Detailed information for compound 1738579

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 656.812 | Formula: C41H44N4O4
  • H donors: 2 H acceptors: 4 LogP: 6.36 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@@H]1CCCN1C(=O)Cc1ccccc1)Nc1ccc(cc1)C(c1ccc(cc1)NC(=O)[C@@H]1CCCN1C(=O)Cc1ccccc1)(C)C
  • InChi: 1S/C41H44N4O4/c1-41(2,31-17-21-33(22-18-31)42-39(48)35-15-9-25-44(35)37(46)27-29-11-5-3-6-12-29)32-19-23-34(24-20-32)43-40(49)36-16-10-26-45(36)38(47)28-30-13-7-4-8-14-30/h3-8,11-14,17-24,35-36H,9-10,15-16,25-28H2,1-2H3,(H,42,48)(H,43,49)/t35-,36-/m0/s1
  • InChiKey: STJMYSKNZOIHRT-ZPGRZCPFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0456 0.5413 0.2402
Brugia malayi Protein kinase domain containing protein 0.0802 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.083 0.083
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.0853 0.0853
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0802 1 1
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Brugia malayi protein-tyrosine kinase 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0456 0.5413 1
Onchocerca volvulus 0.0456 0.5413 0.2402
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0346 0.3963 0.3963
Loa Loa (eye worm) TK/RYK protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0802 1 1
Plasmodium falciparum protein kinase, putative 0.0456 0.5413 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0802 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0456 0.5413 0.5
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Brugia malayi Receptor family ligand binding region containing protein 0.0456 0.5413 0.5413
Echinococcus granulosus expressed conserved protein 0.0103 0.0742 0.0742
Echinococcus granulosus insulin receptor 0.0456 0.5413 0.5413
Brugia malayi integrin-linked kinase 0.0456 0.5413 0.5413
Schistosoma mansoni shc transforming protein 0.0346 0.3963 0.3963
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0456 0.5413 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.5413 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0456 0.5413 0.5
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis SH2 domain containing protein 7 0.0346 0.3963 0.3963
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0346 0.3963 0.3963
Echinococcus multilocularis expressed conserved protein 0.0103 0.0742 0.0742
Echinococcus granulosus activated cdc42 kinase 1 0.0456 0.5413 0.5413
Echinococcus multilocularis growth factor receptor bound protein 2 0.0346 0.3963 0.3963
Echinococcus granulosus integrin linked protein kinase 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Echinococcus granulosus protein tyrosine kinase 0.0456 0.5413 0.5413
Echinococcus granulosus suppressor of cytokine signaling 6 0.0346 0.3963 0.3963
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0346 0.3963 0.3963
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Brugia malayi STAT protein, DNA binding domain containing protein 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0346 0.3963 0.3963
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0456 0.5413 0.5413
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Fyn 0.0802 1 1
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Loa Loa (eye worm) SH2 domain-containing protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis tyrosine protein kinase 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Entamoeba histolytica serine/threonine kinase, putative 0.0456 0.5413 0.4998
Brugia malayi Guanylyl cyclase protein 23 0.0456 0.5413 0.5413
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase csk 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Brugia malayi SRC-1 0.0802 1 1
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Schistosoma mansoni tensin-related 0.0346 0.3963 0.3963
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0802 1 1
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tensin-related 0.0346 0.3963 0.3963
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0346 0.3963 0.3963
Brugia malayi Protein kinase domain containing protein 0.0802 1 1
Brugia malayi SH2 domain containing protein 0.0346 0.3963 0.3963
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) hypothetical protein 0.011 0.083 0.083
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0456 0.5413 0.5413
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Entamoeba histolytica serine/threonine kinase, putative 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Onchocerca volvulus 0.0456 0.5413 0.2402
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0802 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0456 0.5413 0.5413
Loa Loa (eye worm) protein kinase domain-containing protein 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Lyn 0.0802 1 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0346 0.3963 0.3963
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis FL cytokine receptor 0.0456 0.5413 0.5413
Trichomonas vaginalis AGC family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0456 0.5413 0.5413
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0456 0.5413 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Brugia malayi tRNA modification GTPase TrmE family protein 0.0346 0.3963 0.3963
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK/EGFR protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/FER protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0802 1 1
Brugia malayi hypothetical protein 0.0802 1 1
