Detailed information for compound 1740380

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.672 | Formula: C29H44N2O2
  • H donors: 2 H acceptors: 2 LogP: 8.54 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)N1CCc2c(C1)[nH]c1c2cc(cc1)O
  • InChi: 1S/C29H44N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29(33)31-21-20-25-26-22-24(32)18-19-27(26)30-28(25)23-31/h9-10,18-19,22,30,32H,2-8,11-17,20-21,23H2,1H3/b10-9-
  • InChiKey: WAUQCMVPPHRPSG-KTKRTIGZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Anandamide amidohydrolase Starlite/ChEMBL References
Rattus norvegicus Transient receptor potential cation channel subfamily A member 1 Starlite/ChEMBL References
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni transient receptor potential cation channel subfamily A member Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K04984 transient receptor potential cation channel, subfamily A, member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.7 %
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Anandamide amidohydrolase   579 aa 499 aa 24.6 %
Echinococcus multilocularis fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.3 %
Onchocerca volvulus Anandamide amidohydrolase   579 aa 539 aa 34.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei protein kinase, putative 0.0328 0.2913 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0499 0.5337 0.5339
Schistosoma mansoni tensin-related 0.0499 0.5337 0.5337
Brugia malayi Furin-like cysteine rich region family protein 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0828 0.9996 0.9996
Echinococcus granulosus epidermal growth factor receptor 0.0328 0.2913 0.2913
Echinococcus multilocularis protein tyrosine kinase 0.0328 0.2913 0.2913
Onchocerca volvulus 0.0499 0.5337 0.3423
Schistosoma mansoni serine/threonine RGC 0.0328 0.2913 0.2913
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0328 0.2913 0.2914
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0499 0.5337 0.5337
Brugia malayi tRNA modification GTPase TrmE family protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) hypothetical protein 0.0828 0.9996 1
Plasmodium falciparum protein kinase, putative 0.0328 0.2913 0.5
Brugia malayi Protein kinase domain containing protein 0.0828 0.9996 1
Echinococcus granulosus c src tyrosine kinase 0.0828 0.9996 0.9996
Echinococcus granulosus SH2 motif 0.0499 0.5337 0.5337
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Plasmodium vivax tyrosine kinase-like protein, putative 0.0328 0.2913 0.5
Echinococcus granulosus SH2 motif 0.0499 0.5337 0.5337
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Brugia malayi Tyrosine-protein kinase abl-1 0.0828 0.9996 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Echinococcus multilocularis tyrosine protein kinase HCK 0.0328 0.2913 0.2913
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0499 0.5337 0.5339
Echinococcus granulosus tyrosine protein kinase Src64B 0.0828 0.9996 0.9996
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/ABL protein kinase 0.0828 0.9996 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0328 0.2913 0.2913
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0328 0.2913 0.2914
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus granulosus NCK adaptor protein 0.0499 0.5337 0.5337
Brugia malayi Immunoglobulin I-set domain containing protein 0.0328 0.2913 0.2914
Brugia malayi Raf kinase 0.0328 0.2913 0.2914
Onchocerca volvulus 0.0499 0.5337 0.3423
Echinococcus multilocularis tyrosine protein kinase shark 0.0828 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.0328 0.2913 0.5
Echinococcus granulosus suppressor of cytokine signaling 7 0.0499 0.5337 0.5337
Echinococcus granulosus tyrosine protein kinase csk 0.0328 0.2913 0.2913
Schistosoma mansoni vav2 0.0499 0.5337 0.5337
Brugia malayi SH2 domain containing protein 0.0499 0.5337 0.5339
Echinococcus granulosus activated cdc42 kinase 1 0.0328 0.2913 0.2913
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Schistosoma mansoni nck2/grb4 0.0499 0.5337 0.5337
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0328 0.2913 0.2913
Schistosoma mansoni SH2A 0.0499 0.5337 0.5337
Echinococcus multilocularis protein KINase family member (kin 25) 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine protein kinase 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine protein kinase Blk 0.0828 0.9996 0.9996
Echinococcus multilocularis signal transduction protein lnk realted 0.0499 0.5337 0.5337
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0499 0.5337 0.5337
Schistosoma mansoni protein tyrosine kinase 0.0328 0.2913 0.2913
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0328 0.2913 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0328 0.2913 0.2913
Echinococcus multilocularis activated cdc42 kinase 1 0.0328 0.2913 0.2913
Echinococcus granulosus ephrin type A receptor 4 A 0.0328 0.2913 0.2913
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus tyrosine protein kinase HCK 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) serine/threonine protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0328 0.2913 0.2913
Toxoplasma gondii protein kinase 0.0328 0.2913 0.5
Leishmania major protein kinase, putative 0.0328 0.2913 0.5
Echinococcus multilocularis ankyrin repeat protein 0.0192 0.0977 0.0977
