Detailed information for compound 1738598

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.406 | Formula: C16H18N4S
  • H donors: 1 H acceptors: 1 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)/C(=N\NC(=S)N(C)C)/c1ccccn1
  • InChi: 1S/C16H18N4S/c1-12-7-9-13(10-8-12)15(14-6-4-5-11-17-14)18-19-16(21)20(2)3/h4-11H,1-3H3,(H,19,21)/b18-15+
  • InChiKey: MDJKBVJPDYIMIU-OBGWFSINSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.1876 1 1
Entamoeba histolytica ankyrin repeat protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus tyrosine protein kinase csk 0.1074 0.5403 0.5338
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis serine-threonine protein kinase, putative 0.1074 0.5403 0.5
Onchocerca volvulus 0.1074 0.5403 0.5403
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus granulosus hypothetical protein 0.0802 0.3842 0.3756
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0802 0.3842 0.3842
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica serine/threonine kinase, putative 0.1074 0.5403 0.2534
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Loa Loa (eye worm) RGC/RGC protein kinase 0.1074 0.5403 0.5403
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1074 0.5403 0.5403
Echinococcus granulosus NCK adaptor protein 0.0802 0.3842 0.3756
Schistosoma mansoni tensin-related 0.0802 0.3842 0.3842
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus granulosus N chimaerin 0.0802 0.3842 0.3756
Schistosoma mansoni GTPase activating protein 0.0802 0.3842 0.3842
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Brugia malayi Protein kinase domain containing protein 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus tyrosine kinase 0.1876 1 1
Loa Loa (eye worm) plexin A 0.0156 0.0138 0.0138
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0802 0.3842 0.3756
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus multilocularis tensin 0.0802 0.3842 0.3756
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni shc transforming protein 0.0802 0.3842 0.3842
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus granulosus suppressor of cytokine signaling 6 0.0802 0.3842 0.3756
Echinococcus multilocularis 0.0802 0.3842 0.3756
Brugia malayi hypothetical protein 0.1876 1 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1074 0.5403 0.5338
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.1074 0.5403 0.5338
Giardia lamblia Kinase 0.1074 0.5403 0.5
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis growth factor receptor bound protein 2 0.0802 0.3842 0.3756
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni serine/threonine protein kinase 0.1074 0.5403 0.5403
Entamoeba histolytica ankyrin repeat protein 0.1074 0.5403 0.2534
Brugia malayi Sex muscle abnormal protein 5 0.0802 0.3842 0.3842
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0802 0.3842 0.3842
Schistosoma mansoni protein tyrosine kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni src-type protein tyrosine kinase-related 0.1074 0.5403 0.5403
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0802 0.3842 0.3842
Echinococcus multilocularis retinal guanylyl cyclase 2 0.1074 0.5403 0.5338
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0802 0.3842 0.3842
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Brugia malayi C-terminal src kinase protein 1 0.1074 0.5403 0.5403
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.1074 0.5403 0.5338
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus SHC transforming protein 3 0.0802 0.3842 0.3756
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Leishmania major hypothetical protein, conserved 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus c src tyrosine kinase 0.1876 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0802 0.3842 0.3756
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.1074 0.5403 0.5338
Echinococcus granulosus tyrosine kinase 0.1074 0.5403 0.5338
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0802 0.3842 0.3756
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0802 0.3842 0.3842
Loa Loa (eye worm) RGC/RGC protein kinase 0.1074 0.5403 0.5403
Brugia malayi hypothetical protein 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/FER protein kinase 0.1074 0.5403 0.5403
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0802 0.3842 0.3842
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus tyrosine protein kinase pr2 0.1074 0.5403 0.5338
Entamoeba histolytica serine/threonine kinase, putative 0.1074 0.5403 0.2534
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0802 0.3842 0.3842
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Brugia malayi SH2 domain containing protein 0.0802 0.3842 0.3842
Brugia malayi Probable tyrosine-protein kinase kin-31 0.1074 0.5403 0.5403
Schistosoma mansoni tensin-related 0.0802 0.3842 0.3842
