | 0.5 |
Brugia malayi | N-myristoyltransferase 2 | 0.0215982 | 0.403423 | 0.390601 |
Echinococcus granulosus | twitchin | 0.00389751 | 0.037433 | 0.0428724 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2 uM | Antiplasmodium activity against Chloroquine-sensitive later trophozoite form of Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by FACS flow cytometric analysis | ChEMBL. | 23170970 |
Inhibition (binding) | Inhibition of human NMT2 | ChEMBL. | 23170970 | |
Ki (binding) | = 3.2 uM | Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay | ChEMBL. | 23170970 |
Ki (binding) | = 3.2 uM | Binding affinity to human N-myristoyltransferase by fluorescence analysis | ChEMBL. | 26962429 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 23170970 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.