TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 379.836 | Formula: C22H18ClNO3
H donors: 2 H acceptors: 2 LogP: 6.07 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c2c1cccc2)OCCCc1c([nH]c2c1cccc2)C(=O)O
InChi: 1S/C22H18ClNO3/c23-18-11-12-20(16-8-2-1-6-14(16)18)27-13-5-9-17-15-7-3-4-10-19(15)24-21(17)22(25)26/h1-4,6-8,10-12,24H,5,9,13H2,(H,25,26)
InChiKey: TZQCEYIFNGTDNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	myeloid cell leukemia 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0947	1	1
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.01	0.073	0.0711
Loa Loa (eye worm)	TK/FER protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Plasmodium falciparum	protein kinase, putative	0.0198	0.1798	0.5
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Schistosoma mansoni	hypothetical protein	0.01	0.073	0.073
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0198	0.1798	0.1798
Echinococcus multilocularis	protein kinase	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/FER protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0513	0.5252	0.5252
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0316	0.3089	0.3089
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Echinococcus multilocularis	SHC transforming protein 3	0.0316	0.3089	0.3075
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0316	0.3089	0.3075
Schistosoma mansoni	hypothetical protein	0.0166	0.145	0.145
Loa Loa (eye worm)	serine/threonine protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0513	0.5252	0.5242
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0947	1	1
Plasmodium falciparum	protein kinase, putative	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK protein kinase	0.0513	0.5252	0.5252
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	hypothetical protein	0.0316	0.3089	0.3089
Schistosoma mansoni	serine/threonine protein kinase	0.0198	0.1798	0.1798
Onchocerca volvulus		0.0513	0.5252	1
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0513	0.5252	0.5242
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0316	0.3089	0.3075
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine protein kinase Srms	0.0513	0.5252	0.5242
Trichomonas vaginalis	STE family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0198	0.1798	0.1781
Schistosoma mansoni	nck2/grb4	0.0316	0.3089	0.3089
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0947	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0513	0.5252	0.5242
Brugia malayi	Variant SH3 domain containing protein	0.0316	0.3089	0.3089
Schistosoma mansoni	tensin-related	0.0316	0.3089	0.3089
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0198	0.1798	0.1798
Echinococcus multilocularis	NCK adaptor protein	0.0316	0.3089	0.3075
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Schistosoma mansoni	ephrin receptor	0.0198	0.1798	0.1798
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0198	0.1798	0.1781
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0198	0.1798	0.5
Schistosoma mansoni	serine/threonine RGC	0.0198	0.1798	0.1798
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	growth factor receptor-bound protein	0.0316	0.3089	0.3089
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0198	0.1798	0.1781
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Echinococcus granulosus	insulin receptor	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0198	0.1798	0.1798
Brugia malayi	SH2 domain containing protein	0.0316	0.3089	0.3089
Echinococcus granulosus	activated cdc42 kinase 1	0.0198	0.1798	0.1781
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.01	0.073	0.0711
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.1798	0.5
Brugia malayi	SH2 domain containing protein	0.0316	0.3089	0.3089
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0316	0.3089	0.3089
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0169	0.0169
Loa Loa (eye worm)	TK/CSK protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.037	0.3686	0.3686
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	vav2	0.0316	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0513	0.5252	0.5242
Entamoeba histolytica	receptor protein kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Brugia malayi	integrin-linked kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	shc transforming protein	0.0316	0.3089	0.3089
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0316	0.3089	0.3075
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	protein kinase	0.0198	0.1798	0.1781
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0198	0.1798	0.1781
Echinococcus multilocularis	signal transduction protein lnk realted	0.0316	0.3089	0.3075
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus granulosus	SH2 motif	0.0316	0.3089	0.3075
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	hypothetical protein	0.01	0.073	0.073
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Echinococcus multilocularis	epidermal growth factor receptor	0.0198	0.1798	0.1781
Echinococcus granulosus	tensin	0.0316	0.3089	0.3075
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0198	0.1798	0.5
Brugia malayi	Protein kinase domain containing protein	0.0513	0.5252	0.5252
Echinococcus multilocularis	transcription factor Dp 1	0.0548	0.5635	0.5626
Brugia malayi	Tensin	0.0316	0.3089	0.3089
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0947	1	1
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0316	0.3089	0.3075