Echinococcus granulosus tyrosine kinase 0.0802 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0456 0.5413 0.4998
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0456 0.5413 0.5413
Trichomonas vaginalis protein tyrosine kinase, putative 0.0456 0.5413 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica cysteine surface protein, putative 0.0456 0.5413 0.4998
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Toxoplasma gondii protein kinase domain-containing protein 0.0456 0.5413 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0802 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.5413 1
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Brugia malayi SH2 domain containing protein 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Echinococcus granulosus tyrosine protein kinase pr2 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) serine/threonine protein kinase 0.0456 0.5413 0.5413
Echinococcus granulosus c src tyrosine kinase 0.0802 1 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0456 0.5413 0.5413
Onchocerca volvulus 0.0456 0.5413 0.2402
Schistosoma mansoni vav2 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica serine/threonine kinase, putative 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0802 1 1
Schistosoma mansoni tyrosine kinase 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.5413 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis epidermal growth factor receptor 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis heat shock protein 70 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Brugia malayi Protein kinase domain containing protein 0.0802 1 1
Brugia malayi Protein kinase domain containing protein 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0802 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0802 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Giardia lamblia Kinase, NEK 0.0456 0.5413 0.5
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Brugia malayi Variant SH3 domain containing protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK/FER protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0456 0.5413 1
Echinococcus multilocularis SH2 motif 0.0346 0.3963 0.3963
Onchocerca volvulus 0.0456 0.5413 0.2402
Schistosoma mansoni tensin 0.0346 0.3963 0.3963
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0456 0.5413 0.2402
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Brugia malayi SH2 domain containing protein 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0802 1 1
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0346 0.3963 0.3963
Leishmania major protein kinase, putative 0.0456 0.5413 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0346 0.3963 0.3963
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Trypanosoma brucei Flagellum attachment zone protein 20 0.0456 0.5413 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Schistosoma mansoni ephrin receptor 0.0456 0.5413 0.5413
Toxoplasma gondii STE kinase 0.0456 0.5413 0.5
Loa Loa (eye worm) hypothetical protein 0.0166 0.1582 0.1582
Onchocerca volvulus 0.0456 0.5413 0.2402
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0456 0.5413 0.5413
Brugia malayi hypothetical protein 0.0456 0.5413 0.5413
Trypanosoma brucei Pseudokinase, putative 0.0456 0.5413 0.5
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Brugia malayi Raf kinase 0.0456 0.5413 0.5413
Brugia malayi hypothetical protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/INSR protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Onchocerca volvulus 0.0802 1 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0802 1 1
Brugia malayi Sex muscle abnormal protein 5 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus tyrosine protein kinase 0.0456 0.5413 0.5413
Plasmodium falciparum tyrosine kinase-like protein 0.0456 0.5413 0.5
Echinococcus granulosus activin receptor type 0.0456 0.5413 0.5413
Brugia malayi C-terminal src kinase protein 1 0.0456 0.5413 0.5413
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0456 0.5413 1
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0346 0.3963 0.3963
Echinococcus granulosus hypothetical protein 0.0346 0.3963 0.3963
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase Srms 0.0802 1 1
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.083 0.083
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni nck2/grb4 0.0346 0.3963 0.3963
Loa Loa (eye worm) SRC-1 0.0802 1 1
Plasmodium falciparum protein kinase, putative 0.0456 0.5413 0.5
Echinococcus granulosus tyrosine kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0456 0.5413 0.5413
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0802 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK/FER protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Entamoeba histolytica ankyrin repeat protein 0.0456 0.5413 0.4998
Schistosoma mansoni growth factor receptor-bound protein 0.0346 0.3963 0.3963
Echinococcus granulosus N chimaerin 0.0346 0.3963 0.3963
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0802 1 1
Echinococcus granulosus tyrosine protein kinase shark 0.0802 1 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0346 0.3963 0.3963
Echinococcus granulosus retinal guanylyl cyclase 2 0.0456 0.5413 0.5413
Echinococcus granulosus ephrin type A receptor 4 A 0.0456 0.5413 0.5413
Onchocerca volvulus 0.0802 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0456 0.5413 0.5
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0456 0.5413 0.5413