Schistosoma mansoni hypothetical protein 0.0328 0.2913 0.2913
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0328 0.2913 0.2913
Brugia malayi Receptor family ligand binding region containing protein 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Onchocerca volvulus 0.0499 0.5337 0.3423
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis ephrin type A receptor 4 A 0.0328 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/RYK protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0328 0.2913 0.2913
Trichomonas vaginalis TKL family protein kinase 0.0328 0.2913 1
Echinococcus multilocularis tensin 0.0499 0.5337 0.5337
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Echinococcus granulosus SHC transforming protein 3 0.0499 0.5337 0.5337
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0328 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Schistosoma mansoni hypothetical protein 0.0499 0.5337 0.5337
Loa Loa (eye worm) TK/ROR protein kinase 0.0328 0.2913 0.2914
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus granulosus retinal guanylyl cyclase 2 0.0328 0.2913 0.2913
Brugia malayi hypothetical protein 0.0499 0.5337 0.5339
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0328 0.2913 1
Brugia malayi SH2 domain containing protein 0.0499 0.5337 0.5339
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Brugia malayi SH2 domain containing protein 0.0828 0.9996 1
Brugia malayi SH2 domain containing protein 0.0499 0.5337 0.5339
Onchocerca volvulus 0.0828 0.9996 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus multilocularis growth factor receptor bound protein 2 0.0499 0.5337 0.5337
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0828 0.9996 0.9996
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0328 0.2913 0.2913
Schistosoma mansoni tensin 0.0499 0.5337 0.5337
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0328 0.2913 0.2913
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0328 0.2913 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0328 0.2913 0.5
Echinococcus granulosus SH2 domain containing protein 7 0.0499 0.5337 0.5337
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus granulosus tyrosine protein kinase pr2 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Schistosoma mansoni tyrosine kinase 0.0828 0.9996 0.9996
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis protein kinase 0.0328 0.2913 0.2913
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK protein kinase 0.0828 0.9996 1
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus granulosus retinal guanylyl cyclase 2 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Toxoplasma gondii STE kinase 0.0328 0.2913 0.5
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Schistosoma mansoni GTPase activating protein 0.0499 0.5337 0.5337
Echinococcus granulosus natriuretic peptide receptor 1 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0828 0.9996 0.9996
Echinococcus granulosus epidermal growth factor receptor 0.0328 0.2913 0.2913
Echinococcus granulosus receptor type guanylyl cyclase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/FER protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0328 0.2913 0.2913
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Trypanosoma brucei Flagellum attachment zone protein 20 0.0328 0.2913 0.5
Brugia malayi C-terminal src kinase protein 1 0.0328 0.2913 0.2914
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Plasmodium falciparum protein kinase, putative 0.0328 0.2913 0.5
Schistosoma mansoni protein kinase 0.0329 0.2917 0.2917
Trypanosoma brucei Pseudokinase, putative 0.0328 0.2913 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0328 0.2913 0.2914
Echinococcus granulosus protein tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis NCK adaptor protein 0.0499 0.5337 0.5337
Echinococcus multilocularis tyrosine kinase 0.0828 0.9996 0.9996
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/FER protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0499 0.5337 0.5337
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/FER protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Trichomonas vaginalis TKL family protein kinase 0.0328 0.2913 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis activin receptor type 0.0328 0.2913 0.2913
Giardia lamblia Kinase, NEK 0.0329 0.2917 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni growth factor receptor-bound protein 0.0499 0.5337 0.5337
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0328 0.2913 0.5
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Schistosoma mansoni suppressor of cytokine signaling 0.0499 0.5337 0.5337
Schistosoma mansoni protein kinase 0.0329 0.2917 0.2917
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Onchocerca volvulus 0.0328 0.2913 0.000000080628
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Brugia malayi RhoGAP domain containing protein 0.0499 0.5337 0.5339
Schistosoma mansoni tensin 0.0499 0.5337 0.5337
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0499 0.5337 0.5337
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0828 0.9996 0.9996
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus multilocularis N chimaerin 0.0499 0.5337 0.5337
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Giardia lamblia Protein 21.1 0.0328 0.2913 0.0001