Giardia lamblia	Kinase, NEK	0.0198	0.1798	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Echinococcus granulosus	NCK adaptor protein	0.0316	0.3089	0.3075
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0316	0.3089	0.3089
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	protein kinase atn1, putative	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.01	0.073	0.073
Echinococcus granulosus	tyrosine kinase	0.0513	0.5252	0.5242
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0513	0.5252	0.5242
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0198	0.1798	0.1781
Echinococcus multilocularis	geminin	0.0166	0.145	0.1432
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Onchocerca volvulus		0.0513	0.5252	1
Brugia malayi	Protein kinase domain containing protein	0.0513	0.5252	0.5252
Loa Loa (eye worm)	TK/INSR protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0169	0.0169
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0316	0.3089	0.374
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0198	0.1798	0.1781
Giardia lamblia	Kinase	0.0198	0.1798	0.5
Echinococcus granulosus	N chimaerin	0.0316	0.3089	0.3075
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0169	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0198	0.1798	0.1781
Onchocerca volvulus		0.0513	0.5252	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0513	0.5252	0.5242
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0513	0.5252	0.5242
Schistosoma mansoni	serine/threonine protein kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	TK/FER protein kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0513	0.5252	0.5242
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.1798	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0198	0.1798	0.1781
Brugia malayi	Tyrosine-protein kinase PR2	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Onchocerca volvulus		0.0513	0.5252	1
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0198	0.1798	0.1798
Schistosoma mansoni	protein tyrosine kinase	0.0198	0.1798	0.1798
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0198	0.1798	0.1781
Echinococcus multilocularis	SH2 motif	0.0316	0.3089	0.3075
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.01	0.073	0.073
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0947	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.01	0.073	0.0711
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TK family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.01	0.073	0.073
Echinococcus granulosus	tyrosine protein kinase pr2	0.0198	0.1798	0.1781
Brugia malayi	SH2 domain containing protein	0.0316	0.3089	0.3089
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0365	0.3625	0.3625
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0198	0.1798	0.1781
Schistosoma mansoni	tyrosine kinase	0.0513	0.5252	0.5252
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0316	0.3089	0.3075
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Echinococcus granulosus	protein tyrosine kinase	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0316	0.3089	0.3075
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0316	0.3089	0.3075
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0316	0.3089	0.3075
Echinococcus granulosus	activated cdc42 kinase 1	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0198	0.1798	0.1798
Plasmodium vivax	protein kinase, putative	0.0198	0.1798	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0198	0.1798	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/ALK protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.1798	0.5
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus multilocularis	tyrosine protein kinase csk	0.0198	0.1798	0.1781
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Brugia malayi	C-terminal src kinase protein 1	0.0198	0.1798	0.1798
Schistosoma mansoni	hypothetical protein	0.01	0.073	0.073
Loa Loa (eye worm)	TK/Met protein kinase	0.0198	0.1798	0.1798
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0513	0.5252	0.5242
Echinococcus granulosus	signal transduction protein lnk realted	0.0316	0.3089	0.3075
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0198	0.1798	0.5
Schistosoma mansoni	hypothetical protein	0.0316	0.3089	0.3089
Schistosoma mansoni	tyrosine kinase	0.0513	0.5252	0.5252
Loa Loa (eye worm)	TK/FER protein kinase	0.0198	0.1798	0.1798
Brugia malayi	SH2 domain containing protein	0.0316	0.3089	0.3089
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0198	0.1798	0.1798
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0198	0.1798	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.002	0.002
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0198	0.1798	0.1781
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0198	0.1798	0.1798
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0198	0.1798	0.1798
Echinococcus multilocularis	tyrosine protein kinase csk	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0198	0.1798	0.1781
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0513	0.5252	0.5252
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Schistosoma mansoni	suppressor of cytokine signaling	0.0316	0.3089	0.3089
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	hypothetical protein	0.0316	0.3089	0.3075
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Entamoeba histolytica	serine/threonine kinase, putative	0.0198	0.1798	0.1781
Brugia malayi	Variant SH3 domain containing protein	0.0316	0.3089	0.3089
