TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 290.357 | Formula: C16H22N2O3
H donors: 1 H acceptors: 1 LogP: 3.37 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCNC(=O)Oc1cccc(c1)C1=NCCO1
InChi: 1S/C16H22N2O3/c1-2-3-4-5-9-18-16(19)21-14-8-6-7-13(12-14)15-17-10-11-20-15/h6-8,12H,2-5,9-11H2,1H3,(H,18,19)
InChiKey: DOAANJRARCETMX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0434	1	1
Echinococcus multilocularis	tensin	0.0261	0.4424	0.4424
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0434	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0434	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0261	0.4424	0.4424
Echinococcus multilocularis	transfer RNA-Thr	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0434	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	activated cdc42 kinase 1	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0434	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/Met protein kinase	0.0173	0.1616	0.1616
Giardia lamblia	Protein 21.1	0.0173	0.1616	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0261	0.4424	0.3349
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0434	1	1
Echinococcus multilocularis	SH2 motif	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine protein kinase	0.0173	0.1616	0.1616
Brugia malayi	hypothetical protein	0.0261	0.4424	0.4424
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine kinase	0.0434	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0261	0.4424	0.4424
Brugia malayi	Tensin	0.0261	0.4424	0.4424
Echinococcus granulosus	raf serine:threonine protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	ephrin type A receptor 4 A	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	SH2 motif	0.0261	0.4424	0.4424
Brugia malayi	Guanylyl cyclase protein 23	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0173	0.1616	0.1616
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0261	0.4424	0.4424
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Schistosoma mansoni	growth factor receptor-bound protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase shark	0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis		0.0261	0.4424	0.4424
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0261	0.4424	0.4424
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0173	0.1616	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0434	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0261	0.4424	0.4424
Brugia malayi	Sex muscle abnormal protein 5	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	heat shock protein 70	0.0173	0.1616	0.1616
Schistosoma mansoni	tensin-related	0.0261	0.4424	0.4424
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0434	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0434	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0173	0.1616	0.1616
Brugia malayi	integrin-linked kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0173	0.1616	0.1616
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0173	0.1616	0.1616
Onchocerca volvulus		0.0261	0.4424	0.3349
Brugia malayi	Tyrosine-protein kinase abl-1	0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0261	0.4424	0.4424
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0173	0.1616	0.1616
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0173	0.1616	0.1616
Schistosoma mansoni	ephrin receptor	0.0173	0.1616	0.1616
Entamoeba histolytica	protein kinase, putative	0.0261	0.4424	0.3349
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Schistosoma mansoni	tensin	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	ephrin receptor	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Plasmodium falciparum	protein kinase, putative	0.0173	0.1616	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	SH2 domain containing protein 7	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	hypothetical protein	0.0261	0.4424	0.4424
Echinococcus multilocularis	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	SH2 motif	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Schistosoma mansoni	tensin	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0434	1	1
Schistosoma mansoni	tensin	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0173	0.1616	0.1616
Brugia malayi	RhoGAP domain containing protein	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase csk	0.0173	0.1616	0.1616
Echinococcus multilocularis	SH2 domain containing protein 7	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	activated cdc42 kinase 1	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	activin receptor type	0.0173	0.1616	0.1616
Plasmodium vivax	protein kinase, putative	0.0173	0.1616	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0173	0.1616	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0434	1	1
Echinococcus multilocularis	protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0173	0.1616	0.1616
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0434	1	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	STAT protein	0.0261	0.4424	0.4424
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0261	0.4424	0.3349
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Brugia malayi	hypothetical protein	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0434	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0173	0.1616	0.1616
Trypanosoma cruzi	protein kinase, putative	0.0173	0.1616	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0173	0.1616	0.5
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0434	1	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0173	0.1616	0.1616
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0173	0.1616	0.5
Schistosoma mansoni	vav2	0.0261	0.4424	0.4424
Loa Loa (eye worm)	SH2 domain-containing protein	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Onchocerca volvulus		0.0261	0.4424	0.3349
Brugia malayi	protein-tyrosine kinase	0.0434	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0434	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.1616	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0434	1	1
Onchocerca volvulus		0.0434	1	1
Onchocerca volvulus		0.0261	0.4424	0.3349
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0173	0.1616	0.1616
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0261	0.4424	0.4424
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Giardia lamblia	Kinase, NEK	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/EPH protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	integrin linked protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0261	0.4424	0.4424
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine kinase	0.0434	1	1
Trichomonas vaginalis	STE family protein kinase	0.0173	0.1616	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0173	0.1616	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0434	1	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0173	0.1616	0.1616
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.1616	0.5
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	hypothetical protein	0.0434	1	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0173	0.1616	0.1616
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0434	1	1
