Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | valosin containing protein | 0.034 | 0.4627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.4627 | 1 |
Plasmodium vivax | cell division cycle ATPase, putative | 0.021 | 0.1711 | 0.1834 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.058 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.024 | 0.238 | 0.238 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.055 | 0.9331 | 0.9331 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.058 | 1 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.034 | 0.4627 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0347 | 0.4783 | 1 |
Loa Loa (eye worm) | VCP protein | 0.024 | 0.238 | 0.5144 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.055 | 0.9331 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.024 | 0.238 | 0.238 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.024 | 0.238 | 0.5144 |
Trypanosoma brucei | Valosin-containing protein | 0.055 | 0.9331 | 1 |
Giardia lamblia | AAA family ATPase | 0.0347 | 0.4783 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.058 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0134 | 0 | 0.5 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0347 | 0.4783 | 0.4783 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0347 | 0.4783 | 0.4783 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0134 | 0 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.055 | 0.9331 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.055 | 0.9331 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.0347 | 0.4783 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.055 | 0.9331 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.055 | 0.9331 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.058 | 1 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.055 | 0.9331 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.034 | 0.4627 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.058 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 55 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay | ChEMBL. | 23324406 |
IC50 (binding) | = 95 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay in presence of 0.05% BSA | ChEMBL. | 23324406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.