Toxoplasma gondii protein kinase domain-containing protein 0.1074 0.5403 0.5
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.1074 0.5403 0.5403
Brugia malayi Probable tyrosine-protein kinase kin-31 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis c src tyrosine kinase 0.1876 1 1
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/ACK protein kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.1074 0.5403 0.5403
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK protein kinase 0.1876 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Trichomonas vaginalis TK family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Brugia malayi cytokine inducible SH2-containing protein 5 0.0802 0.3842 0.3842
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1876 1 1
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Toxoplasma gondii protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0802 0.3842 0.3756
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Onchocerca volvulus 0.0802 0.3842 0.3842
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1876 1 1
Schistosoma mansoni signal transduction protein lnk-related 0.0802 0.3842 0.3842
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Plasmodium falciparum tyrosine kinase-like protein 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus retinal guanylyl cyclase 2 0.1074 0.5403 0.5338
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Plasmodium falciparum protein kinase, putative 0.1074 0.5403 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.5403 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.1074 0.5403 0.5338
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine-protein kinase fps85d 0.1074 0.5403 0.5403
Giardia lamblia Kinase, NEK 0.1074 0.5403 0.5
Onchocerca volvulus 0.1074 0.5403 0.5403
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0802 0.3842 0.3756
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus raf serine:threonine protein kinase 0.1074 0.5403 0.5338
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.1074 0.5403 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1074 0.5403 0.5338
Echinococcus granulosus natriuretic peptide receptor 1 0.1074 0.5403 0.5338
Echinococcus granulosus retinal guanylyl cyclase 2 0.1074 0.5403 0.5338
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Schistosoma mansoni hypothetical protein 0.0802 0.3842 0.3842
Entamoeba histolytica tyrosin kinase, putative 0.1074 0.5403 0.2534
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0802 0.3842 0.3756
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1876 1 1
Brugia malayi Variant SH3 domain containing protein 0.0802 0.3842 0.3842
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.1876 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Echinococcus multilocularis receptor type guanylyl cyclase 0.1074 0.5403 0.5338
Brugia malayi SRC-1 0.1876 1 1
Loa Loa (eye worm) TK/Met protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis SH2 motif 0.0802 0.3842 0.3756
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Echinococcus multilocularis protein kinase 0.1074 0.5403 0.5338
Toxoplasma gondii STE kinase 0.1074 0.5403 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1876 1 1
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus suppressor of cytokine signaling 7 0.0802 0.3842 0.3756
Echinococcus multilocularis SH2 motif 0.0802 0.3842 0.3756
Onchocerca volvulus 0.1074 0.5403 0.5403
Brugia malayi Immunoglobulin I-set domain containing protein 0.1074 0.5403 0.5403
Giardia lamblia Protein 21.1 0.1074 0.5403 0.5
Trypanosoma brucei Pseudokinase, putative 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) TK/ROR protein kinase 0.1074 0.5403 0.5403
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.1074 0.5403 0.2534
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1074 0.5403 0.5338
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0802 0.3842 0.3842
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis protein kinase atn1, putative 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0802 0.3842 0.3842
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.5403 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1074 0.5403 0.5338
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0802 0.3842 0.3842
Plasmodium falciparum tyrosine kinase-like protein 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/FER protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0802 0.3842 0.3842
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi Variant SH3 domain containing protein 0.0802 0.3842 0.3842
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Brugia malayi Protein kinase domain containing protein 0.1876 1 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.1074 0.5403 0.5338