Brugia malayi	Variant SH3 domain containing protein	0.0316	0.3089	0.3089
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0316	0.3089	0.3075
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Onchocerca volvulus		0.0316	0.3089	0.374
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0947	1	1
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0316	0.3089	0.3089
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0169	0.0169
Onchocerca volvulus		0.0316	0.3089	0.374
Echinococcus granulosus	SHC transforming protein 3	0.0316	0.3089	0.3075
Echinococcus multilocularis	insulin receptor	0.0198	0.1798	0.1781
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0947	1	1
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0316	0.3089	0.3075
Loa Loa (eye worm)	hypothetical protein	0.0513	0.5252	0.5252
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0198	0.1798	0.1798
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Echinococcus multilocularis		0.0316	0.3089	0.3075
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.1798	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0513	0.5252	0.5242
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Onchocerca volvulus		0.0316	0.3089	0.374
Entamoeba histolytica	SH2 domain containing protein	0.0316	0.3089	0.3075
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0316	0.3089	0.3089
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	SRC-1	0.0513	0.5252	0.5252
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.01	0.073	0.0711
Schistosoma mansoni	adapter molecule crk	0.0316	0.3089	0.3089
Echinococcus multilocularis	tensin	0.0316	0.3089	0.3075
Schistosoma mansoni	tyrosine kinase	0.0513	0.5252	0.5252
Giardia lamblia	Kinase, NEK	0.0198	0.1798	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0316	0.3089	0.3089
Plasmodium falciparum	tyrosine kinase-like protein	0.0198	0.1798	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Brugia malayi	protein-tyrosine kinase	0.0513	0.5252	0.5252
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Echinococcus multilocularis	N chimaerin	0.0316	0.3089	0.3075
Echinococcus multilocularis	epidermal growth factor receptor	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Schistosoma mansoni	suppressor of cytokine signaling	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0316	0.3089	0.3089
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	tyrosin kinase, putative	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0198	0.1798	0.1798
Trichomonas vaginalis	AGC family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Loa Loa (eye worm)	STAT protein	0.0316	0.3089	0.3089
Echinococcus granulosus	tyrosine protein kinase HCK	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine protein kinase csk	0.0198	0.1798	0.1781
Brugia malayi	Furin-like cysteine rich region family protein	0.0198	0.1798	0.1798
Brugia malayi	Tyrosine-protein kinase abl-1	0.0513	0.5252	0.5252
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Echinococcus granulosus	ephrin type A receptor 4 A	0.0198	0.1798	0.1781
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.1798	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0198	0.1798	0.1781
Echinococcus multilocularis	protein tyrosine kinase	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Echinococcus multilocularis	c src tyrosine kinase	0.0513	0.5252	0.5242
Entamoeba histolytica	serine/threonine kinase, putative	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0198	0.1798	0.1781
Schistosoma mansoni	serine/threonine protein kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0513	0.5252	0.5242
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0513	0.5252	0.5242
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Raf kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0198	0.1798	0.1781
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0198	0.1798	0.1781
Echinococcus granulosus	epidermal growth factor receptor	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	apoptosis regulator protein	0.01	0.073	0.073
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0513	0.5252	0.5242
Onchocerca volvulus		0.0513	0.5252	1
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Echinococcus multilocularis	activin receptor type	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Protein kinase domain containing protein	0.0513	0.5252	0.5252
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Brugia malayi	SH2 domain containing protein	0.0513	0.5252	0.5252
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Echinococcus multilocularis	activated cdc42 kinase 1	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0198	0.1798	0.1781
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0316	0.3089	0.3075
Loa Loa (eye worm)	SH2 domain-containing protein	0.0316	0.3089	0.3089
Echinococcus multilocularis	SH2 domain containing protein 7	0.0316	0.3089	0.3075
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Plasmodium falciparum	protein kinase, putative	0.0198	0.1798	0.5
Echinococcus granulosus	geminin	0.0166	0.145	0.1432
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0316	0.3089	0.3089
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0316	0.3089	0.374
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0513	0.5252	0.5242
Brugia malayi	Guanylyl cyclase protein 23	0.0198	0.1798	0.1798
Entamoeba histolytica	serine/threonine kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0198	0.1798	0.1781
Loa Loa (eye worm)	SH2 domain-containing protein	0.0316	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0316	0.3089	0.3075