Echinococcus multilocularis SH2 motif 0.0499 0.5337 0.5337
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0499 0.5337 0.5337
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.2913 0.2913
Entamoeba histolytica protein kinase, putative 0.0328 0.2913 0.000000080628
Brugia malayi ephrin receptor 1 precursor 0.0328 0.2913 0.2914
Plasmodium vivax protein kinase, putative 0.0328 0.2913 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0192 0.0977 0.0977
Echinococcus multilocularis integrin linked protein kinase 0.0328 0.2913 0.2913
Brugia malayi SH2 domain containing protein 0.0499 0.5337 0.5339
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0328 0.2913 0.2913
Echinococcus multilocularis tyrosine protein kinase csk 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) SH2 domain-containing protein 0.0499 0.5337 0.5339
Echinococcus multilocularis insulin receptor 0.0328 0.2913 0.2913
Echinococcus granulosus raf serine:threonine protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0499 0.5337 0.3423
Trypanosoma cruzi protein kinase, putative 0.0328 0.2913 0.5
Loa Loa (eye worm) TK/DDR protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0328 0.2913 0.2913
Echinococcus granulosus N chimaerin 0.0499 0.5337 0.5337
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Brugia malayi SRC-1 0.0828 0.9996 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0828 0.9996 0.9996
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0499 0.5337 0.5337
Brugia malayi Protein kinase domain containing protein 0.0828 0.9996 1
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.2913 0.2913
Schistosoma mansoni ephrin receptor 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni adapter molecule crk 0.0499 0.5337 0.5337
Schistosoma mansoni ephrin receptor 0.0328 0.2913 0.2913
Toxoplasma gondii protein kinase domain-containing protein 0.0328 0.2913 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0828 0.9996 0.9996
Brugia malayi Tyrosine-protein kinase PR2 0.0328 0.2913 0.2914
Echinococcus granulosus activin receptor type 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0328 0.2913 0.2913
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0499 0.5337 0.5337
Echinococcus granulosus tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Entamoeba histolytica protein kinase, putative 0.0499 0.5337 0.3423
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0828 0.9996 0.9996
Echinococcus granulosus insulin receptor 0.0328 0.2913 0.2913
Echinococcus multilocularis receptor type guanylyl cyclase 0.0328 0.2913 0.2913
Brugia malayi hypothetical protein 0.0328 0.2913 0.2914
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0499 0.5337 0.5337
Brugia malayi STAT protein, DNA binding domain containing protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/FAK protein kinase 0.0328 0.2913 0.2914
Leishmania major protein kinase, putative 0.0328 0.2913 0.5
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus multilocularis tensin 0.0499 0.5337 0.5337
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus granulosus fibroblast growth factor receptor 4 0.0328 0.2913 0.2913
Loa Loa (eye worm) SH2 domain-containing protein 0.0499 0.5337 0.5339
Brugia malayi Variant SH3 domain containing protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) TK/FER protein kinase 0.0328 0.2913 0.2914
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0328 0.2913 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Loa Loa (eye worm) STAT protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) RGC/RGC protein kinase 0.0328 0.2913 0.2914
Schistosoma mansoni growth factor receptor-bound protein 0.0499 0.5337 0.5337
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0499 0.5337 0.5339
Entamoeba histolytica SH2 domain containing protein 0.0499 0.5337 0.3423
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0828 0.9996 0.9996
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0499 0.5337 0.5337
Loa Loa (eye worm) TK/Met protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus ankyrin repeat protein 0.0192 0.0977 0.0977
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine protein kinase Lyn 0.0828 0.9996 0.9996
Echinococcus granulosus protein kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0828 0.9996 0.9996
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni tensin-related 0.0499 0.5337 0.5337
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0328 0.2913 0.2914
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0499 0.5337 0.5337
Echinococcus granulosus signal transduction protein lnk realted 0.0499 0.5337 0.5337
Echinococcus granulosus retinal guanylyl cyclase 2 0.0328 0.2913 0.2913
Brugia malayi Guanylyl cyclase protein 23 0.0328 0.2913 0.2914
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/ACK protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/FER protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis SH2 domain containing protein 7 0.0499 0.5337 0.5337
Onchocerca volvulus 0.0499 0.5337 0.3423
Echinococcus granulosus tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Brugia malayi SH2 domain containing protein 0.0499 0.5337 0.5339
Echinococcus multilocularis raf serine:threonine protein kinase 0.0328 0.2913 0.2913
Plasmodium falciparum tyrosine kinase-like protein 0.0328 0.2913 0.5