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1074 0.5403 0.5403
Entamoeba histolytica serine/threonine kinase, putative 0.1074 0.5403 0.2534
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase shark 0.1876 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0802 0.3842 0.3756
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.1876 1 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1876 1 1
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Trypanosoma brucei Flagellum attachment zone protein 20 0.1074 0.5403 0.5
Onchocerca volvulus 0.1876 1 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus tyrosine protein kinase Src42A 0.1876 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Plasmodium vivax tyrosine kinase-like protein, putative 0.1074 0.5403 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.1074 0.5403 0.5338
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1074 0.5403 0.5338
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Schistosoma mansoni suppressor of cytokine signaling 0.0802 0.3842 0.3842
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0802 0.3842 0.3756
Echinococcus granulosus growth factor receptor bound protein 2 0.0802 0.3842 0.3756
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Entamoeba histolytica tyrosin kinase, putative 0.1098 0.5541 0.2758
Brugia malayi Immunoglobulin I-set domain containing protein 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.1876 1 1
Loa Loa (eye worm) TK/FAK protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis SH2 domain containing protein 7 0.0802 0.3842 0.3756
Brugia malayi Guanylyl cyclase protein 23 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Entamoeba histolytica hypothetical protein, conserved 0.1074 0.5403 0.2534
Brugia malayi tRNA modification GTPase TrmE family protein 0.0802 0.3842 0.3842
Echinococcus granulosus tyrosine protein kinase csk 0.1074 0.5403 0.5338
Schistosoma mansoni adapter molecule crk 0.0802 0.3842 0.3842
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Echinococcus granulosus SH2 domain containing adapter protein F 0.0802 0.3842 0.3756
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni tyrosine kinase 0.1876 1 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.1074 0.5403 0.5338
Loa Loa (eye worm) SH2 domain-containing protein 0.0802 0.3842 0.3842
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/CSK protein kinase 0.1074 0.5403 0.5403
Echinococcus granulosus signal transduction protein lnk realted 0.0802 0.3842 0.3756
Brugia malayi hypothetical protein 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase Fyn 0.1876 1 1
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus multilocularis protein tyrosine kinase 0.1074 0.5403 0.5338
Schistosoma mansoni tensin 0.0802 0.3842 0.3842
Plasmodium vivax protein kinase, putative 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica tyrosin kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi Raf kinase 0.1074 0.5403 0.5403
Echinococcus granulosus expressed conserved protein 0.0802 0.3842 0.3756
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Schistosoma mansoni hypothetical protein 0.0802 0.3842 0.3842
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0802 0.3842 0.3756
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis CAMK family protein kinase 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) SH2 domain-containing protein 0.0802 0.3842 0.3842
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0802 0.3842 0.3756
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Echinococcus multilocularis tyrosine kinase 0.1074 0.5403 0.5338
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Onchocerca volvulus 0.0802 0.3842 0.3842
Echinococcus multilocularis tyrosine protein kinase csk 0.1074 0.5403 0.5338
Schistosoma mansoni tyrosine-protein kinase fps85d 0.1074 0.5403 0.5403
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.1074 0.5403 0.5338
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.1074 0.5403 0.5338
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1876 1 1
Onchocerca volvulus 0.0802 0.3842 0.3842
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase HCK 0.1074 0.5403 0.5338
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.1074 0.5403 0.5403
Schistosoma mansoni ephrin receptor 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni serine/threonine protein kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.1074 0.5403 0.5338
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi SH2 domain containing protein 0.0802 0.3842 0.3842
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Loa Loa (eye worm) TK/DDR protein kinase 0.1074 0.5403 0.5403
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1876 1 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.1074 0.5403 0.5338