Entamoeba histolytica	serine/threonine kinase, putative	0.0198	0.1798	0.1781
Echinococcus granulosus	c src tyrosine kinase	0.0513	0.5252	0.5242
Echinococcus granulosus	growth factor receptor bound protein 2	0.0316	0.3089	0.3075
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0316	0.3089	0.3089
Brugia malayi	SH2 domain containing protein	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0316	0.3089	0.3075
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Onchocerca volvulus		0.0513	0.5252	1
Echinococcus granulosus	protein kinase	0.0198	0.1798	0.1781
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0198	0.1798	0.1781
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0359	0.3567	1
Echinococcus multilocularis	SH2 motif	0.0316	0.3089	0.3075
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Echinococcus granulosus	traf and tnf receptor associated protein	0.037	0.3686	0.3673
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0316	0.3089	0.3075
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0198	0.1798	0.1781
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0316	0.3089	0.3089
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Onchocerca volvulus		0.0316	0.3089	0.374
Brugia malayi	SRC-1	0.0513	0.5252	0.5252
Onchocerca volvulus		0.0316	0.3089	0.374
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0316	0.3089	0.3089
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	tyrosine kinase	0.0513	0.5252	0.5252
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine kinase	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0513	0.5252	0.5242
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Echinococcus granulosus	SH2 domain containing protein 7	0.0316	0.3089	0.3075
Echinococcus multilocularis	FL cytokine receptor	0.0198	0.1798	0.1781
Schistosoma mansoni	protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0198	0.1798	0.1781
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0198	0.1798	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0513	0.5252	0.5252
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Echinococcus granulosus	SH2 motif	0.0316	0.3089	0.3075
Brugia malayi	hypothetical protein	0.0035	0.002	0.002
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0316	0.3089	0.3075
Echinococcus granulosus	natriuretic peptide receptor 1	0.0198	0.1798	0.1781
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0316	0.3089	0.3089
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0198	0.1798	0.1781
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0198	0.1798	0.1781
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/FAK protein kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	activin receptor type	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	hypothetical protein	0.0513	0.5252	0.5252
Echinococcus multilocularis	tyrosine protein kinase csk	0.0198	0.1798	0.1781
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Entamoeba histolytica	hypothetical protein, conserved	0.0198	0.1798	0.1781
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Echinococcus multilocularis	heat shock protein 70	0.0198	0.1798	0.1781
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine protein kinase shark	0.0513	0.5252	0.5242
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0316	0.3089	0.3075
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0316	0.3089	0.3089
Echinococcus multilocularis	tyrosine kinase	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0947	1	1
Schistosoma mansoni	tyrosine kinase	0.0513	0.5252	0.5252
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine protein kinase	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Entamoeba histolytica	tyrosin kinase, putative	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus granulosus	transcription factor Dp 1	0.0548	0.5635	0.5626
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	hypothetical protein	0.0198	0.1798	0.1781
Schistosoma mansoni	apoptosis regulator bax	0.01	0.073	0.073
Echinococcus multilocularis	integrin linked protein kinase	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0198	0.1798	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/EPH protein kinase	0.0198	0.1798	0.1798
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase csk	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Brugia malayi	hypothetical protein	0.0198	0.1798	0.1798
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0198	0.1798	0.1781
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	SH2 motif	0.0316	0.3089	0.3075
Schistosoma mansoni	hypothetical protein	0.0166	0.145	0.145
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0198	0.1798	0.1781
Schistosoma mansoni	tensin	0.0316	0.3089	0.3089
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	traf and tnf receptor associated protein	0.037	0.3686	0.3673
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0316	0.3089	0.3089
Entamoeba histolytica	receptor protein kinase, putative	0.0198	0.1798	0.1781
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0947	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0316	0.3089	0.3075
Onchocerca volvulus		0.0316	0.3089	0.374
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Echinococcus granulosus	kinase suppressor of Ras 1	0.0198	0.1798	0.1781
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0316	0.3089	0.3075