Trichomonas vaginalis TKL family protein kinase 0.0328 0.2913 1
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis epidermal growth factor receptor 0.0328 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0328 0.2913 0.2913
Loa Loa (eye worm) RGC/RGC protein kinase 0.0328 0.2913 0.2914
Brugia malayi hypothetical protein 0.0828 0.9996 1
Echinococcus granulosus integrin linked protein kinase 0.0328 0.2913 0.2913
Brugia malayi Sex muscle abnormal protein 5 0.0499 0.5337 0.5339
Echinococcus multilocularis tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine protein kinase ABL1 0.0828 0.9996 0.9996
Schistosoma mansoni tyrosine kinase 0.0828 0.9996 0.9996
Brugia malayi SH2 domain containing protein 0.0828 0.9996 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0499 0.5337 0.5337
Onchocerca volvulus 0.0828 0.9996 1
Echinococcus granulosus hypothetical protein 0.0499 0.5337 0.5337
Echinococcus multilocularis protein kinase 0.0328 0.2913 0.2913
Echinococcus granulosus tyrosine protein kinase Srms 0.0828 0.9996 0.9996
Plasmodium falciparum protein kinase, putative 0.0328 0.2913 0.5
Onchocerca volvulus 0.0828 0.9996 1
Schistosoma mansoni shc transforming protein 0.0499 0.5337 0.5337
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0828 0.9996 1
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0499 0.5337 0.5339
Brugia malayi Variant SH3 domain containing protein 0.0499 0.5337 0.5339
Echinococcus granulosus tyrosine protein kinase csk 0.0328 0.2913 0.2913
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0499 0.5337 0.5337
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Trichomonas vaginalis TKL family protein kinase 0.0328 0.2913 1
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0828 0.9996 1
Echinococcus multilocularis SH2 motif 0.0499 0.5337 0.5337
Echinococcus multilocularis heat shock protein 70 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Onchocerca volvulus 0.0499 0.5337 0.3423
Echinococcus multilocularis SH2 motif 0.0499 0.5337 0.5337
Echinococcus multilocularis tyrosine protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Brugia malayi Variant SH3 domain containing protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) TK/FER protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0828 0.9996 0.9996
Echinococcus granulosus tyrosine kinase 0.0828 0.9996 0.9996
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0828 0.9996 0.9996
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0499 0.5337 0.3423
Echinococcus granulosus tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0828 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0196 0.1032 0.1032
Loa Loa (eye worm) SH2 domain-containing protein 0.0499 0.5337 0.5339
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0828 0.9996 0.9996
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) RGC/RGC protein kinase 0.0328 0.2913 0.2914
Brugia malayi Tensin 0.0499 0.5337 0.5339
Echinococcus granulosus tyrosine kinase 0.0828 0.9996 0.9996
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0499 0.5337 0.5337
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Loa Loa (eye worm) TK protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0499 0.5337 0.5339
Echinococcus granulosus kinase suppressor of Ras 1 0.0328 0.2913 0.2913
Onchocerca volvulus 0.0828 0.9996 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0828 0.9996 0.9996
Loa Loa (eye worm) TK/FER protein kinase 0.0328 0.2913 0.2914
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni hypothetical protein 0.0499 0.5337 0.5337
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0499 0.5337 0.5337
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0828 0.9996 0.9996
Brugia malayi cytokine inducible SH2-containing protein 5 0.0499 0.5337 0.5339
Loa Loa (eye worm) TK/ALK protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus granulosus tyrosine protein kinase Src42A 0.0499 0.5337 0.5337
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0328 0.2913 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Leishmania major hypothetical protein, conserved 0.0328 0.2913 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0499 0.5337 0.3423
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0328 0.2913 0.2914
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0828 0.9996 0.9996
Loa Loa (eye worm) TK/EGFR protein kinase 0.0328 0.2913 0.2914
Schistosoma mansoni signal transduction protein lnk-related 0.0499 0.5337 0.5337
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Brugia malayi Variant SH3 domain containing protein 0.0499 0.5337 0.5339
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Echinococcus multilocularis tyrosine protein kinase Srms 0.0828 0.9996 0.9996
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) RGC/RGC protein kinase 0.0328 0.2913 0.2914
Brugia malayi SH2 domain containing protein 0.0499 0.5337 0.5339
Loa Loa (eye worm) TK/INSR protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis c src tyrosine kinase 0.0828 0.9996 0.9996
Loa Loa (eye worm) protein kinase domain-containing protein 0.0328 0.2913 0.2914
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0828 0.9996 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0499 0.5337 0.5337
Echinococcus granulosus tensin 0.0499 0.5337 0.5337
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0328 0.2913 0.2913
