Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.006 | 0.3425 | 0.8134 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0011 | 0 | 0.5 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0042 | 0.2216 | 0.5 |
Schistosoma mansoni | endonuclease related | 0.0042 | 0.2216 | 0.2216 |
Trypanosoma cruzi | endonuclease G, putative | 0.0042 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0071 | 0.4211 | 0.4211 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0071 | 0.4211 | 0.4211 |
Onchocerca volvulus | 0.0153 | 1 | 1 | |
Leishmania major | endonuclease G, putative | 0.0042 | 0.2216 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0153 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0071 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3425 | 0.3425 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0042 | 0.2216 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0042 | 0.2216 | 0.5 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | Endonuclease G | 0.0042 | 0.2216 | 0.5262 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.006 | 0.3425 | 0.8134 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0042 | 0.2216 | 0.5 |
Echinococcus granulosus | Endonuclease G | 0.0042 | 0.2216 | 0.5262 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4211 | 0.4211 |
Echinococcus granulosus | ectonucleotide | 0.006 | 0.3425 | 0.8134 |
Trypanosoma brucei | endonuclease G, putative | 0.0042 | 0.2216 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0042 | 0.2216 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0042 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0071 | 0.4211 | 0.4211 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0071 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.4211 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0042 | 0.2216 | 1 |
Onchocerca volvulus | 0.0071 | 0.4211 | 0.4211 | |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0042 | 0.2216 | 0.2216 |
Onchocerca volvulus | 0.0071 | 0.4211 | 0.4211 | |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4211 | 0.4211 |
Mycobacterium leprae | hypothetical protein | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.006 | 0.3425 | 0.8134 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.4 uM | Inhibition of BF3 site of androgen receptor in human LNCAP cells expressing ARR2PB after 3 days by eGFP transcriptional assay | ChEMBL. | 23301637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.