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.1074 0.5403 0.5338
Brugia malayi Tyrosine-protein kinase PR2 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.1074 0.5403 0.5338
Echinococcus multilocularis retinal guanylyl cyclase 2 0.1074 0.5403 0.5338
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0802 0.3842 0.3756
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni tensin 0.0802 0.3842 0.3842
Loa Loa (eye worm) serine/threonine protein kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1876 1 1
Loa Loa (eye worm) TK/INSR protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis activin receptor type 0.1074 0.5403 0.5338
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Entamoeba histolytica receptor protein kinase, putative 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1876 1 1
Brugia malayi plexin A 0.0156 0.0138 0.0138
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni tyrosine kinase 0.1876 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1074 0.5403 0.5403
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Brugia malayi Tensin 0.0802 0.3842 0.3842
Brugia malayi SH2 domain containing protein 0.1876 1 1
Onchocerca volvulus 0.0802 0.3842 0.3842
Loa Loa (eye worm) TK/KIN6 protein kinase 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1074 0.5403 0.5338
Entamoeba histolytica cysteine surface protein, putative 0.1074 0.5403 0.2534
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Schistosoma mansoni serine/threonine protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0802 0.3842 0.3842
Echinococcus granulosus tyrosine protein kinase Lyn 0.1876 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis signal transduction protein lnk realted 0.0802 0.3842 0.3756
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1074 0.5403 0.5338
Echinococcus multilocularis tyrosine protein kinase shark 0.1876 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.1074 0.5403 0.5338
Leishmania major protein kinase, putative 0.1074 0.5403 0.5
Echinococcus granulosus SH2 motif 0.0802 0.3842 0.3756
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1876 1 1
Loa Loa (eye worm) SRC-1 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine kinase 0.1876 1 1
Echinococcus multilocularis SH2 motif 0.0802 0.3842 0.3756
Echinococcus multilocularis natriuretic peptide receptor 1 0.1074 0.5403 0.5338
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/ALK protein kinase 0.1074 0.5403 0.5403
Echinococcus granulosus receptor type guanylyl cyclase 0.1074 0.5403 0.5338
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi Protein kinase domain containing protein 0.1876 1 1
Plasmodium falciparum protein kinase, putative 0.1074 0.5403 0.5
Trichomonas vaginalis protein tyrosine kinase, putative 0.1074 0.5403 0.5
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni suppressor of cytokine signaling 0.0802 0.3842 0.3842
Echinococcus multilocularis kinase suppressor of Ras 1 0.1074 0.5403 0.5338
Echinococcus multilocularis ephrin type A receptor 4 A 0.1074 0.5403 0.5338
Echinococcus granulosus activated cdc42 kinase 1 0.1074 0.5403 0.5338
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis tyrosine protein kinase 0.1074 0.5403 0.5338
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus multilocularis integrin linked protein kinase 0.1074 0.5403 0.5338
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase Src64B 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase Blk 0.1876 1 1
Brugia malayi SH2 domain containing protein 0.0802 0.3842 0.3842
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.1074 0.5403 0.2534
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Onchocerca volvulus 0.1074 0.5403 0.5403
Echinococcus granulosus fibroblast growth factor receptor 4 0.1074 0.5403 0.5338
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0802 0.3842 0.3842
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus granulosus dual specificity testis-specific protein kinase 0.1074 0.5403 0.5338
Echinococcus granulosus protein kinase 0.1074 0.5403 0.5338
Echinococcus multilocularis transfer RNA-Thr 0.1074 0.5403 0.5338
Trypanosoma brucei protein kinase, putative 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni hypothetical protein 0.1074 0.5403 0.5403
Echinococcus multilocularis tyrosine kinase 0.1876 1 1
Brugia malayi hypothetical protein 0.0802 0.3842 0.3842
Schistosoma mansoni tensin 0.0802 0.3842 0.3842
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1074 0.5403 0.5338
Trypanosoma cruzi protein kinase, putative 0.1074 0.5403 0.5
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.1074 0.5403 0.5
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.1074 0.5403 0.5338
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Brugia malayi SH2 domain containing protein 0.1876 1 1
