Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | GMP reductase | 0.0134 | 1 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0134 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0134 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0134 | 1 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0105 | 0.6139 | 0.611 |
Leishmania major | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Echinococcus multilocularis | histone deacetylase | 0.0105 | 0.6139 | 0.1677 |
Giardia lamblia | Histone deacetylase | 0.0099 | 0.5362 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0099 | 0.5362 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0117 | 0.7844 | 0.5351 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0117 | 0.7844 | 0.5351 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0099 | 0.5362 | 0.5327 |
Leishmania major | guanosine monophosphate reductase | 0.0134 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0105 | 0.6139 | 0.1677 |
Brugia malayi | Histone deacetylase 1 | 0.0099 | 0.5362 | 0.5327 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0105 | 0.6139 | 0.1677 |
Echinococcus granulosus | histone deacetylase 6 | 0.0105 | 0.6139 | 0.1677 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0099 | 0.5362 | 0.5362 |
Trypanosoma brucei | GMP reductase | 0.0134 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0099 | 0.5362 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0105 | 0.6139 | 0.1677 |
Loa Loa (eye worm) | GMP reductase | 0.0059 | 0.0075 | 0.0075 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0099 | 0.5362 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0105 | 0.6139 | 0.1677 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0134 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0105 | 0.6139 | 0.1677 |
Plasmodium vivax | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Leishmania major | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Onchocerca volvulus | Putative GMP reductase | 0.0059 | 0.0075 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0075 | 0.2144 | 0.2085 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0099 | 0.5362 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Trypanosoma brucei | histone deacetylase 3 | 0.0105 | 0.6139 | 0.1677 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0099 | 0.5362 | 0.5327 |
Echinococcus granulosus | histone deacetylase | 0.0105 | 0.6139 | 0.1677 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0099 | 0.5362 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0105 | 0.6139 | 0.1677 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0105 | 0.6139 | 0.1677 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0134 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0105 | 0.6139 | 0.1677 |
Toxoplasma gondii | IMP dehydrogenas | 0.0134 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0134 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0105 | 0.6139 | 0.1677 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0099 | 0.5362 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1704 | 0.1704 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0105 | 0.6139 | 0.6139 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5362 | 0.5362 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0134 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0105 | 0.6139 | 0.1677 |
Trypanosoma brucei | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0099 | 0.5362 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0099 | 0.5362 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0105 | 0.6139 | 0.1677 |
Entamoeba histolytica | histone deacetylase, putative | 0.0099 | 0.5362 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0105 | 0.6139 | 0.1677 |
Brugia malayi | Histone deacetylase family protein | 0.0105 | 0.6139 | 0.611 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0099 | 0.5362 | 0.5362 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0105 | 0.6139 | 0.6139 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0117 | 0.7844 | 0.5351 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0099 | 0.5362 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiparasitic activity against Cryptosporidium parvum infected in IL12 knockout mouse model at 250 mg/kg, po for 7 days | ChEMBL. | 23324406 | |
EC50 (functional) | = 0.4 uM | Antiparasitic activity against Cryptosporidium parvum IMPDH expressing Toxoplasma gondii assessed as growth inhibition | ChEMBL. | 23324406 |
EC50 (functional) | = 23 uM | Antiparasitic activity against wild type Toxoplasma gondii assessed as growth inhibition | ChEMBL. | 23324406 |
IC50 (binding) | = 13 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay | ChEMBL. | 23324406 |
IC50 (binding) | = 25 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay in presence of 0.05% BSA | ChEMBL. | 23324406 |
Kii (binding) | = 3.4 nM | Mixed type inhibition of recombinant Cryptosporidium parvum IMPDH with respect to NAD+ | ChEMBL. | 23324406 |
Kis (binding) | = 3.4 nM | Mixed type inhibition of recombinant Cryptosporidium parvum IMPDH with respect to NAD+ | ChEMBL. | 23324406 |
T1/2 (ADMET) | = 79 min | Half life in mouse liver microsomes | ChEMBL. | 23324406 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 23324406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.