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0456 0.5413 0.5
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0456 0.5413 0.5413
Echinococcus multilocularis SH2 motif 0.0346 0.3963 0.3963
Schistosoma mansoni SH2A 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis protein kinase atn1, putative 0.0456 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Brugia malayi Variant SH3 domain containing protein 0.0346 0.3963 0.3963
Echinococcus granulosus retinal guanylyl cyclase 2 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Echinococcus granulosus raf serine:threonine protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0802 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.1454 0.1454
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.5413 1
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica tyrosin kinase, putative 0.0456 0.5413 0.4998
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0456 0.5413 0.5413
Echinococcus multilocularis activin receptor type 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0346 0.3963 0.3963
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0346 0.3963 0.3963
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Brugia malayi SH2 domain containing protein 0.0346 0.3963 0.3963
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0346 0.3963 0.3963
Echinococcus granulosus tyrosine kinase 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0346 0.3963 0.3963
Echinococcus granulosus tyrosine protein kinase Src42A 0.0346 0.3963 0.3963
Entamoeba histolytica receptor protein kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0456 0.5413 0.5413
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0456 0.5413 0.2402
Echinococcus multilocularis tensin 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis SHC transforming protein 3 0.0346 0.3963 0.3963
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0802 1 1
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Fyn 0.0802 1 1
Trypanosoma brucei protein kinase, putative 0.0456 0.5413 0.5
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Schistosoma mansoni adapter molecule crk 0.0346 0.3963 0.3963
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0456 0.5413 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0456 0.5413 0.5413
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica hypothetical protein, conserved 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Trypanosoma cruzi protein kinase, putative 0.0456 0.5413 0.5
Onchocerca volvulus 0.0802 1 1
Echinococcus multilocularis c src tyrosine kinase 0.0802 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0346 0.3963 0.3416
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0802 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0802 1 1
Onchocerca volvulus 0.0456 0.5413 0.2402
Loa Loa (eye worm) hypothetical protein 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Loa Loa (eye worm) TK/FER protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis protein KINase family member (kin 25) 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Blk 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Trichomonas vaginalis TK family protein kinase 0.0456 0.5413 1
Echinococcus granulosus SH2 motif 0.0346 0.3963 0.3963
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase csk 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0456 0.5413 0.5413
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Echinococcus multilocularis N chimaerin 0.0346 0.3963 0.3963
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Leishmania major hypothetical protein, conserved 0.0456 0.5413 0.5
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0346 0.3963 0.3963
Schistosoma mansoni serine/threonine protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica tyrosin kinase, putative 0.0456 0.5413 0.4998
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0456 0.5413 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0456 0.5413 0.5413
Plasmodium vivax tyrosine kinase-like protein, putative 0.0456 0.5413 0.5
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Brugia malayi Immunoglobulin I-set domain containing protein 0.0456 0.5413 0.5413
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0802 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0802 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0456 0.5413 0.5413
Echinococcus granulosus signal transduction protein lnk realted 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Echinococcus granulosus tyrosine protein kinase csk 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Trypanosoma cruzi protein kinase, putative 0.0456 0.5413 0.5
Brugia malayi Muscleblind-like protein 0.0166 0.1582 0.1582
Echinococcus multilocularis tyrosine kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0456 0.5413 0.5413
Entamoeba histolytica SH2 domain containing protein 0.0346 0.3963 0.3416
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni protein tyrosine kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) SH2 domain-containing protein 0.0346 0.3963 0.3963
Echinococcus granulosus tensin 0.0346 0.3963 0.3963
Brugia malayi Variant SH3 domain containing protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) TK/FER protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni hypothetical protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) TK/FER protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Onchocerca volvulus 0.0802 1 1