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Leishmania major protein kinase, putative 0.1074 0.5403 0.5
Onchocerca volvulus 0.1876 1 1
Schistosoma mansoni vav2 0.0802 0.3842 0.3842
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.1074 0.5403 0.5403
Brugia malayi integrin-linked kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis NCK adaptor protein 0.0802 0.3842 0.3756
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Loa Loa (eye worm) SH2 domain-containing protein 0.0802 0.3842 0.3842
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Echinococcus multilocularis epidermal growth factor receptor 0.1074 0.5403 0.5338
Echinococcus multilocularis FL cytokine receptor 0.1074 0.5403 0.5338
Schistosoma mansoni tyrosine kinase 0.1876 1 1
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis N chimaerin 0.0802 0.3842 0.3756
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Brugia malayi Receptor family ligand binding region containing protein 0.1074 0.5403 0.5403
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.5403 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1074 0.5403 0.5338
Brugia malayi Furin-like cysteine rich region family protein 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Echinococcus multilocularis dual specificity testis specific protein kinase 0.1074 0.5403 0.5338
Schistosoma mansoni ephrin receptor 0.1074 0.5403 0.5403
Brugia malayi RhoGAP domain containing protein 0.0802 0.3842 0.3842
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.1074 0.5403 0.5403
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Entamoeba histolytica protein kinase domain containing protein 0.1098 0.5541 0.2758
Brugia malayi SH2 domain containing protein 0.0802 0.3842 0.3842
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase Src42A 0.0802 0.3842 0.3756
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0802 0.3842 0.3756
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.1074 0.5403 0.5338
Onchocerca volvulus 0.0802 0.3842 0.3842
Brugia malayi bone morphogenetic protein type 1 receptor 0.1074 0.5403 0.5403
Trichomonas vaginalis AGC family protein kinase 0.1074 0.5403 0.5
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Entamoeba histolytica receptor protein kinase, putative 0.1074 0.5403 0.2534
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Onchocerca volvulus 0.1074 0.5403 0.5403
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.1074 0.5403 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0802 0.3842 0.3756
Echinococcus granulosus epidermal growth factor receptor 0.1074 0.5403 0.5338
Onchocerca volvulus 0.1876 1 1
Echinococcus multilocularis insulin receptor 0.1074 0.5403 0.5338
Plasmodium falciparum protein kinase, putative 0.1074 0.5403 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.1074 0.5403 0.5338
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus activin receptor type 0.1074 0.5403 0.5338
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1074 0.5403 0.2534
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Loa Loa (eye worm) STAT protein 0.0802 0.3842 0.3842
Onchocerca volvulus 0.1876 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus integrin linked protein kinase 0.1074 0.5403 0.5338
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1876 1 1
Onchocerca volvulus 0.1074 0.5403 0.5403
Echinococcus multilocularis heat shock protein 70 0.1074 0.5403 0.5338
Onchocerca volvulus Tyrosine kinase homolog 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine protein kinase 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/FER protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/EGFR protein kinase 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0802 0.3842 0.3842
Brugia malayi ephrin receptor 1 precursor 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.1876 1 1
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Echinococcus granulosus tyrosine protein kinase 0.1074 0.5403 0.5338
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.1074 0.5403 0.5338
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.1074 0.5403 0.5338
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1876 1 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0802 0.3842 0.3842
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1876 1 1
Brugia malayi SH2 domain containing protein 0.0802 0.3842 0.3842
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1876 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.1074 0.5403 0.5403
Echinococcus multilocularis tyrosine protein kinase Blk 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Brugia malayi Variant SH3 domain containing protein 0.0802 0.3842 0.3842
Brugia malayi Variant SH3 domain containing protein 0.0802 0.3842 0.3842
Loa Loa (eye worm) hypothetical protein 0.0802 0.3842 0.3842
