Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | G-protein coupled receptor | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | RE15519p | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0066 | 0.0973 | 0.0973 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0134 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0066 | 0.0973 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0134 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0066 | 0.0973 | 0.0973 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0134 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0066 | 0.0973 | 0.0973 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0075 | 0.2085 | 0.2085 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0066 | 0.0973 | 0.0973 |
Toxoplasma gondii | IMP dehydrogenas | 0.0134 | 1 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | larval opioid receptor | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | putative neuropeptide receptor | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | Dopamine receptor | 0.0066 | 0.0973 | 0.0973 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Trypanosoma cruzi | GMP reductase | 0.0134 | 1 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0134 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | sulfakinin receptor protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0066 | 0.0973 | 0.0973 |
Trypanosoma cruzi | GMP reductase | 0.0134 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Brugia malayi | Serotonin receptor | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0066 | 0.0973 | 0.0973 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0066 | 0.0973 | 0.0973 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | ORL1-like opioid receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0134 | 1 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0066 | 0.0973 | 0.0973 |
Trypanosoma brucei | GMP reductase | 0.0134 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0134 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0134 | 1 | 1 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Leishmania major | guanosine monophosphate reductase | 0.0134 | 1 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | G protein-coupled receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 1 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0066 | 0.0973 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0066 | 0.0973 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | follicle stimulating hormone receptor | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | Melatonin receptor type 1A | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0066 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0973 | 0.0973 |
Brugia malayi | AKH receptor | 0.0066 | 0.0973 | 0.0973 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay in presence of 0.05% BSA | ChEMBL. | 23324406 | |
IC50 (binding) | > 5000 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay | ChEMBL. | 23324406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.