Brugia malayi SH2 domain containing protein 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Brugia malayi bone morphogenetic protein type 1 receptor 0.0456 0.5413 0.5413
Echinococcus multilocularis protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica receptor protein kinase, putative 0.0456 0.5413 0.4998
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0456 0.5413 0.5413
Echinococcus multilocularis muscleblind protein 1 0.0166 0.1582 0.1582
Brugia malayi hypothetical protein 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Srms 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Echinococcus multilocularis protein dispatched 1 0.0054 0.0088 0.0088
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0456 0.5413 0.5413
Schistosoma mansoni tensin 0.0346 0.3963 0.3963
Loa Loa (eye worm) TK/FER protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase csk 0.0456 0.5413 0.5413
Brugia malayi Variant SH3 domain containing protein 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0346 0.3963 0.3416
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0456 0.5413 0.5413
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Onchocerca volvulus 0.0456 0.5413 0.2402
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0346 0.3963 0.3963
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0802 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Giardia lamblia Kinase, NEK 0.0456 0.5413 0.5
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0802 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Onchocerca volvulus Tyrosine kinase homolog 0.0456 0.5413 0.2402
Entamoeba histolytica ankyrin repeat protein 0.0456 0.5413 0.4998
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Echinococcus granulosus activated cdc42 kinase 1 0.0456 0.5413 0.5413
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Brugia malayi SH2 domain containing protein 0.0346 0.3963 0.3963
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni hypothetical protein 0.0456 0.5413 0.5413
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Src64B 0.0802 1 1
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica serine/threonine kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) hypothetical protein 0.0058 0.014 0.014
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0456 0.5413 0.5413
Echinococcus granulosus SH2 motif 0.0346 0.3963 0.3963
Toxoplasma gondii protein kinase 0.0456 0.5413 0.5
Echinococcus granulosus muscleblind protein 0.0166 0.1582 0.1582
Brugia malayi ephrin receptor 1 precursor 0.0456 0.5413 0.5413
Brugia malayi SH2 domain containing protein 0.0346 0.3963 0.3963
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis transfer RNA-Thr 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Echinococcus multilocularis muscleblind protein 0.0166 0.1582 0.1582
Echinococcus multilocularis 0.0346 0.3963 0.3963
Echinococcus multilocularis integrin linked protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/FER protein kinase 0.0802 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Onchocerca volvulus 0.0456 0.5413 0.2402
Loa Loa (eye worm) RGC/RGC protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Echinococcus multilocularis tyrosine protein kinase HCK 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni signal transduction protein lnk-related 0.0346 0.3963 0.3963
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0456 0.5413 0.4998
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK protein kinase 0.0802 1 1
Onchocerca volvulus 0.0802 1 1
Trichomonas vaginalis STE family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Schistosoma mansoni hypothetical protein 0.0346 0.3963 0.3963
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Plasmodium falciparum protein kinase, putative 0.0456 0.5413 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase pr2 0.0456 0.5413 0.5413
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.5413 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0456 0.5413 0.5413
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0456 0.5413 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Schistosoma mansoni serine/threonine protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.5413 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0346 0.3963 0.3963
Plasmodium vivax protein kinase, putative 0.0456 0.5413 0.5
Loa Loa (eye worm) TK/ALK protein kinase 0.0456 0.5413 0.5413
Echinococcus granulosus protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/Met protein kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) STAT protein 0.0346 0.3963 0.3963
Schistosoma mansoni growth factor receptor-bound protein 0.0346 0.3963 0.3963
Loa Loa (eye worm) RGC/RGC protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0456 0.5413 0.5413
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0456 0.5413 0.5413
Echinococcus multilocularis ephrin type A receptor 4 A 0.0456 0.5413 0.5413
Echinococcus multilocularis natriuretic peptide receptor 1 0.0456 0.5413 0.5413
Schistosoma mansoni ephrin receptor 0.0456 0.5413 0.5413
Entamoeba histolytica tyrosin kinase, putative 0.0456 0.5413 0.4998
Echinococcus multilocularis tensin 0.0346 0.3963 0.3963
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus granulosus SHC transforming protein 3 0.0346 0.3963 0.3963
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Schistosoma mansoni protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0802 1 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Echinococcus granulosus suppressor of cytokine signaling 7 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK/FAK protein kinase 0.0456 0.5413 0.5413