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus multilocularis tyrosine protein kinase csk 0.1074 0.5403 0.5338
Echinococcus multilocularis SHC transforming protein 3 0.0802 0.3842 0.3756
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/FER protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.1876 1 1
Schistosoma mansoni serine/threonine RGC 0.1074 0.5403 0.5403
Schistosoma mansoni growth factor receptor-bound protein 0.0802 0.3842 0.3842
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Onchocerca volvulus 0.1074 0.5403 0.5403
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1074 0.5403 0.5338
Brugia malayi SH2 domain containing protein 0.0802 0.3842 0.3842
Plasmodium vivax tyrosine kinase-like protein, putative 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.1074 0.5403 0.5338
Echinococcus granulosus SH2 motif 0.0802 0.3842 0.3756
Onchocerca volvulus 0.0802 0.3842 0.3842
Entamoeba histolytica protein kinase domain containing protein 0.1074 0.5403 0.2534
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1876 1 1
Echinococcus granulosus kinase suppressor of Ras 1 0.1074 0.5403 0.5338
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0802 0.3842 0.3756
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus epidermal growth factor receptor 0.1074 0.5403 0.5338
Brugia malayi SH2 domain containing protein 0.0802 0.3842 0.3842
Loa Loa (eye worm) protein kinase domain-containing protein 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine protein kinase csk 0.1074 0.5403 0.5338
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1876 1 1
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Echinococcus granulosus tensin 0.0802 0.3842 0.3756
Echinococcus multilocularis tyrosine protein kinase Abl 0.1876 1 1
Schistosoma mansoni nck2/grb4 0.0802 0.3842 0.3842
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Schistosoma mansoni protein kinase 0.1074 0.5403 0.5403
Schistosoma mansoni tyrosine kinase 0.1074 0.5403 0.5403
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Echinococcus multilocularis tensin 0.0802 0.3842 0.3756
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.1074 0.5403 0.5338
Trichomonas vaginalis STE family protein kinase 0.1074 0.5403 0.5
Echinococcus multilocularis protein KINase family member (kin 25) 0.1074 0.5403 0.5338
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Entamoeba histolytica tyrosin kinase, putative 0.1074 0.5403 0.2534
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403
Entamoeba histolytica serine/threonine kinase, putative 0.1074 0.5403 0.2534
Echinococcus granulosus protein tyrosine kinase 0.1074 0.5403 0.5338
Onchocerca volvulus 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Giardia lamblia Kinase, NEK 0.1074 0.5403 0.5
Onchocerca volvulus 0.1074 0.5403 0.5403
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Entamoeba histolytica hypothetical protein 0.1074 0.5403 0.2534
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Echinococcus granulosus insulin receptor 0.1074 0.5403 0.5338
Schistosoma mansoni tyrosine kinase 0.1876 1 1
Brugia malayi Protein kinase domain containing protein 0.1074 0.5403 0.5403
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0802 0.3842 0.3842
Schistosoma mansoni tyrosine kinase 0.1876 1 1
Trichomonas vaginalis TKL family protein kinase 0.1074 0.5403 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.1074 0.5403 0.5403
Onchocerca volvulus 0.1074 0.5403 0.5403
Onchocerca volvulus 0.1876 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1074 0.5403 0.5338
Entamoeba histolytica tyrosine kinase, putative 0.1074 0.5403 0.2534
Echinococcus multilocularis tyrosine protein kinase HCK 0.1074 0.5403 0.5338
Trypanosoma cruzi protein kinase, putative 0.1074 0.5403 0.5
Entamoeba histolytica protein kinase, putative 0.1074 0.5403 0.2534
Brugia malayi protein-tyrosine kinase 0.1876 1 1
Schistosoma mansoni SH2A 0.0802 0.3842 0.3842
Echinococcus granulosus SH2 domain containing protein 7 0.0802 0.3842 0.3756
Schistosoma mansoni serine/threonine protein kinase 0.1074 0.5403 0.5403
Loa Loa (eye worm) hypothetical protein 0.1074 0.5403 0.5403
Echinococcus granulosus tyrosine kinase 0.1876 1 1
Echinococcus multilocularis protein kinase 0.1074 0.5403 0.5338
Loa Loa (eye worm) TK protein kinase 0.1074 0.5403 0.5403

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 8 % Reduction of cellular 59Fe uptake from 59Fe-Transferrin in human SK-N-MC cells assessed as 59Fe level prelabeled with 59Fe2-Tf at 25 uM after 3 hrs relative to control ChEMBL. 23276209
IC50 (ADMET) = 0.921 uM Cytotoxicity against human MRC5 cells assessed as growth inhibition after 72 hrs by MTT assay ChEMBL. 23276209

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23276209

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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