Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0305 | 0.0711 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1087 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0799 | 0.6244 | 0.6244 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1087 | 0.9471 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0305 | 0.0711 | 0.075 |
Plasmodium vivax | vivapain-2 | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0441 | 0.2234 | 0.0438 |
Brugia malayi | Cathepsin L-like precursor | 0.0441 | 0.2234 | 0.2358 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0441 | 0.2234 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0441 | 0.2234 | 0.1738 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0441 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0441 | 0.2234 | 0.2358 |
Onchocerca volvulus | 0.0441 | 0.2234 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0441 | 0.2234 | 0.2358 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0441 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.041 | 0.1877 | 0.1877 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0441 | 0.2234 | 0.2358 |
Leishmania major | cathepsin L-like protease | 0.0441 | 0.2234 | 0.0438 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0305 | 0.0711 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.041 | 0.1877 | 0.8406 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Onchocerca volvulus | 0.0441 | 0.2234 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0305 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.041 | 0.1877 | 0.1982 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1087 | 0.9471 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0441 | 0.2234 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0441 | 0.2234 | 0.0438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.1087 | 0.9471 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0305 | 0.0711 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.0441 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1087 | 0.9471 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0441 | 0.2234 | 0.1738 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.041 | 0.1877 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0441 | 0.2234 | 0.1738 |
Onchocerca volvulus | 0.0441 | 0.2234 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0441 | 0.2234 | 0.1738 |
Leishmania major | cathepsin L-like protease | 0.0441 | 0.2234 | 0.0438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0441 | 0.2234 | 0.2358 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0441 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0441 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.041 | 0.1877 | 0.1332 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0441 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0305 | 0.0711 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.2234 | 0.1738 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1087 | 0.9471 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1134 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0305 | 0.0711 | 0.075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1087 | 0.9471 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1134 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0441 | 0.2234 | 0.2358 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1134 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0441 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0441 | 0.2234 | 0.2358 |
Leishmania major | cathepsin L-like protease | 0.1134 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1134 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1134 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1087 | 0.9471 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0441 | 0.2234 | 0.2358 |
Onchocerca volvulus | 0.0441 | 0.2234 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1087 | 0.9471 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0441 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0305 | 0.0711 | 0.075 |
Echinococcus multilocularis | cysteine protease | 0.0441 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0441 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0441 | 0.2234 | 0.2234 |
Loa Loa (eye worm) | cysteine protease | 0.0441 | 0.2234 | 0.1738 |
Giardia lamblia | Cathepsin B precursor | 0.041 | 0.1877 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0441 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.041 | 0.1877 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.1087 | 0.9471 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0305 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0441 | 0.2234 | 0.2358 |
Leishmania major | cathepsin L-like protease | 0.0441 | 0.2234 | 0.0438 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0441 | 0.2234 | 1 |
Onchocerca volvulus | 0.0441 | 0.2234 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0441 | 0.2234 | 0.0438 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0441 | 0.2234 | 0.2358 |
Toxoplasma gondii | cathepsin CPL | 0.0441 | 0.2234 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0998 | 0.8477 | 0.8477 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.041 | 0.1877 | 0.1877 |
Onchocerca volvulus | 0.0441 | 0.2234 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1134 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0441 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0441 | 0.2234 | 0.2358 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0441 | 0.2234 | 0.2358 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1087 | 0.9471 | 0.9471 |
Onchocerca volvulus | 0.0441 | 0.2234 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23291116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.