Echinococcus multilocularis	SH2 motif	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	adapter molecule crk	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Giardia lamblia	Kinase	0.0173	0.1616	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0173	0.1616	0.1616
Toxoplasma gondii	protein kinase domain-containing protein	0.0173	0.1616	0.5
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0434	1	1
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Onchocerca volvulus		0.0261	0.4424	0.3349
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	tensin	0.0261	0.4424	0.4424
Schistosoma mansoni	protein tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase csk	0.0173	0.1616	0.1616
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0261	0.4424	0.4424
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0434	1	1
Echinococcus granulosus	insulin receptor	0.0173	0.1616	0.1616
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/ALK protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0434	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0434	1	1
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Schistosoma mansoni	hypothetical protein	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Echinococcus granulosus	N chimaerin	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Protein kinase domain containing protein	0.0434	1	1
Brugia malayi	SH2 domain containing protein	0.0261	0.4424	0.4424
Entamoeba histolytica	SH2 domain containing protein	0.0261	0.4424	0.3349
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0261	0.4424	0.4424
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0434	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0173	0.1616	0.5
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	expressed conserved protein	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0173	0.1616	0.1616
Onchocerca volvulus		0.0434	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0173	0.1616	0.1616
Echinococcus multilocularis	epidermal growth factor receptor	0.0173	0.1616	0.1616
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0173	0.1616	0.5
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0434	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0434	1	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Echinococcus multilocularis	c src tyrosine kinase	0.0434	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	TK family protein kinase	0.0173	0.1616	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0261	0.4424	0.4424
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0434	1	1
Echinococcus multilocularis	FL cytokine receptor	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Brugia malayi	SH2 domain containing protein	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase pr2	0.0173	0.1616	0.1616
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0173	0.1616	0.5
Echinococcus multilocularis	protein kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0173	0.1616	0.1616
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase csk	0.0173	0.1616	0.1616
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0173	0.1616	0.1616
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0173	0.1616	0.1616
Brugia malayi	hypothetical protein	0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0434	1	1
Brugia malayi	SH2 domain containing protein	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Brugia malayi	Tyrosine-protein kinase PR2	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Onchocerca volvulus		0.0434	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Onchocerca volvulus		0.0261	0.4424	0.3349
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0434	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0173	0.1616	0.1616
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0261	0.4424	0.4424
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0261	0.4424	0.4424
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Toxoplasma gondii	STE kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	hypothetical protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0173	0.1616	0.1616
Echinococcus granulosus	signal transduction protein lnk realted	0.0261	0.4424	0.4424
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	SRC-1	0.0434	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0173	0.1616	0.1616
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0434	1	1
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0173	0.1616	0.5
Schistosoma mansoni	tyrosine kinase	0.0434	1	1
Brugia malayi	Raf kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Brugia malayi	Variant SH3 domain containing protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0261	0.4424	0.4424
Echinococcus granulosus	epidermal growth factor receptor	0.0173	0.1616	0.1616
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0261	0.4424	0.3349
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FAK protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0173	0.1616	0.1616
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Toxoplasma gondii	protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.1616	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/ACK protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0261	0.4424	0.4424
Echinococcus granulosus	c src tyrosine kinase	0.0434	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0173	0.1616	0.5
Brugia malayi	SH2 domain containing protein	0.0261	0.4424	0.4424
Schistosoma mansoni	tensin-related	0.0261	0.4424	0.4424
Echinococcus multilocularis	integrin linked protein kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Onchocerca volvulus		0.0434	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0173	0.1616	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0434	1	1
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Echinococcus granulosus	protein tyrosine kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Echinococcus multilocularis	NCK adaptor protein	0.0261	0.4424	0.4424
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0434	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0173	0.1616	0.1616
Leishmania major	protein kinase, putative	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Leishmania major	protein kinase, putative	0.0173	0.1616	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Brugia malayi	SH2 domain containing protein	0.0261	0.4424	0.4424
Echinococcus multilocularis	tyrosine kinase	0.0434	1	1
Echinococcus granulosus	protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0261	0.4424	0.4424
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0434	1	1
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Brugia malayi	C-terminal src kinase protein 1	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Schistosoma mansoni	tyrosine kinase	0.0434	1	1
Schistosoma mansoni	serine/threonine RGC	0.0173	0.1616	0.1616
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0261	0.4424	0.4424
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Brugia malayi	SH2 domain containing protein	0.0434	1	1
Echinococcus multilocularis	activin receptor type	0.0173	0.1616	0.1616
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0261	0.4424	0.4424