Loa Loa (eye worm)	TK/ACK protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	serine/threonine kinase, putative	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0198	0.1798	0.1781
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	tensin	0.0316	0.3089	0.3089
Loa Loa (eye worm)	TK/FER protein kinase	0.0198	0.1798	0.1798
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0513	0.5252	0.5242
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0198	0.1798	0.1781
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Brugia malayi	Sex muscle abnormal protein 5	0.0316	0.3089	0.3089
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Brugia malayi	Protein kinase domain containing protein	0.0513	0.5252	0.5252
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/ABL protein kinase	0.0513	0.5252	0.5252
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0513	0.5252	0.5242
Loa Loa (eye worm)	TK/ROR protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	CAMK family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1798	0.1781
Schistosoma mansoni	ephrin receptor	0.0198	0.1798	0.1798
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0198	0.1798	0.1798
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Echinococcus granulosus	receptor type guanylyl cyclase	0.0198	0.1798	0.1781
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Loa Loa (eye worm)	SH2 domain-containing protein	0.0316	0.3089	0.3089
Echinococcus multilocularis	tyrosine kinase	0.0513	0.5252	0.5242
Schistosoma mansoni	GTPase activating protein	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0198	0.1798	0.1798
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0513	0.5252	0.5242
Echinococcus granulosus	tyrosine protein kinase Blk	0.0513	0.5252	0.5242
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0513	0.5252	0.5242
Echinococcus multilocularis	tyrosine protein kinase shark	0.0513	0.5252	0.5242
Echinococcus multilocularis	tensin	0.0316	0.3089	0.3075
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0198	0.1798	0.1781
Entamoeba histolytica	ankyrin repeat protein	0.0198	0.1798	0.1781
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0198	0.1798	0.1798
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0513	0.5252	0.5242
Brugia malayi	ephrin receptor 1 precursor	0.0198	0.1798	0.1798
Schistosoma mansoni	hypothetical protein	0.0035	0.002	0.002
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Schistosoma mansoni	hypothetical protein	0.0198	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Schistosoma mansoni	tensin	0.0316	0.3089	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0316	0.3089	0.3075
Entamoeba histolytica	serine/threonine kinase, putative	0.0198	0.1798	0.1781
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0513	0.5252	0.5242
Entamoeba histolytica	ankyrin repeat protein	0.0198	0.1798	0.1781
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0198	0.1798	0.1798
Echinococcus granulosus	expressed conserved protein	0.0316	0.3089	0.3075
Brugia malayi	SH2 domain containing protein	0.0513	0.5252	0.5252
Brugia malayi	hypothetical protein	0.0198	0.1798	0.1798
Schistosoma mansoni	SH2A	0.0316	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0316	0.3089	0.3075
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Schistosoma mansoni	tensin-related	0.0316	0.3089	0.3089
Plasmodium falciparum	tyrosine kinase-like protein	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0513	0.5252	0.5252
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0316	0.3089	0.3089
Brugia malayi	SH2 domain containing protein	0.0316	0.3089	0.3089
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0198	0.1798	0.1798
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0198	0.1798	0.1781
Echinococcus granulosus	tyrosine kinase	0.0513	0.5252	0.5242
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Giardia lamblia	Protein 21.1	0.0198	0.1798	0.5
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1798	0.1798
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0513	0.5252	0.5242
Brugia malayi	SH2 domain containing protein	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase, putative	0.0316	0.3089	0.3075
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.1798	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0198	0.1798	0.1798
Schistosoma mansoni	tyrosine kinase	0.0198	0.1798	0.1798
Loa Loa (eye worm)	TK protein kinase	0.0198	0.1798	0.1798
Schistosoma mansoni	growth factor receptor-bound protein	0.0316	0.3089	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0316	0.3089	0.3089
Entamoeba histolytica	protein kinase, putative	0.0198	0.1798	0.1781
Brugia malayi	RhoGAP domain containing protein	0.0316	0.3089	0.3089
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0198	0.1798	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0198	0.1798	0.1781
Echinococcus granulosus	epidermal growth factor receptor	0.0198	0.1798	0.1781
Brugia malayi	Protein kinase domain containing protein	0.0198	0.1798	0.1798
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0198	0.1798	0.1798
Brugia malayi	hypothetical protein	0.0316	0.3089	0.3089
Entamoeba histolytica	tyrosin kinase, putative	0.0198	0.1798	0.1781

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.48 uM	Displacement of FITC-AHx-KALETLRRVGDGVQRNHETAF-NH2 from human MCl1 (172 to 327) expressed in Escherichia coli BL21 (DE3) after 1 hr by fluorescence polarization anisotropy assay	ChEMBL.	23244564

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2314200

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1739905