Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Mus musculus | thromboxane A2 receptor | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 1 (subtype EP1) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 2 (subtype EP2) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 32 mmHg | Antihypertensive activity in mouse assessed as sulprostone-induced mean arterial pressure at 5 mg/kg, sc administered 2 hr prior to sulprostone-challenge (Rvb = 53.3 +/- 2.3 mmHg) | ChEMBL. | 23218714 |
Kd (binding) | = 7.39 | Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx | ChEMBL. | 23218714 |
Kd (binding) | = 40.7 nM | Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx | ChEMBL. | 23218714 |
Ki (binding) | > 6 | Antagonist activity at mouse TP receptor | ChEMBL. | 23218714 |
Ki (binding) | > 6 | Antagonist activity at mouse EP4 receptor | ChEMBL. | 23218714 |
Ki (binding) | > 6 | Antagonist activity at mouse EP2 receptor | ChEMBL. | 23218714 |
Ki (binding) | = 6.97 | Antagonist activity at mouse EP3 receptor | ChEMBL. | 23218714 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.