Brugia malayi RhoGAP domain containing protein 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Brugia malayi cytokine inducible SH2-containing protein 5 0.0346 0.3963 0.3963
Brugia malayi SH2 domain containing protein 0.0802 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni serine/threonine RGC 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Schistosoma mansoni serine/threonine protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.5413 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0346 0.3963 0.3963
Brugia malayi Furin-like cysteine rich region family protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) hypothetical protein 0.0346 0.3963 0.3963
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0456 0.5413 0.5413
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0456 0.5413 0.5413
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/ACK protein kinase 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase csk 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Schistosoma mansoni tensin 0.0346 0.3963 0.3963
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0346 0.3963 0.3963
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis insulin receptor 0.0456 0.5413 0.5413
Schistosoma mansoni GTPase activating protein 0.0346 0.3963 0.3963
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Leishmania major protein kinase, putative 0.0456 0.5413 0.5
Echinococcus multilocularis NCK adaptor protein 0.0346 0.3963 0.3963
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Brugia malayi Tyrosine-protein kinase PR2 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Echinococcus multilocularis SH2 motif 0.0346 0.3963 0.3963
Brugia malayi SH2 domain containing protein 0.0802 1 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0456 0.5413 0.4998
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0802 1 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0456 0.5413 0.5413
Brugia malayi Tensin 0.0346 0.3963 0.3963
Loa Loa (eye worm) hypothetical protein 0.0456 0.5413 0.5413
Echinococcus granulosus SH2 domain containing protein 7 0.0346 0.3963 0.3963
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Giardia lamblia Protein 21.1 0.0456 0.5413 0.5
Loa Loa (eye worm) TK/CSK protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni tyrosine kinase 0.0456 0.5413 0.5413
Loa Loa (eye worm) SH2 domain-containing protein 0.0346 0.3963 0.3963
Echinococcus granulosus SH2 domain containing adapter protein F 0.0346 0.3963 0.3963
Echinococcus multilocularis protein tyrosine kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0346 0.3963 0.3963
Echinococcus granulosus receptor type guanylyl cyclase 0.0456 0.5413 0.5413
Echinococcus granulosus growth factor receptor bound protein 2 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK/ROR protein kinase 0.0456 0.5413 0.5413
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0456 0.5413 0.5413
Echinococcus granulosus expressed conserved protein 0.0346 0.3963 0.3963
Echinococcus multilocularis tyrosine kinase 0.0802 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0802 1 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0456 0.5413 0.5413
Echinococcus multilocularis signal transduction protein lnk realted 0.0346 0.3963 0.3963
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Echinococcus multilocularis protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0802 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0456 0.5413 0.5413
Giardia lamblia Kinase 0.0456 0.5413 0.5
Echinococcus granulosus natriuretic peptide receptor 1 0.0456 0.5413 0.5413
Schistosoma mansoni suppressor of cytokine signaling 0.0346 0.3963 0.3963
Trichomonas vaginalis TKL family protein kinase 0.0456 0.5413 1
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.5413 0.4998
Echinococcus granulosus NCK adaptor protein 0.0346 0.3963 0.3963
Entamoeba histolytica hypothetical protein 0.0456 0.5413 0.4998
Loa Loa (eye worm) TK/DDR protein kinase 0.0456 0.5413 0.5413
Schistosoma mansoni suppressor of cytokine signaling 0.0346 0.3963 0.3963
Loa Loa (eye worm) hypothetical protein 0.0166 0.1582 0.1582
Echinococcus granulosus fibroblast growth factor receptor 4 0.0456 0.5413 0.5413
Echinococcus granulosus tyrosine protein kinase Src42A 0.0802 1 1
Loa Loa (eye worm) TK protein kinase 0.0456 0.5413 0.5413
Trichomonas vaginalis CAMK family protein kinase 0.0456 0.5413 1
Brugia malayi Protein kinase domain containing protein 0.0456 0.5413 0.5413
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.1454 0.1454
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0456 0.5413 0.4998
Entamoeba histolytica protein kinase, putative 0.0456 0.5413 0.4998
Echinococcus granulosus epidermal growth factor receptor 0.0456 0.5413 0.5413
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0456 0.5413 0.5413
Echinococcus multilocularis tyrosine protein kinase Abl 0.0802 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.0456 0.5413 0.5
Onchocerca volvulus 0.0802 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0456 0.5413 0.4998
Loa Loa (eye worm) RGC/RGC protein kinase 0.0456 0.5413 0.5413

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 10000 nM Cytotoxicity against human HuH7 cells after 72 hrs by Alamar blue assay ChEMBL. 23273521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.