Echinococcus multilocularis epidermal growth factor receptor 0.0328 0.2913 0.2913
Entamoeba histolytica protein kinase, putative 0.0328 0.2913 0.000000080628
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) SRC-1 0.0828 0.9996 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0328 0.2913 0.2914
Echinococcus multilocularis transient receptor potential cation channel 0.0196 0.1036 0.1036
Loa Loa (eye worm) TK/CSK protein kinase 0.0328 0.2913 0.2914
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0828 0.9996 0.9996
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0328 0.2913 0.2913
Echinococcus granulosus SH2 domain containing adapter protein F 0.0499 0.5337 0.5337
Echinococcus granulosus activated cdc42 kinase 1 0.0328 0.2913 0.2913
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0328 0.2913 0.2913
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0499 0.5337 0.5337
Brugia malayi SH2 domain containing protein 0.0499 0.5337 0.5339
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0328 0.2913 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0828 0.9996 0.9996
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0499 0.5337 0.5337
Brugia malayi hypothetical protein 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0828 0.9996 1
Schistosoma mansoni tensin 0.0499 0.5337 0.5337
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0328 0.2913 0.5
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0499 0.5337 0.5337
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0328 0.2913 0.2914
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0328 0.2913 0.2913
Onchocerca volvulus 0.0828 0.9996 1
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Echinococcus granulosus tyrosine protein kinase csk 0.0328 0.2913 0.2913
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0328 0.2913 0.2913
Schistosoma mansoni tyrosine protein kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0499 0.5337 0.5337
Onchocerca volvulus 0.0499 0.5337 0.3423
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0828 0.9996 0.9996
Brugia malayi bone morphogenetic protein type 1 receptor 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Brugia malayi integrin-linked kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis transfer RNA-Thr 0.0328 0.2913 0.2913
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Echinococcus multilocularis 0.0499 0.5337 0.5337
Echinococcus multilocularis tyrosine protein kinase Abl 0.0828 0.9996 0.9996
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0828 0.9996 0.9996
Loa Loa (eye worm) hypothetical protein 0.0499 0.5337 0.5339
Echinococcus multilocularis tyrosine protein kinase csk 0.0328 0.2913 0.2913
Echinococcus multilocularis SHC transforming protein 3 0.0499 0.5337 0.5337
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0499 0.5337 0.5339
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Brugia malayi Protein kinase domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni protein kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0328 0.2913 0.2914
Echinococcus multilocularis FL cytokine receptor 0.0328 0.2913 0.2913
Echinococcus granulosus expressed conserved protein 0.0499 0.5337 0.5337
Schistosoma mansoni suppressor of cytokine signaling 0.0499 0.5337 0.5337
Onchocerca volvulus 0.0828 0.9996 1
Brugia malayi protein-tyrosine kinase 0.0828 0.9996 1
Entamoeba histolytica ankyrin repeat protein 0.0328 0.2913 0.000000080628
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0499 0.5337 0.5337
Echinococcus granulosus growth factor receptor bound protein 2 0.0499 0.5337 0.5337
Echinococcus multilocularis tyrosine protein kinase csk 0.0328 0.2913 0.2913
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0328 0.2913 0.2914
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0828 0.9996 0.9996
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.2913 0.2914
Trypanosoma cruzi protein kinase, putative 0.0328 0.2913 0.5
Schistosoma mansoni tyrosine kinase 0.0328 0.2913 0.2913
Loa Loa (eye worm) TK/FER protein kinase 0.0828 0.9996 1

Activities

Activity type Activity value Assay description Source Reference
Efficacy (binding) < 10 % Agonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as increase in allyl isothiocyanate-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis relative to control ChEMBL. 23206861
Efficacy (binding) < 10 % Agonist activity at human TRPV1 overexpressed in HEK293 cells assessed as increase in ionomycin-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis relative to control ChEMBL. 23206861
IC50 (binding) > 10 uM Inhibition of FAAH in rat brain homogenates using [14C]anandamide as substrate assessed as formation of [14C]ethanolamine after 30 mins by scintillation counting analysis ChEMBL. 23206861
IC50 (binding) = 10.6 uM Antagonist activity at human TRPV1 overexpressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level incubated for 5 mins prior to capsaicin addition by Fluo-4 based spectrofluorimetric analysis ChEMBL. 23206861
IC50 (binding) = 11.67 uM Antagonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ level incubated for 5 mins prior to allyl isothiocyanate addition by Fluo-4 based spectrofluorimetric analysis ChEMBL. 23206861

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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