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase Srms	0.0434	1	1
Onchocerca volvulus		0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus granulosus	tyrosine kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	shc transforming protein	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK protein kinase	0.0434	1	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0173	0.1616	0.1616
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	growth factor receptor bound protein 2	0.0261	0.4424	0.4424
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0173	0.1616	0.1616
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0173	0.1616	0.1616
Brugia malayi	SH2 domain containing protein	0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0173	0.1616	0.1616
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0173	0.1616	0.1616
Brugia malayi	Furin-like cysteine rich region family protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	hypothetical protein	0.0173	0.1616	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.1616	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0261	0.4424	0.4424
Echinococcus multilocularis	insulin receptor	0.0173	0.1616	0.1616
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.1616	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0434	1	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0173	0.1616	0.1616
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0434	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0261	0.4424	0.4424
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1616	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Leishmania major	hypothetical protein, conserved	0.0173	0.1616	0.5
Echinococcus multilocularis	N chimaerin	0.0261	0.4424	0.4424
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0434	1	1
Brugia malayi	SH2 domain containing protein	0.0261	0.4424	0.4424
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0434	1	1
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Giardia lamblia	Kinase, NEK	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0434	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Schistosoma mansoni	hypothetical protein	0.0261	0.4424	0.4424
Schistosoma mansoni	signal transduction protein lnk-related	0.0261	0.4424	0.4424
Echinococcus granulosus	tyrosine kinase	0.0434	1	1
Schistosoma mansoni	GTPase activating protein	0.0261	0.4424	0.4424
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0261	0.4424	0.4424
Echinococcus granulosus	epidermal growth factor receptor	0.0173	0.1616	0.1616
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0173	0.1616	0.1616
Onchocerca volvulus		0.0261	0.4424	0.3349
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0261	0.4424	0.4424
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0173	0.1616	0.1616
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0173	0.1616	0.1616
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.1616	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0434	1	1
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Brugia malayi	SH2 domain containing protein	0.0261	0.4424	0.4424
Schistosoma mansoni	suppressor of cytokine signaling	0.0261	0.4424	0.4424
Echinococcus granulosus	SH2 motif	0.0261	0.4424	0.4424
Echinococcus granulosus	tyrosine protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0261	0.4424	0.4424
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1616	0.1616
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0173	0.1616	0.1616
Echinococcus granulosus	tensin	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Brugia malayi	Receptor family ligand binding region containing protein	0.0173	0.1616	0.1616
Brugia malayi	SRC-1	0.0434	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0261	0.4424	0.4424
Schistosoma mansoni	nck2/grb4	0.0261	0.4424	0.4424
Onchocerca volvulus		0.0434	1	1
Trypanosoma brucei	protein kinase, putative	0.0173	0.1616	0.5
Plasmodium falciparum	protein kinase, putative	0.0173	0.1616	0.5
Trypanosoma cruzi	protein kinase, putative	0.0173	0.1616	0.5
Echinococcus granulosus	NCK adaptor protein	0.0261	0.4424	0.4424
Plasmodium falciparum	protein kinase, putative	0.0173	0.1616	0.5
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Trichomonas vaginalis	protein kinase atn1, putative	0.0173	0.1616	0.5
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0173	0.1616	0.1616
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0261	0.4424	0.4424
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0173	0.1616	0.1616
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0173	0.1616	0.1616
Schistosoma mansoni	protein kinase	0.0173	0.1616	0.1616
Schistosoma mansoni	SH2A	0.0261	0.4424	0.4424
Brugia malayi	ephrin receptor 1 precursor	0.0173	0.1616	0.1616
Plasmodium falciparum	tyrosine kinase-like protein	0.0173	0.1616	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0173	0.1616	0.1616
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Brugia malayi	Variant SH3 domain containing protein	0.0261	0.4424	0.4424
Schistosoma mansoni	tyrosine kinase	0.0173	0.1616	0.1616
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1616	0.1616
Echinococcus granulosus	receptor type guanylyl cyclase	0.0173	0.1616	0.1616
Trichomonas vaginalis	TKL family protein kinase	0.0173	0.1616	0.5
Loa Loa (eye worm)	TK protein kinase	0.0173	0.1616	0.1616
Loa Loa (eye worm)	SH2 domain-containing protein	0.0261	0.4424	0.4424
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0261	0.4424	0.4424

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.93	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production incubated for 45 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis	ChEMBL.	23214511
IC50 (binding)	= 9.26	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production incubated for 90 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis	ChEMBL.	23214511
IC50 (binding)	= 0.55 nM	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production incubated for 90 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis	ChEMBL.	23214511
IC50 (binding)	= 1.2 nM	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production incubated for 45 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis	ChEMBL.	23214511
Inhibition (binding)	= 9 %	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production at 0.1 nM incubated for 60 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL.	23214511
Inhibition (binding)	= 74 %	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production at 1 nM incubated for 60 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL.	23214511
Inhibition (binding)	= 100 %	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production at 100 nM incubated for 60 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL.	23214511
Inhibition (binding)	= 100 %	Inhibition of FAAH-mediated [3H]anandamide hydrolysis in rat brain homogenate assessed as [3H]ethanolamine production at 10 nM incubated for 60 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL.	23214511

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2314112

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1739190